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@ARTICLE{Paolicelli:169274,
author = {Paolicelli, Rosa C and Sierra, Amanda and Stevens, Beth and
Tremblay, Marie-Eve and Aguzzi, Adriano and Ajami, Bahareh
and Amit, Ido and Audinat, Etienne and Bechmann, Ingo and
Bennett, Mariko and Bennett, Frederick and Bessis, Alain and
Biber, Knut and Bilbo, Staci and Blurton-Jones, Mathew and
Boddeke, Erik and Brites, Dora and Brône, Bert and Brown,
Guy C and Butovsky, Oleg and Carson, Monica J and
Castellano, Bernardo and Colonna, Marco and Cowley, Sally A
and Cunningham, Colm and Davalos, Dimitrios and De Jager,
Philip L and de Strooper, Bart and Denes, Adam and Eggen,
Bart J L and Eyo, Ukpong and Galea, Elena and Garel, Sonia
and Ginhoux, Florent and Glass, Christopher K and Gökce,
Ozgun and Gomez-Nicola, Diego and González, Berta and
Gordon, Siamon and Graeber, Manuel B and Greenhalgh, Andrew
D and Gressens, Pierre and Greter, Melanie and Gutmann,
David H and Haass, Christian and Heneka, Michael and
Heppner, Frank L and Hong, Soyon and Hume, David A and Jung,
Steffen and Kettenmann, Helmut and Kipnis, Jonathan and
Koyama, Ryuta and Lemke, Greg and Lynch, Marina and
Majewska, Ania and Malcangio, Marzia and Malm, Tarja and
Mancuso, Renzo and Masuda, Takahiro and Matteoli, Michela
and McColl, Barry W and Miron, Veronique E and Molofsky,
Anna Victoria and Monje, Michelle and Mracsko, Eva and
Nadjar, Agnes and Neher, Jonas J and Neniskyte, Urte and
Neumann, Harald and Noda, Mami and Peng, Bo and Peri,
Francesca and Perry, V Hugh and Popovich, Phillip G and
Pridans, Clare and Priller, Josef and Prinz, Marco and
Ragozzino, Davide and Ransohoff, Richard M and Salter,
Michael W and Schaefer, Anne and Schafer, Dorothy P and
Schwartz, Michal and Simons, Mikael and Smith, Cody J and
Streit, Wolfgang J and Tay, Tuan Leng and Tsai, Li-Huei and
Verkhratsky, Alexei and von Bernhardi, Rommy and Wake,
Hiroaki and Wittamer, Valérie and Wolf, Susanne A and Wu,
Long-Jun and Wyss-Coray, Tony},
title = {{M}icroglia states and nomenclature: {A} field at its
crossroads.},
journal = {Neuron},
volume = {110},
number = {21},
issn = {0896-6273},
address = {New York, NY},
publisher = {Elsevier},
reportid = {DZNE-2023-00112},
pages = {3458 - 3483},
year = {2022},
abstract = {Microglial research has advanced considerably in recent
decades yet has been constrained by a rolling series of
dichotomies such as 'resting versus activated' and 'M1
versus M2.' This dualistic classification of good or bad
microglia is inconsistent with the wide repertoire of
microglial states and functions in development, plasticity,
aging, and diseases that were elucidated in recent years.
New designations continuously arising in an attempt to
describe the different microglial states, notably defined
using transcriptomics and proteomics, may easily lead to a
misleading, although unintentional, coupling of categories
and functions. To address these issues, we assembled a group
of multidisciplinary experts to discuss our current
understanding of microglial states as a dynamic concept and
the importance of addressing microglial function. Here, we
provide a conceptual framework and recommendations on the
use of microglial nomenclature for researchers, reviewers,
and editors, which will serve as the foundations for a
future white paper.},
keywords = {Microglia},
cin = {AG Priller / AG Neher / AG Simons / AG Haass},
ddc = {610},
cid = {I:(DE-2719)5000007 / I:(DE-2719)1210012 /
I:(DE-2719)1110008 / I:(DE-2719)1110007},
pnm = {353 - Clinical and Health Care Research (POF4-353) / 352 -
Disease Mechanisms (POF4-352) / 351 - Brain Function
(POF4-351)},
pid = {G:(DE-HGF)POF4-353 / G:(DE-HGF)POF4-352 /
G:(DE-HGF)POF4-351},
typ = {PUB:(DE-HGF)16},
pmc = {pmc:PMC9999291},
pubmed = {pmid:36327895},
doi = {10.1016/j.neuron.2022.10.020},
url = {https://pub.dzne.de/record/169274},
}