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| Home > Publications Database > Serum IL-6, sAXL, and YKL-40 as systemic correlates of reduced brain structure and function in Alzheimer's disease: results from the DELCODE study. > print |
| Home > Publications Database > Serum IL-6, sAXL, and YKL-40 as systemic correlates of reduced brain structure and function in Alzheimer's disease: results from the DELCODE study. > print |
| 001 | 169379 | ||
| 005 | 20240826165949.0 | ||
| 024 | 7 | _ | |a 10.1186/s13195-022-01118-0 |2 doi |
| 024 | 7 | _ | |a pmid:36631909 |2 pmid |
| 024 | 7 | _ | |a pmc:PMC9835320 |2 pmc |
| 024 | 7 | _ | |a altmetric:141142629 |2 altmetric |
| 037 | _ | _ | |a DZNE-2023-00143 |
| 041 | _ | _ | |a English |
| 082 | _ | _ | |a 610 |
| 100 | 1 | _ | |a Brosseron, Frederic |0 P:(DE-2719)2810593 |b 0 |e First author |
| 245 | _ | _ | |a Serum IL-6, sAXL, and YKL-40 as systemic correlates of reduced brain structure and function in Alzheimer's disease: results from the DELCODE study. |
| 260 | _ | _ | |a London |c 2023 |b BioMed Central |
| 336 | 7 | _ | |a article |2 DRIVER |
| 336 | 7 | _ | |a Output Types/Journal article |2 DataCite |
| 336 | 7 | _ | |a Journal Article |b journal |m journal |0 PUB:(DE-HGF)16 |s 1709647383_29109 |2 PUB:(DE-HGF) |
| 336 | 7 | _ | |a ARTICLE |2 BibTeX |
| 336 | 7 | _ | |a JOURNAL_ARTICLE |2 ORCID |
| 336 | 7 | _ | |a Journal Article |0 0 |2 EndNote |
| 520 | _ | _ | |a Neuroinflammation constitutes a pathological hallmark of Alzheimer's disease (AD). Still, it remains unresolved if peripheral inflammatory markers can be utilized for research purposes similar to blood-based beta-amyloid and neurodegeneration measures. We investigated experimental inflammation markers in serum and analyzed interrelations towards AD pathology features in a cohort with a focus on at-risk stages of AD.Data of 74 healthy controls (HC), 99 subjective cognitive decline (SCD), 75 mild cognitive impairment (MCI), 23 AD relatives, and 38 AD subjects were obtained from the DELCODE cohort. A panel of 20 serum biomarkers was determined using immunoassays. Analyses were adjusted for age, sex, APOE status, and body mass index and included correlations between serum and CSF marker levels and AD biomarker levels. Group-wise comparisons were based on screening diagnosis and routine AD biomarker-based schematics. Structural imaging data were combined into composite scores representing Braak stage regions and related to serum biomarker levels. The Preclinical Alzheimer's Cognitive Composite (PACC5) score was used to test for associations between the biomarkers and cognitive performance.Each experimental marker displayed an individual profile of interrelations to AD biomarkers, imaging, or cognition features. Serum-soluble AXL (sAXL), IL-6, and YKL-40 showed the most striking associations. Soluble AXL was significantly elevated in AD subjects with pathological CSF beta-amyloid/tau profile and negatively related to structural imaging and cognitive function. Serum IL-6 was negatively correlated to structural measures of Braak regions, without associations to corresponding IL-6 CSF levels or other