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@ARTICLE{FelgelFarnholz:169191,
      author       = {Felgel-Farnholz, Viktoria and Hlusicka, Elizabeth Barroeta
                      and Edemann-Callesen, Henriette and Garthe, Alexander and
                      Winter, Christine and Hadar, Ravit},
      title        = {{A}dolescent raloxifene treatment in females prevents
                      cognitive deficits in a neurodevelopmental rodent model of
                      schizophrenia.},
      journal      = {Behavioural brain research},
      volume       = {441},
      issn         = {0166-4328},
      address      = {Amsterdam},
      publisher    = {Elsevier},
      reportid     = {DZNE-2023-00070},
      pages        = {114276},
      year         = {2023},
      abstract     = {The existence of sex differences in schizophrenia is a well
                      documented phenomenon which led to the hypothesis that
                      female sex hormones are neuroprotective and hence
                      responsible for the more favorable disease characteristics
                      seen in women. The current study sought to investigate the
                      effects of estrogen-like agents administered during early
                      adolescence on behavioral outcomes in adulthood using the
                      neurodevelopmental maternal immune activation (MIA) rodent
                      model of schizophrenia. Female MIA offspring were
                      administered during the asymptomatic period of adolescence
                      with either 17β-estradiol, raloxifene or saline and were
                      tested in late adolescence and adulthood for
                      schizophrenia-related behavioral performance. We report here
                      that whereas adult female MIA offspring exhibited cognitive
                      deficits in the form of retarded spatial learning, the
                      administration of raloxifene during adolescence was
                      sufficient in preventing these deficits and resulted in
                      intact performance in the MIA group.},
      keywords     = {Animals / Humans / Female / Male / Raloxifene
                      Hydrochloride: pharmacology / Schizophrenia: complications /
                      Schizophrenia: drug therapy / Rodentia / Poly I-C:
                      pharmacology / Behavior, Animal: physiology / Disease
                      Models, Animal / Prenatal Exposure Delayed Effects /
                      Cognition / Raloxifene Hydrochloride (NLM Chemicals) /
                      Morris Water Maze (MWM) (Other) / Poly I:C (Other) /
                      Preventive hormonal treatment (Other) / Raloxifene (Other) /
                      estradiol (Other) / schizophrenia (Other) / Poly I-C (NLM
                      Chemicals)},
      cin          = {AG Garthe},
      ddc          = {610},
      cid          = {I:(DE-2719)1740001},
      pnm          = {352 - Disease Mechanisms (POF4-352)},
      pid          = {G:(DE-HGF)POF4-352},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:36574844},
      doi          = {10.1016/j.bbr.2022.114276},
      url          = {https://pub.dzne.de/record/169191},
}