TY  - JOUR
AU  - Felgel-Farnholz, Viktoria
AU  - Hlusicka, Elizabeth Barroeta
AU  - Edemann-Callesen, Henriette
AU  - Garthe, Alexander
AU  - Winter, Christine
AU  - Hadar, Ravit
TI  - Adolescent raloxifene treatment in females prevents cognitive deficits in a neurodevelopmental rodent model of schizophrenia.
JO  - Behavioural brain research
VL  - 441
SN  - 0166-4328
CY  - Amsterdam
PB  - Elsevier
M1  - DZNE-2023-00070
SP  - 114276
PY  - 2023
AB  - The existence of sex differences in schizophrenia is a well documented phenomenon which led to the hypothesis that female sex hormones are neuroprotective and hence responsible for the more favorable disease characteristics seen in women. The current study sought to investigate the effects of estrogen-like agents administered during early adolescence on behavioral outcomes in adulthood using the neurodevelopmental maternal immune activation (MIA) rodent model of schizophrenia. Female MIA offspring were administered during the asymptomatic period of adolescence with either 17β-estradiol, raloxifene or saline and were tested in late adolescence and adulthood for schizophrenia-related behavioral performance. We report here that whereas adult female MIA offspring exhibited cognitive deficits in the form of retarded spatial learning, the administration of raloxifene during adolescence was sufficient in preventing these deficits and resulted in intact performance in the MIA group.
KW  - Animals
KW  - Humans
KW  - Female
KW  - Male
KW  - Raloxifene Hydrochloride: pharmacology
KW  - Schizophrenia: complications
KW  - Schizophrenia: drug therapy
KW  - Rodentia
KW  - Poly I-C: pharmacology
KW  - Behavior, Animal: physiology
KW  - Disease Models, Animal
KW  - Prenatal Exposure Delayed Effects
KW  - Cognition
KW  - Raloxifene Hydrochloride (NLM Chemicals)
KW  - Morris Water Maze (MWM) (Other)
KW  - Poly I:C (Other)
KW  - Preventive hormonal treatment (Other)
KW  - Raloxifene (Other)
KW  - estradiol (Other)
KW  - schizophrenia (Other)
KW  - Poly I-C (NLM Chemicals)
LB  - PUB:(DE-HGF)16
C6  - pmid:36574844
DO  - DOI:10.1016/j.bbr.2022.114276
UR  - https://pub.dzne.de/record/169191
ER  -