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@ARTICLE{Zocher:169366,
      author       = {Zocher, Sara and Toda, Tomohisa},
      title        = {{E}pigenetic aging in adult neurogenesis.},
      journal      = {Hippocampus},
      volume       = {33},
      number       = {4},
      issn         = {1050-9631},
      address      = {New York, NY [u.a.]},
      publisher    = {Wiley},
      reportid     = {DZNE-2023-00141},
      pages        = {347-359},
      year         = {2023},
      note         = {Funding information: Deutsche Forschungsgemeinschaft,
                      Grant/Award Numbers: TO1347/4-1, TO1347/3-1; H2020 European
                      Research Council, Grant/Award Numbers: EAGER, 804468},
      abstract     = {Neural stem cells (NSCs) in the hippocampus generate new
                      neurons throughout life, which functionally contribute to
                      cognitive flexibility and mood regulation. Yet adult
                      hippocampal neurogenesis substantially declines with age and
                      age-related impairments in NSC activity underlie this
                      reduction. Particularly, increased NSC quiescence and
                      consequently reduced NSC proliferation are considered to be
                      major drivers of the low neurogenesis levels in the aged
                      brain. Epigenetic regulators control the gene expression
                      programs underlying NSC quiescence, proliferation and
                      differentiation and are hence critical to the regulation of
                      adult neurogenesis. Epigenetic alterations have also emerged
                      as central hallmarks of aging, and recent studies suggest
                      the deterioration of the NSC-specific epigenetic landscape
                      as a driver of the age-dependent decline in adult
                      neurogenesis. In this review, we summarize the recently
                      accumulating evidence for a role of epigenetic dysregulation
                      in NSC aging and propose perspectives for future research
                      directions.},
      subtyp        = {Review Article},
      keywords     = {Neurogenesis: physiology / Cell Differentiation: genetics /
                      Neurons: metabolism / Hippocampus: physiology / Epigenesis,
                      Genetic / DNA methylation (Other) / Lamin B1 (Other) / aging
                      (Other) / chromatin (Other) / epigenetic (Other) /
                      hippocampus (Other) / histone (Other) / neural stem cells
                      (Other) / neurogenesis (Other)},
      cin          = {AG Toda},
      ddc          = {610},
      cid          = {I:(DE-2719)1710014},
      pnm          = {352 - Disease Mechanisms (POF4-352)},
      pid          = {G:(DE-HGF)POF4-352},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:36624660},
      doi          = {10.1002/hipo.23494},
      url          = {https://pub.dzne.de/record/169366},
}