% IMPORTANT: The following is UTF-8 encoded.  This means that in the presence
% of non-ASCII characters, it will not work with BibTeX 0.99 or older.
% Instead, you should use an up-to-date BibTeX implementation like “bibtex8” or
% “biber”.

@ARTICLE{Khan:169177,
      author       = {Khan, Mudassar N and Cherukuri, Pitchaiah and Negro,
                      Francesco and Rajput, Ashish and Fabrowski, Piotr and
                      Bansal, Vikas and Lancelin, Camille and Lee, Tsung-I and
                      Bian, Yehan and Mayer, William P and Akay, Turgay and
                      Müller, Daniel and Bonn, Stefan and Farina, Dario and
                      Marquardt, Till},
      title        = {{ERR}2 and {ERR}3 promote the development of gamma motor
                      neuron functional properties required for proprioceptive
                      movement control.},
      journal      = {PLoS biology},
      volume       = {20},
      number       = {12},
      issn         = {1544-9173},
      address      = {Lawrence, KS},
      publisher    = {PLoS},
      reportid     = {DZNE-2023-00056},
      pages        = {e3001923},
      year         = {2022},
      abstract     = {The ability of terrestrial vertebrates to effectively move
                      on land is integrally linked to the diversification of motor
                      neurons into types that generate muscle force (alpha motor
                      neurons) and types that modulate muscle proprioception, a
                      task that in mammals is chiefly mediated by gamma motor
                      neurons. The diversification of motor neurons into alpha and
                      gamma types and their respective contributions to movement
                      control have been firmly established in the past 7 decades,
                      while recent studies identified gene expression signatures
                      linked to both motor neuron types. However, the mechanisms
                      that promote the specification of gamma motor neurons and/or
                      their unique properties remained unaddressed. Here, we found
                      that upon selective loss of the orphan nuclear receptors
                      ERR2 and ERR3 (also known as ERRβ, ERRγ or NR3B2, NR3B3,
                      respectively) in motor neurons in mice, morphologically
                      distinguishable gamma motor neurons are generated but do not
                      acquire characteristic functional properties necessary for
                      regulating muscle proprioception, thus disrupting gait and
                      precision movements. Complementary gain-of-function
                      experiments in chick suggest that ERR2 and ERR3 could
                      operate via transcriptional activation of neural activity
                      modulators to promote a gamma motor neuron biophysical
                      signature of low firing thresholds and high firing rates.
                      Our work identifies a mechanism specifying gamma motor
                      neuron functional properties essential for the regulation of
                      proprioceptive movement control.},
      keywords     = {Animals / Mice / Motor Neurons, Gamma: physiology /
                      Movement / Muscles / Proprioception / Receptors, Estrogen:
                      metabolism / Esrrb protein, mouse (NLM Chemicals) /
                      Receptors, Estrogen (NLM Chemicals) / Esrrg protein, mouse
                      (NLM Chemicals)},
      cin          = {AG Heutink 1},
      ddc          = {610},
      cid          = {I:(DE-2719)1210002},
      pnm          = {354 - Disease Prevention and Healthy Aging (POF4-354)},
      pid          = {G:(DE-HGF)POF4-354},
      typ          = {PUB:(DE-HGF)16},
      pmc          = {pmc:PMC9815657},
      pubmed       = {pmid:36542664},
      doi          = {10.1371/journal.pbio.3001923},
      url          = {https://pub.dzne.de/record/169177},
}