Home > Publications Database > Epigenetic aging in adult neurogenesis. > print

001     169366
005     20231120155332.0
024 7 _ |a 10.1002/hipo.23494
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037 _ _ |a DZNE-2023-00141
041 _ _ |a English
082 _ _ |a 610
100 1 _ |a Zocher, Sara
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245 _ _ |a Epigenetic aging in adult neurogenesis.
260 _ _ |a New York, NY [u.a.]
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500 _ _ |a Funding information: Deutsche Forschungsgemeinschaft, Grant/Award Numbers: TO1347/4-1, TO1347/3-1; H2020 European Research Council, Grant/Award Numbers: EAGER, 804468
520 _ _ |a Neural stem cells (NSCs) in the hippocampus generate new neurons throughout life, which functionally contribute to cognitive flexibility and mood regulation. Yet adult hippocampal neurogenesis substantially declines with age and age-related impairments in NSC activity underlie this reduction. Particularly, increased NSC quiescence and consequently reduced NSC proliferation are considered to be major drivers of the low neurogenesis levels in the aged brain. Epigenetic regulators control the gene expression programs underlying NSC quiescence, proliferation and differentiation and are hence critical to the regulation of adult neurogenesis. Epigenetic alterations have also emerged as central hallmarks of aging, and recent studies suggest the deterioration of the NSC-specific epigenetic landscape as a driver of the age-dependent decline in adult neurogenesis. In this review, we summarize the recently accumulating evidence for a role of epigenetic dysregulation in NSC aging and propose perspectives for future research directions.
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650 _ 7 |a DNA methylation
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650 _ 7 |a Lamin B1
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650 _ 7 |a aging
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650 _ 7 |a chromatin
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650 _ 7 |a epigenetic
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650 _ 7 |a hippocampus
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650 _ 7 |a histone
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650 _ 7 |a neural stem cells
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650 _ 7 |a neurogenesis
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650 _ 2 |a Neurogenesis: physiology
|2 MeSH
650 _ 2 |a Cell Differentiation: genetics
|2 MeSH
650 _ 2 |a Neurons: metabolism
|2 MeSH
650 _ 2 |a Hippocampus: physiology
|2 MeSH
650 _ 2 |a Epigenesis, Genetic
|2 MeSH
700 1 _ |a Toda, Tomohisa
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770 _ _ |a Adult Neurogenesis in the Hippocampus
773 _ _ |a 10.1002/hipo.23494
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856 4 _ |u https://pub.dzne.de/record/169366/files/DZNE-2023-00141.pdf
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910 1 _ |a Deutsches Zentrum für Neurodegenerative Erkrankungen
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910 1 _ |a Deutsches Zentrum für Neurodegenerative Erkrankungen
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