000169274 001__ 169274 000169274 005__ 20240612102722.0 000169274 0247_ $$2pmc$$apmc:PMC9999291 000169274 0247_ $$2doi$$a10.1016/j.neuron.2022.10.020 000169274 0247_ $$2pmid$$apmid:36327895 000169274 0247_ $$2ISSN$$a0896-6273 000169274 0247_ $$2ISSN$$a1097-4199 000169274 0247_ $$2altmetric$$aaltmetric:137964928 000169274 037__ $$aDZNE-2023-00112 000169274 041__ $$aEnglish 000169274 082__ $$a610 000169274 1001_ $$aPaolicelli, Rosa C$$b0 000169274 245__ $$aMicroglia states and nomenclature: A field at its crossroads. 000169274 260__ $$aNew York, NY$$bElsevier$$c2022 000169274 3367_ $$2DRIVER$$aarticle 000169274 3367_ $$2DataCite$$aOutput Types/Journal article 000169274 3367_ $$0PUB:(DE-HGF)16$$2PUB:(DE-HGF)$$aJournal Article$$bjournal$$mjournal$$s1718180826_28348 000169274 3367_ $$2BibTeX$$aARTICLE 000169274 3367_ $$2ORCID$$aJOURNAL_ARTICLE 000169274 3367_ $$00$$2EndNote$$aJournal Article 000169274 520__ $$aMicroglial research has advanced considerably in recent decades yet has been constrained by a rolling series of dichotomies such as 'resting versus activated' and 'M1 versus M2.' This dualistic classification of good or bad microglia is inconsistent with the wide repertoire of microglial states and functions in development, plasticity, aging, and diseases that were elucidated in recent years. New designations continuously arising in an attempt to describe the different microglial states, notably defined using transcriptomics and proteomics, may easily lead to a misleading, although unintentional, coupling of categories and functions. To address these issues, we assembled a group of multidisciplinary experts to discuss our current understanding of microglial states as a dynamic concept and the importance of addressing microglial function. Here, we provide a conceptual framework and recommendations on the use of microglial nomenclature for researchers, reviewers, and editors, which will serve as the foundations for a future white paper. 000169274 536__ $$0G:(DE-HGF)POF4-353$$a353 - Clinical and Health Care Research (POF4-353)$$cPOF4-353$$fPOF IV$$x0 000169274 536__ $$0G:(DE-HGF)POF4-352$$a352 - Disease Mechanisms (POF4-352)$$cPOF4-352$$fPOF IV$$x1 000169274 536__ $$0G:(DE-HGF)POF4-351$$a351 - Brain Function (POF4-351)$$cPOF4-351$$fPOF IV$$x2 000169274 588__ $$aDataset connected to CrossRef, PubMed, , Journals: pub.dzne.de 000169274 650_2 $$2MeSH$$aMicroglia 000169274 7001_ $$aSierra, Amanda$$b1 000169274 7001_ $$aStevens, Beth$$b2 000169274 7001_ $$aTremblay, Marie-Eve$$b3 000169274 7001_ $$aAguzzi, Adriano$$b4 000169274 7001_ $$aAjami, Bahareh$$b5 000169274 7001_ $$aAmit, Ido$$b6 000169274 7001_ $$aAudinat, Etienne$$b7 000169274 7001_ $$aBechmann, Ingo$$b8 000169274 7001_ $$aBennett, Mariko$$b9 000169274 7001_ $$aBennett, Frederick$$b10 000169274 7001_ $$aBessis, Alain$$b11 000169274 7001_ $$aBiber, Knut$$b12 000169274 7001_ $$aBilbo, Staci$$b13 000169274 7001_ $$aBlurton-Jones, Mathew$$b14 000169274 7001_ $$aBoddeke, Erik$$b15 000169274 7001_ $$aBrites, Dora$$b16 000169274 7001_ $$aBrône, Bert$$b17 000169274 7001_ $$aBrown, Guy C$$b18 000169274 7001_ $$aButovsky, Oleg$$b19 000169274 7001_ $$aCarson, Monica J$$b20 000169274 7001_ $$aCastellano, Bernardo$$b21 000169274 7001_ $$aColonna, Marco$$b22 