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001     169187
005     20240112171842.0
024 7 _ |a 10.1002/chem.202203493
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037 _ _ |a DZNE-2023-00066
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100 1 _ |a Abyzov, Anton
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245 _ _ |a Fast Motions Dominate Dynamics of Intrinsically Disordered Tau Protein at High Temperatures.
260 _ _ |a Weinheim
|c 2023
|b Wiley-VCH
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520 _ _ |a Reorientational dynamics of intrinsically disordered proteins (IDPs) contain multiple motions often clustered around three motional modes: ultrafast librational motions of amide groups, fast local backbone conformational fluctuations and slow chain segmental motions. This dynamic picture is mainly based on 15 N NMR relaxation studies of IDPs at relatively low temperatures where the amide-water proton exchange rates are sufficiently small. Less is known, however, about the dynamics of IDPs at more physiological temperatures. Here, we investigate protein dynamics in a 441-residue long IDP, tau protein, in the temperature range from 0-25 °C, using 15 N NMR relaxation rates and spectral density analysis. While at these temperatures relaxation rates are still better described in terms of amide group librational motions, local backbone dynamics and chain segmental motions, the temperature-dependent trend of spectral densities suggests that the timescales of fast backbone conformational fluctuations and slower chain segmental motions might become inseparable at higher temperatures. Our data demonstrate the remarkable dynamic plasticity of this prototypical IDP and highlight the need for dynamic studies of IDPs at multiple temperatures.
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650 _ 2 |a Temperature
|2 MeSH
650 _ 2 |a Protein Conformation
|2 MeSH
650 _ 2 |a tau Proteins
|2 MeSH
650 _ 2 |a Magnetic Resonance Spectroscopy
|2 MeSH
650 _ 2 |a Intrinsically Disordered Proteins: chemistry
|2 MeSH
650 _ 2 |a Amides
|2 MeSH
650 _ 7 |a tau Proteins
|2 NLM Chemicals
650 _ 7 |a Intrinsically disordered protein
|2 Other
650 _ 7 |a NMR relaxation
|2 Other
650 _ 7 |a protein dynamics
|2 Other
650 _ 7 |a spectral density analysis
|2 Other
650 _ 7 |a tau protein
|2 Other
650 _ 7 |a Intrinsically Disordered Proteins
|2 NLM Chemicals
650 _ 7 |a Amides
|2 NLM Chemicals
700 1 _ |a Mandelkow, Eckhard
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700 1 _ |a Zweckstetter, Markus
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700 1 _ |a Rezaei-Ghaleh, Nasrollah
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773 _ _ |a 10.1002/chem.202203493
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|t Chemistry - a European journal
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|y 2023
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856 4 _ |u https://pub.dzne.de/record/169187/files/DZNE-2023-00066.pdf
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