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000169388 0247_ $$2datacite_doi$$a10.60944/DZNE-2023-00152
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000169388 1001_ $$0P:(DE-2719)9000927$$aDjannatian, Minou$$b0$$eFirst author$$udzne
000169388 245__ $$aMyelination generates aberrant ultrastructure that is resolved by microglia.
000169388 260__ $$aNew York, NY$$bRockefeller Univ. Press$$c2023
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000169388 520__ $$aTo enable rapid propagation of action potentials, axons are ensheathed by myelin, a multilayered insulating membrane formed by oligodendrocytes. Most of the myelin is generated early in development, resulting in the generation of long-lasting stable membrane structures. Here, we explored structural and dynamic changes in central nervous system myelin during development. To achieve this, we performed an ultrastructural analysis of mouse optic nerves by serial block face scanning electron microscopy (SBF-SEM) and confocal time-lapse imaging in the zebrafish spinal cord. We found that myelin undergoes extensive ultrastructural changes during early postnatal development. Myelin degeneration profiles were engulfed and phagocytosed by microglia using exposed phosphatidylserine as one 'eat me' signal. In contrast, retractions of entire myelin sheaths occurred independently of microglia and involved uptake of myelin by the oligodendrocyte itself. Our findings show that the generation of myelin early in development is an inaccurate process associated with aberrant ultrastructural features that require substantial refinement.
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000169388 650_2 $$2MeSH$$aAnimals
000169388 650_2 $$2MeSH$$aMice
000169388 650_2 $$2MeSH$$aAxons: ultrastructure
000169388 650_2 $$2MeSH$$aMicroglia: ultrastructure
000169388 650_2 $$2MeSH$$aMyelin Sheath: ultrastructure
000169388 650_2 $$2MeSH$$aOligodendroglia: ultrastructure
000169388 650_2 $$2MeSH$$aZebrafish
000169388 650_2 $$2MeSH$$aOptic Nerve: ultrastructure
000169388 650_2 $$2MeSH$$aMicroscopy, Electron, Scanning
000169388 650_2 $$2MeSH$$aPhagocytosis
000169388 650_2 $$2MeSH$$aTime-Lapse Imaging
000169388 7001_ $$0P:(DE-2719)9001887$$aRadha, Swathi$$b1$$udzne
000169388 7001_ $$00000-0001-9988-5299$$aWeikert, Ulrich$$b2
000169388 7001_ $$0P:(DE-2719)9000734$$aSafaiyani, Shima$$b3$$udzne
000169388 7001_ $$00000-0001-7461-6965$$aWrede, Christoph$$b4
000169388 7001_ $$0P:(DE-2719)9000525$$aDeichsel, Cassandra$$b5$$udzne
000169388 7001_ $$0P:(DE-2719)9000614$$aKislinger, Georg$$b6$$udzne
000169388 7001_ $$00000-0002-5323-210X$$aRhomberg, Agata$$b7
000169388 7001_ $$00000-0002-9535-9395$$aRuhwedel, Torben$$b8
000169388 7001_ $$00000-0002-7371-9484$$aCampbell, Douglas S$$b9
000169388 7001_ $$00000-0002-2175-8713$$avan Ham, Tjakko$$b10
000169388 7001_ $$0P:(DE-2719)2241638$$aSchmid, Bettina$$b11$$udzne
000169388 7001_ $$00000-0001-7893-8507$$aHegermann, Jan$$b12
000169388 7001_ $$00000-0002-2902-7165$$aMöbius, Wiebke$$b13
000169388 7001_ $$0P:(DE-2719)2812260$$aSchifferer, Martina$$b14$$udzne
000169388 7001_ $$0P:(DE-2719)2811642$$aSimons, Mikael$$b15$$udzne
000169388 773__ $$0PERI:(DE-600)1421310-2$$a10.1083/jcb.202204010$$gVol. 222, no. 3, p. e202204010$$n3$$pe202204010$$tThe journal of cell biology$$v222$$x0021-9525$$y2023
000169388 8564_ $$uhttps://pub.dzne.de/record/169388/files/DZNE-2023-00152.pdf$$yPublished on 2023-01-13. Available in OpenAccess from 2023-07-13.
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