000169274 7001_ $$aCowley, Sally A$$b23 000169274 7001_ $$aCunningham, Colm$$b24 000169274 7001_ $$aDavalos, Dimitrios$$b25 000169274 7001_ $$aDe Jager, Philip L$$b26 000169274 7001_ $$ade Strooper, Bart$$b27 000169274 7001_ $$aDenes, Adam$$b28 000169274 7001_ $$aEggen, Bart J L$$b29 000169274 7001_ $$aEyo, Ukpong$$b30 000169274 7001_ $$aGalea, Elena$$b31 000169274 7001_ $$aGarel, Sonia$$b32 000169274 7001_ $$aGinhoux, Florent$$b33 000169274 7001_ $$aGlass, Christopher K$$b34 000169274 7001_ $$0P:(DE-2719)9002754$$aGökce, Ozgun$$b35$$udzne 000169274 7001_ $$aGomez-Nicola, Diego$$b36 000169274 7001_ $$aGonzález, Berta$$b37 000169274 7001_ $$aGordon, Siamon$$b38 000169274 7001_ $$aGraeber, Manuel B$$b39 000169274 7001_ $$aGreenhalgh, Andrew D$$b40 000169274 7001_ $$aGressens, Pierre$$b41 000169274 7001_ $$aGreter, Melanie$$b42 000169274 7001_ $$aGutmann, David H$$b43 000169274 7001_ $$0P:(DE-2719)2202037$$aHaass, Christian$$b44 000169274 7001_ $$0P:(DE-2719)2000008$$aHeneka, Michael$$b45 000169274 7001_ $$0P:(DE-2719)2812386$$aHeppner, Frank L$$b46 000169274 7001_ $$aHong, Soyon$$b47 000169274 7001_ $$aHume, David A$$b48 000169274 7001_ $$aJung, Steffen$$b49 000169274 7001_ $$aKettenmann, Helmut$$b50 000169274 7001_ $$aKipnis, Jonathan$$b51 000169274 7001_ $$aKoyama, Ryuta$$b52 000169274 7001_ $$aLemke, Greg$$b53 000169274 7001_ $$aLynch, Marina$$b54 000169274 7001_ $$aMajewska, Ania$$b55 000169274 7001_ $$aMalcangio, Marzia$$b56 000169274 7001_ $$aMalm, Tarja$$b57 000169274 7001_ $$aMancuso, Renzo$$b58 000169274 7001_ $$aMasuda, Takahiro$$b59 000169274 7001_ $$aMatteoli, Michela$$b60 000169274 7001_ $$aMcColl, Barry W$$b61 000169274 7001_ $$aMiron, Veronique E$$b62 000169274 7001_ $$aMolofsky, Anna Victoria$$b63 000169274 7001_ $$aMonje, Michelle$$b64 000169274 7001_ $$aMracsko, Eva$$b65 000169274 7001_ $$aNadjar, Agnes$$b66 000169274 7001_ $$0P:(DE-2719)2811021$$aNeher, Jonas J$$b67 000169274 7001_ $$aNeniskyte, Urte$$b68 000169274 7001_ $$aNeumann, Harald$$b69 000169274 7001_ $$aNoda, Mami$$b70 000169274 7001_ $$aPeng, Bo$$b71 000169274 7001_ $$aPeri, Francesca$$b72 000169274 7001_ $$aPerry, V Hugh$$b73 000169274 7001_ $$aPopovich, Phillip G$$b74 000169274 7001_ $$aPridans, Clare$$b75 000169274 7001_ $$0P:(DE-2719)2811122$$aPriller, Josef$$b76 000169274 7001_ $$aPrinz, Marco$$b77 000169274 7001_ $$aRagozzino, Davide$$b78 000169274 7001_ $$aRansohoff, Richard M$$b79 000169274 7001_ $$aSalter, Michael W$$b80 000169274 7001_ $$aSchaefer, Anne$$b81 000169274 7001_ $$aSchafer, Dorothy P$$b82 000169274 7001_ $$aSchwartz, Michal$$b83 000169274 7001_ $$0P:(DE-2719)2811642$$aSimons, Mikael$$b84 000169274 7001_ $$aSmith, Cody J$$b85 000169274 7001_ $$aStreit, Wolfgang J$$b86 000169274 7001_ $$aTay, Tuan Leng$$b87 000169274 7001_ $$aTsai, Li-Huei$$b88 000169274 7001_ $$aVerkhratsky, Alexei$$b89 000169274 7001_ $$avon Bernhardi, Rommy$$b90 000169274 7001_ $$aWake, Hiroaki$$b91 000169274 7001_ $$aWittamer, Valérie$$b92 000169274 7001_ $$0P:(DE-HGF)0$$aWolf, Susanne A$$b93 000169274 7001_ $$aWu, Long-Jun$$b94 000169274 7001_ $$aWyss-Coray, Tony$$b95 000169274 773__ $$0PERI:(DE-600)2001944-0$$a10.1016/j.neuron.2022.10.020$$gVol. 110, no. 21, p. 3458 - 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