000194973 001__ 194973
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000194973 037__ $$aDZNE-2023-00160
000194973 041__ $$aEnglish
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000194973 1001_ $$aEhrenberg, Alexander J$$b0
000194973 245__ $$aPriorities for research on neuromodulatory subcortical systems in Alzheimer's disease: Position paper from the NSS PIA of ISTAART.
000194973 260__ $$aHoboken, NJ$$bWiley$$c2023
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000194973 520__ $$aThe neuromodulatory subcortical system (NSS) nuclei are critical hubs for survival, hedonic tone, and homeostasis. Tau-associated NSS degeneration occurs early in Alzheimer's disease (AD) pathogenesis, long before the emergence of pathognomonic memory dysfunction and cortical lesions. Accumulating evidence supports the role of NSS dysfunction and degeneration in the behavioral and neuropsychiatric manifestations featured early in AD. Experimental studies even suggest that AD-associated NSS degeneration drives brain neuroinflammatory status and contributes to disease progression, including the exacerbation of cortical lesions. Given the important pathophysiologic and etiologic roles that involve the NSS in early AD stages, there is an urgent need to expand our understanding of the mechanisms underlying NSS vulnerability and more precisely detail the clinical progression of NSS changes in AD. Here, the NSS Professional Interest Area of the International Society to Advance Alzheimer's Research and Treatment highlights knowledge gaps about NSS within AD and provides recommendations for priorities specific to clinical research, biomarker development, modeling, and intervention. HIGHLIGHTS: Neuromodulatory nuclei degenerate in early Alzheimer's disease pathological stages. Alzheimer's pathophysiology is exacerbated by neuromodulatory nuclei degeneration. Neuromodulatory nuclei degeneration drives neuropsychiatric symptoms in dementia. Biomarkers of neuromodulatory integrity would be value-creating for dementia care. Neuromodulatory nuclei present strategic prospects for disease-modifying therapies.
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000194973 650_7 $$2NLM Chemicals$$aBiomarkers
000194973 650_2 $$2MeSH$$aHumans
000194973 650_2 $$2MeSH$$aAlzheimer Disease: pathology
000194973 650_2 $$2MeSH$$aBrain: pathology
000194973 650_2 $$2MeSH$$aBiomarkers
000194973 650_2 $$2MeSH$$aDisease Progression
000194973 7001_ $$aKelberman, Michael A$$b1
000194973 7001_ $$0P:(DE-HGF)0$$aLiu, Kathy Y$$b2
000194973 7001_ $$aDahl, Martin J$$b3
000194973 7001_ $$aWeinshenker, David$$b4
000194973 7001_ $$aFalgàs, Neus$$b5
000194973 7001_ $$aDutt, Shubir$$b6
000194973 7001_ $$aMather, Mara$$b7
000194973 7001_ $$0P:(DE-2719)9002575$$aLudwig, Mareike$$b8$$udzne
000194973 7001_ $$0P:(DE-2719)2810555$$aBetts, Matthew J$$b9
000194973 7001_ $$aWiner, Joseph R$$b10
000194973 7001_ $$0P:(DE-2719)2000026$$aTeipel, Stefan$$b11
000194973 7001_ $$aWeigand, Alexandra J$$b12
000194973 7001_ $$aEschenko, Oxana$$b13
000194973 7001_ $$0P:(DE-2719)2811927$$aHämmerer, Dorothea$$b14
000194973 7001_ $$0P:(DE-2719)9001927$$aLeiman Algranati, Marina$$b15
000194973 7001_ $$aCounts, Scott E$$b16
000194973 7001_ $$aShine, James M$$b17
000194973 7001_ $$aRobertson, Ian H$$b18
000194973 7001_ $$aLevey, Allan I$$b19
000194973 7001_ $$0P:(DE-2719)9002565$$aLancini, Elisa$$b20$$udzne
000194973 7001_ $$aSon, Gowoon$$b21
000194973 7001_ $$aSchneider, Chrisoph$$b22
000194973 7001_ $$aEgroo, Maxime Van$$b23
000194973 7001_ $$aLiguori, Claudio$$b24
000194973 7001_ $$0P:(DE-HGF)0$$aWang, Qin$$b25
000194973 7001_ $$aVazey, Elena M$$b26
000194973 7001_ $$aRodriguez-Porcel, Federico$$b27
000194973 7001_ $$0P:(DE-2719)9002566$$aHaag, Lena$$b28$$udzne
000194973 7001_ $$aBondi, Mark W$$b29
000194973 7001_ $$aVanneste, Sven$$b30
000194973 7001_ $$aFreeze, Whitney M$$b31
000194973 7001_ $$0P:(DE-2719)9002257$$aYi, Yeo-Jin$$b32
000194973 7001_ $$aMaldinov, Mihovil$$b33
000194973 7001_ $$aGatchel, Jennifer$$b34
000194973 7001_ $$aSatpati, Abhijit$$b35
000194973 7001_ $$aBabiloni, Claudio$$b36
000194973 7001_ $$aKremen, William S$$b37
000194973 7001_ $$aHoward, Robert$$b38
000194973 7001_ $$aJacobs, Heidi I L$$b39
000194973 7001_ $$aGrinberg, Lea T$$b40
000194973 773__ $$0PERI:(DE-600)2201940-6$$a10.1002/alz.12937$$gp. alz.12937$$n5$$p2182-2196$$tAlzheimer's and dementia$$v19$$x1552-5260$$y2023
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