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000169366 0247_ $$2doi$$a10.1002/hipo.23494
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000169366 037__ $$aDZNE-2023-00141
000169366 041__ $$aEnglish
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000169366 1001_ $$0P:(DE-2719)2810548$$aZocher, Sara$$b0$$eFirst author$$udzne
000169366 245__ $$aEpigenetic aging in adult neurogenesis.
000169366 260__ $$aNew York, NY [u.a.]$$bWiley$$c2023
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000169366 500__ $$aFunding information: Deutsche Forschungsgemeinschaft, Grant/Award Numbers: TO1347/4-1, TO1347/3-1; H2020 European Research Council, Grant/Award Numbers: EAGER, 804468
000169366 520__ $$aNeural stem cells (NSCs) in the hippocampus generate new neurons throughout life, which functionally contribute to cognitive flexibility and mood regulation. Yet adult hippocampal neurogenesis substantially declines with age and age-related impairments in NSC activity underlie this reduction. Particularly, increased NSC quiescence and consequently reduced NSC proliferation are considered to be major drivers of the low neurogenesis levels in the aged brain. Epigenetic regulators control the gene expression programs underlying NSC quiescence, proliferation and differentiation and are hence critical to the regulation of adult neurogenesis. Epigenetic alterations have also emerged as central hallmarks of aging, and recent studies suggest the deterioration of the NSC-specific epigenetic landscape as a driver of the age-dependent decline in adult neurogenesis. In this review, we summarize the recently accumulating evidence for a role of epigenetic dysregulation in NSC aging and propose perspectives for future research directions.
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000169366 650_7 $$2Other$$aDNA methylation
000169366 650_7 $$2Other$$aLamin B1
000169366 650_7 $$2Other$$aaging
000169366 650_7 $$2Other$$achromatin
000169366 650_7 $$2Other$$aepigenetic
000169366 650_7 $$2Other$$ahippocampus
000169366 650_7 $$2Other$$ahistone
000169366 650_7 $$2Other$$aneural stem cells
000169366 650_7 $$2Other$$aneurogenesis
000169366 650_2 $$2MeSH$$aNeurogenesis: physiology
000169366 650_2 $$2MeSH$$aCell Differentiation: genetics
000169366 650_2 $$2MeSH$$aNeurons: metabolism
000169366 650_2 $$2MeSH$$aHippocampus: physiology
000169366 650_2 $$2MeSH$$aEpigenesis, Genetic
000169366 7001_ $$0P:(DE-2719)2814117$$aToda, Tomohisa$$b1$$eLast author$$udzne
000169366 770__ $$aAdult Neurogenesis in the Hippocampus
000169366 773__ $$0PERI:(DE-600)1498049-6$$a10.1002/hipo.23494$$gp. hipo.23494$$n4$$p347-359$$tHippocampus$$v33$$x1050-9631$$y2023
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