AD features. Serum YKL-40 correlated most consistently to CSF AD biomarker profiles and showed the strongest negative relations to structure, but none to cognitive outcomes.Serum sAXL, IL-6, and YKL-40 relate to different AD features, including the degree of neuropathology and cognitive functioning. This may suggest that peripheral blood signatures correspond to specific stages of the disease. As serum markers did not reflect the corresponding CSF protein levels, our data highlight the need to interpret serum inflammatory markers depending on the respective protein's specific biology and cellular origin. These marker-specific differences will have to be considered to further define and interpret blood-based inflammatory profiles for AD research. |
| 536 | _ | _ | |a 353 - Clinical and Health Care Research (POF4-353) |0 G:(DE-HGF)POF4-353 |c POF4-353 |f POF IV |x 0 |
| 536 | _ | _ | |a 352 - Disease Mechanisms (POF4-352) |0 G:(DE-HGF)POF4-352 |c POF4-352 |f POF IV |x 1 |
| 536 | _ | _ | |a 351 - Brain Function (POF4-351) |0 G:(DE-HGF)POF4-351 |c POF4-351 |f POF IV |x 2 |
| 588 | _ | _ | |a Dataset connected to CrossRef, PubMed, , Journals: pub.dzne.de |
| 650 | _ | 7 | |a Alzheimer’s disease |2 Other |
| 650 | _ | 7 | |a Alzheimer’s disease |2 Other |
| 650 | _ | 7 | |a Biomarker |2 Other |
| 650 | _ | 7 | |a Blood-based |2 Other |
| 650 | _ | 7 | |a Cognition |2 Other |
| 650 | _ | 7 | |a Inflammation |2 Other |
| 650 | _ | 7 | |a Structural MRI |2 Other |
| 650 | _ | 7 | |a Interleukin-6 |2 NLM Chemicals |
| 650 | _ | 7 | |a Chitinase-3-Like Protein 1 |2 NLM Chemicals |
| 650 | _ | 7 | |a Amyloid beta-Peptides |2 NLM Chemicals |
| 650 | _ | 7 | |a Biomarkers |2 NLM Chemicals |
| 650 | _ | 7 | |a tau Proteins |2 NLM Chemicals |
| 650 | _ | 7 | |a AXL protein, human |2 NLM Chemicals |
| 650 | _ | 2 | |a Alzheimer Disease: blood |2 MeSH |
| 650 | _ | 2 | |a Humans |2 MeSH |
| 650 | _ | 2 | |a Alzheimer Disease: pathology |2 MeSH |
| 650 | _ | 2 | |a Interleukin-6 |2 MeSH |
| 650 | _ | 2 | |a Chitinase-3-Like Protein 1 |2 MeSH |
| 650 | _ | 2 | |a Amyloid beta-Peptides |2 MeSH |
| 650 | _ | 2 | |a Brain: pathology |2 MeSH |
| 650 | _ | 2 | |a Cognitive Dysfunction: diagnosis |2 MeSH |
| 650 | _ | 2 | |a Biomarkers |2 MeSH |
| 650 | _ | 2 | |a tau Proteins |2 MeSH |
| 650 | _ | 2 | |a Amyloid beta-Peptides: cerebrospinal fluid |2 MeSH |
| 650 | _ | 2 | |a Biomarkers: blood |2 MeSH |
| 650 | _ | 2 | |a Chitinase-3-Like Protein 1: blood |2 MeSH |
| 650 | _ | 2 | |a Cognitive Dysfunction: blood |2 MeSH |
| 650 | _ | 2 | |a Interleukin-6: blood |2 MeSH |
| 650 | _ | 2 | |a tau Proteins: cerebrospinal fluid |2 MeSH |
| 693 | _ | _ | |0 EXP:(DE-2719)DELCODE-20140101 |5 EXP:(DE-2719)DELCODE-20140101 |e Longitudinal Cognitive Impairment and Dementia Study |x 0 |
| 700 | 1 | _ | |a Maass, Anne |0 P:(DE-2719)2811815 |b 1 |
| 700 | 1 | _ | |a Kleineidam, Luca |0 P:(DE-2719)2812139 |b 2 |
| 700 | 1 | _ | |a Ravichandran, Kishore Aravind |0 P:(DE-2719)9002244 |b 3 |
| 700 | 1 | _ | |a Kolbe, Carl-Christian |b 4 |
| 700 | 1 | _ | |a Wolfsgruber, Steffen |0 P:(DE-2719)2810544 |b 5 |
| 700 | 1 | _ | |a Santarelli, Francesco |0 P:(DE-2719)2810567 |b 6 |
