TY  - JOUR
AU  - Zocher, Sara
AU  - Toda, Tomohisa
TI  - Epigenetic aging in adult neurogenesis.
JO  - Hippocampus
VL  - 33
IS  - 4
SN  - 1050-9631
CY  - New York, NY [u.a.]
PB  - Wiley
M1  - DZNE-2023-00141
SP  - 347-359
PY  - 2023
N1  - Funding information: Deutsche Forschungsgemeinschaft, Grant/Award Numbers: TO1347/4-1, TO1347/3-1; H2020 European Research Council, Grant/Award Numbers: EAGER, 804468
AB  - Neural stem cells (NSCs) in the hippocampus generate new neurons throughout life, which functionally contribute to cognitive flexibility and mood regulation. Yet adult hippocampal neurogenesis substantially declines with age and age-related impairments in NSC activity underlie this reduction. Particularly, increased NSC quiescence and consequently reduced NSC proliferation are considered to be major drivers of the low neurogenesis levels in the aged brain. Epigenetic regulators control the gene expression programs underlying NSC quiescence, proliferation and differentiation and are hence critical to the regulation of adult neurogenesis. Epigenetic alterations have also emerged as central hallmarks of aging, and recent studies suggest the deterioration of the NSC-specific epigenetic landscape as a driver of the age-dependent decline in adult neurogenesis. In this review, we summarize the recently accumulating evidence for a role of epigenetic dysregulation in NSC aging and propose perspectives for future research directions.
KW  - Neurogenesis: physiology
KW  - Cell Differentiation: genetics
KW  - Neurons: metabolism
KW  - Hippocampus: physiology
KW  - Epigenesis, Genetic
KW  - DNA methylation (Other)
KW  - Lamin B1 (Other)
KW  - aging (Other)
KW  - chromatin (Other)
KW  - epigenetic (Other)
KW  - hippocampus (Other)
KW  - histone (Other)
KW  - neural stem cells (Other)
KW  - neurogenesis (Other)
LB  - PUB:(DE-HGF)16
C6  - pmid:36624660
DO  - DOI:10.1002/hipo.23494
UR  - https://pub.dzne.de/record/169366
ER  -