Home > Publications Database > Myelination generates aberrant ultrastructure that is resolved by microglia. > print

001     169388
005     20240611120548.0
024 7 _ |a pmc:PMC9856851
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024 7 _ |a 10.1083/jcb.202204010
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024 7 _ |a 0021-9525
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024 7 _ |a 0095-9901
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024 7 _ |a 1540-8140
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024 7 _ |a 2327-7440
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024 7 _ |a altmetric:141250301
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024 7 _ |a 10.60944/DZNE-2023-00152
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037 _ _ |a DZNE-2023-00152
041 _ _ |a English
082 _ _ |a 570
100 1 _ |a Djannatian, Minou
|0 P:(DE-2719)9000927
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245 _ _ |a Myelination generates aberrant ultrastructure that is resolved by microglia.
260 _ _ |a New York, NY
|c 2023
|b Rockefeller Univ. Press
336 7 _ |a article
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520 _ _ |a To enable rapid propagation of action potentials, axons are ensheathed by myelin, a multilayered insulating membrane formed by oligodendrocytes. Most of the myelin is generated early in development, resulting in the generation of long-lasting stable membrane structures. Here, we explored structural and dynamic changes in central nervous system myelin during development. To achieve this, we performed an ultrastructural analysis of mouse optic nerves by serial block face scanning electron microscopy (SBF-SEM) and confocal time-lapse imaging in the zebrafish spinal cord. We found that myelin undergoes extensive ultrastructural changes during early postnatal development. Myelin degeneration profiles were engulfed and phagocytosed by microglia using exposed phosphatidylserine as one 'eat me' signal. In contrast, retractions of entire myelin sheaths occurred independently of microglia and involved uptake of myelin by the oligodendrocyte itself. Our findings show that the generation of myelin early in development is an inaccurate process associated with aberrant ultrastructural features that require substantial refinement.
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650 _ 2 |a Animals
|2 MeSH
650 _ 2 |a Mice
|2 MeSH
650 _ 2 |a Axons: ultrastructure
|2 MeSH
650 _ 2 |a Microglia: ultrastructure
|2 MeSH
650 _ 2 |a Myelin Sheath: ultrastructure
|2 MeSH
650 _ 2 |a Oligodendroglia: ultrastructure
|2 MeSH
650 _ 2 |a Zebrafish
|2 MeSH
650 _ 2 |a Optic Nerve: ultrastructure
|2 MeSH
650 _ 2 |a Microscopy, Electron, Scanning
|2 MeSH
650 _ 2 |a Phagocytosis
|2 MeSH
650 _ 2 |a Time-Lapse Imaging
|2 MeSH
700 1 _ |a Radha, Swathi
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700 1 _ |a Weikert, Ulrich
|0 0000-0001-9988-5299
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700 1 _ |a Safaiyani, Shima
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700 1 _ |a Wrede, Christoph
|0 0000-0001-7461-6965
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700 1 _ |a Deichsel, Cassandra
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700 1 _ |a Kislinger, Georg
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700 1 _ |a Rhomberg, Agata
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700 1 _ |a Ruhwedel, Torben
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700 1 _ |a Campbell, Douglas S
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700 1 _ |a van Ham, Tjakko
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700 1 _ |a Schmid, Bettina
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700 1 _ |a Hegermann, Jan
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700 1 _ |a Möbius, Wiebke
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700 1 _ |a Schifferer, Martina
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700 1 _ |a Simons, Mikael
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773 _ _ |a 10.1083/jcb.202204010
|g Vol. 222, no. 3, p. e202204010
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|p e202204010
|t The journal of cell biology
|v 222
|y 2023
|x 0021-9525
856 4 _ |u https://pub.dzne.de/record/169388/files/DZNE-2023-00152.pdf
|y Published on 2023-01-13. Available in OpenAccess from 2023-07-13.
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|y Published on 2023-01-13. Available in OpenAccess from 2023-07-13.
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