000195002 001__ 195002
000195002 005__ 20250127125013.0
000195002 037__ $$aDZNE-2023-00185
000195002 1001_ $$0P:(DE-2719)2810938$$aMüller, Stephan A$$b0$$eCorresponding author$$udzne
000195002 245__ $$aDataset: Cerebrospinal Fluid (CSF) Proteomics of APPPS1 mice
000195002 260__ $$bPRoteomics IDEntifications Database$$c2022
000195002 3367_ $$2BibTeX$$aMISC
000195002 3367_ $$0PUB:(DE-HGF)32$$2PUB:(DE-HGF)$$aDataset$$bdataset$$mdataset$$s1737978599_25456
000195002 3367_ $$026$$2EndNote$$aChart or Table
000195002 3367_ $$2DataCite$$aDataset
000195002 3367_ $$2ORCID$$aDATA_SET
000195002 3367_ $$2DINI$$aResearchData
000195002 520__ $$aHere, we took advantage of well-defined mouse models for β-amyloidosis (APPPS1) to explore proteome changes in the cerebrospinal fluid which are related to these distinct proteopathic lesions. Non-targeted liquid chromatography-mass spectrometry revealed that the majority of proteins that undergo age- and disease-related changes in either mouse model was linked to microglia, and more specifically to previously described disease state-specific microglia transcriptomic signatures. The finding that such transcriptomic changes translate into corresponding protein changes in cerebrospinal fluid is of high clinical relevance, supporting efforts to identify bodily fluid biomarkers that reflect the various functional states of microglial activation in Alzheimer’s disease.
000195002 536__ $$0G:(DE-HGF)POF4-352$$a352 - Disease Mechanisms (POF4-352)$$cPOF4-352$$fPOF IV$$x0
000195002 7001_ $$0P:(DE-2719)2181459$$aLichtenthaler, Stefan$$b1$$eCorresponding author$$udzne
000195002 7870_ $$0DZNE-2022-01184$$aEninger, Timo et.al.$$dWashington, DC : National Acad. of Sciences, 2022$$iRelatedTo$$r$$tSignatures of glial activity can be detected in the CSF proteome
000195002 8564_ $$uhttps://www.ebi.ac.uk/pride/archive/projects/PXD021322
000195002 909CO $$ooai:pub.dzne.de:195002$$pVDB
000195002 9101_ $$0I:(DE-588)1065079516$$6P:(DE-2719)2810938$$aDeutsches Zentrum für Neurodegenerative Erkrankungen$$b0$$kDZNE
000195002 9101_ $$0I:(DE-588)1065079516$$6P:(DE-2719)2181459$$aDeutsches Zentrum für Neurodegenerative Erkrankungen$$b1$$kDZNE
000195002 9131_ $$0G:(DE-HGF)POF4-352$$1G:(DE-HGF)POF4-350$$2G:(DE-HGF)POF4-300$$3G:(DE-HGF)POF4$$4G:(DE-HGF)POF$$aDE-HGF$$bGesundheit$$lNeurodegenerative Diseases$$vDisease Mechanisms$$x0
000195002 9141_ $$y2022
000195002 9201_ $$0I:(DE-2719)1110006$$kAG Lichtenthaler$$lNeuroproteomics$$x0
000195002 980__ $$adataset
000195002 980__ $$aVDB
000195002 980__ $$aI:(DE-2719)1110006
000195002 980__ $$aUNRESTRICTED