| 700 | 1 | _ | |a Häsler, Lisa M |0 P:(DE-2719)2811581 |b 7 |
| 700 | 1 | _ | |a McManus, Róisín |0 P:(DE-2719)2811671 |b 8 |
| 700 | 1 | _ | |a Ising, Christina |0 P:(DE-2719)2812463 |b 9 |
| 700 | 1 | _ | |a Röske, Sandra |0 P:(DE-2719)2810395 |b 10 |
| 700 | 1 | _ | |a Peters, Oliver |0 P:(DE-2719)2811024 |b 11 |
| 700 | 1 | _ | |a Cosma, Nicoleta-Carmen |0 P:(DE-2719)9002259 |b 12 |
| 700 | 1 | _ | |a Schneider, Luisa-Sophie |0 P:(DE-2719)9002878 |b 13 |u dzne |
| 700 | 1 | _ | |a Wang, Xiao |b 14 |
| 700 | 1 | _ | |a Priller, Josef |0 P:(DE-2719)2811122 |b 15 |
| 700 | 1 | _ | |a Spruth, Eike J |0 P:(DE-2719)2812446 |b 16 |
| 700 | 1 | _ | |a Altenstein, Slawek |0 P:(DE-2719)2811720 |b 17 |
| 700 | 1 | _ | |a Schneider, Anja |0 P:(DE-2719)2812035 |b 18 |
| 700 | 1 | _ | |a Fliessbach, Klaus |0 P:(DE-2719)2811326 |b 19 |
| 700 | 1 | _ | |a Wiltfang, Jens |0 P:(DE-2719)2811317 |b 20 |
| 700 | 1 | _ | |a Schott, Björn H |0 P:(DE-2719)2814326 |b 21 |
| 700 | 1 | _ | |a Buerger, Katharina |0 P:(DE-2719)2811351 |b 22 |
| 700 | 1 | _ | |a Janowitz, Daniel |0 P:(DE-2719)9002557 |b 23 |
| 700 | 1 | _ | |a Dichgans, Martin |0 P:(DE-2719)2000030 |b 24 |
| 700 | 1 | _ | |a Perneczky, Robert |0 P:(DE-2719)2812234 |b 25 |
| 700 | 1 | _ | |a Rauchmann, Boris-Stephan |0 P:(DE-2719)9001808 |b 26 |
| 700 | 1 | _ | |a Teipel, Stefan |0 P:(DE-2719)2000026 |b 27 |
| 700 | 1 | _ | |a Kilimann, Ingo |0 P:(DE-2719)2810394 |b 28 |
| 700 | 1 | _ | |a Görß, Doreen |0 P:(DE-2719)2812583 |b 29 |
| 700 | 1 | _ | |a Laske, Christoph |0 P:(DE-2719)2000055 |b 30 |
| 700 | 1 | _ | |a Munk, Matthias H |0 P:(DE-2719)9001516 |b 31 |
| 700 | 1 | _ | |a Düzel, Emrah |0 P:(DE-2719)2000005 |b 32 |
| 700 | 1 | _ | |a Yakupov, Renat |0 P:(DE-2719)2812398 |b 33 |
| 700 | 1 | _ | |a Dobisch, Laura |0 P:(DE-2719)2811611 |b 34 |
| 700 | 1 | _ | |a Metzger, Coraline D |0 P:(DE-2719)9000443 |b 35 |
| 700 | 1 | _ | |a Glanz, Wenzel |0 P:(DE-2719)2811614 |b 36 |
| 700 | 1 | _ | |a Ewers, Michael |0 P:(DE-2719)9000543 |b 37 |
| 700 | 1 | _ | |a Dechent, Peter |b 38 |
| 700 | 1 | _ | |a Haynes, John Dylan |b 39 |
| 700 | 1 | _ | |a Scheffler, Klaus |b 40 |
| 700 | 1 | _ | |a Roy, Nina |0 P:(DE-2719)2812341 |b 41 |
| 700 | 1 | _ | |a Rostamzadeh, Ayda |b 42 |
| 700 | 1 | _ | |a Spottke, Annika |0 P:(DE-2719)2811324 |b 43 |
| 700 | 1 | _ | |a Ramirez, Alfredo |0 P:(DE-2719)2812825 |b 44 |
| 700 | 1 | _ | |a Mengel, David |0 P:(DE-2719)9000375 |b 45 |
| 700 | 1 | _ | |a Synofzik, Matthis |0 P:(DE-2719)2811275 |b 46 |
| 700 | 1 | _ | |a Jucker, Mathias |0 P:(DE-2719)2000010 |b 47 |
| 700 | 1 | _ | |a Latz, Eicke |0 P:(DE-2719)2000062 |b 48 |
| 700 | 1 | _ | |a Jessen, Frank |0 P:(DE-2719)2000032 |b 49 |
| 700 | 1 | _ | |a Wagner, Michael |0 P:(DE-2719)2000057 |b 50 |
| 700 | 1 | _ | |a Heneka, Michael T |0 P:(DE-2719)2000008 |b 51 |e Last author |
| 700 | 1 | _ | |a group, DELCODE study |b 52 |e Collaboration Author |
| 773 | _ | _ | |a 10.1186/s13195-022-01118-0 |g Vol. 15, no. 1, p. 13 |0 PERI:(DE-600)2506521-X |n 1 |p 13 |t Alzheimer's research & therapy |v 15 |y 2023 |x 1758-9193 |
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