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@ARTICLE{Djannatian:169388,
      author       = {Djannatian, Minou and Radha, Swathi and Weikert, Ulrich and
                      Safaiyani, Shima and Wrede, Christoph and Deichsel,
                      Cassandra and Kislinger, Georg and Rhomberg, Agata and
                      Ruhwedel, Torben and Campbell, Douglas S and van Ham, Tjakko
                      and Schmid, Bettina and Hegermann, Jan and Möbius, Wiebke
                      and Schifferer, Martina and Simons, Mikael},
      title        = {{M}yelination generates aberrant ultrastructure that is
                      resolved by microglia.},
      journal      = {The journal of cell biology},
      volume       = {222},
      number       = {3},
      issn         = {0021-9525},
      address      = {New York, NY},
      publisher    = {Rockefeller Univ. Press},
      reportid     = {DZNE-2023-00152},
      pages        = {e202204010},
      year         = {2023},
      abstract     = {To enable rapid propagation of action potentials, axons are
                      ensheathed by myelin, a multilayered insulating membrane
                      formed by oligodendrocytes. Most of the myelin is generated
                      early in development, resulting in the generation of
                      long-lasting stable membrane structures. Here, we explored
                      structural and dynamic changes in central nervous system
                      myelin during development. To achieve this, we performed an
                      ultrastructural analysis of mouse optic nerves by serial
                      block face scanning electron microscopy (SBF-SEM) and
                      confocal time-lapse imaging in the zebrafish spinal cord. We
                      found that myelin undergoes extensive ultrastructural
                      changes during early postnatal development. Myelin
                      degeneration profiles were engulfed and phagocytosed by
                      microglia using exposed phosphatidylserine as one 'eat me'
                      signal. In contrast, retractions of entire myelin sheaths
                      occurred independently of microglia and involved uptake of
                      myelin by the oligodendrocyte itself. Our findings show that
                      the generation of myelin early in development is an
                      inaccurate process associated with aberrant ultrastructural
                      features that require substantial refinement.},
      keywords     = {Animals / Mice / Axons: ultrastructure / Microglia:
                      ultrastructure / Myelin Sheath: ultrastructure /
                      Oligodendroglia: ultrastructure / Zebrafish / Optic Nerve:
                      ultrastructure / Microscopy, Electron, Scanning /
                      Phagocytosis / Time-Lapse Imaging},
      cin          = {AG Simons / AG Misgeld / AG Schmid},
      ddc          = {570},
      cid          = {I:(DE-2719)1110008 / I:(DE-2719)1110000-4 /
                      I:(DE-2719)1140002},
      pnm          = {351 - Brain Function (POF4-351) / 352 - Disease Mechanisms
                      (POF4-352)},
      pid          = {G:(DE-HGF)POF4-351 / G:(DE-HGF)POF4-352},
      typ          = {PUB:(DE-HGF)16},
      pmc          = {pmc:PMC9856851},
      pubmed       = {pmid:36637807},
      doi          = {10.1083/jcb.202204010},
      url          = {https://pub.dzne.de/record/169388},
}