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001     195002
005     20250127125013.0
037 _ _ |a DZNE-2023-00185
100 1 _ |a Müller, Stephan A
|0 P:(DE-2719)2810938
|b 0
|e Corresponding author
|u dzne
245 _ _ |a Dataset: Cerebrospinal Fluid (CSF) Proteomics of APPPS1 mice
260 _ _ |c 2022
|b PRoteomics IDEntifications Database
336 7 _ |a MISC
|2 BibTeX
336 7 _ |a Dataset
|b dataset
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|0 PUB:(DE-HGF)32
|s 1737978599_25456
|2 PUB:(DE-HGF)
336 7 _ |a Chart or Table
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|2 EndNote
336 7 _ |a Dataset
|2 DataCite
336 7 _ |a DATA_SET
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336 7 _ |a ResearchData
|2 DINI
520 _ _ |a Here, we took advantage of well-defined mouse models for β-amyloidosis (APPPS1) to explore proteome changes in the cerebrospinal fluid which are related to these distinct proteopathic lesions. Non-targeted liquid chromatography-mass spectrometry revealed that the majority of proteins that undergo age- and disease-related changes in either mouse model was linked to microglia, and more specifically to previously described disease state-specific microglia transcriptomic signatures. The finding that such transcriptomic changes translate into corresponding protein changes in cerebrospinal fluid is of high clinical relevance, supporting efforts to identify bodily fluid biomarkers that reflect the various functional states of microglial activation in Alzheimer’s disease.
536 _ _ |a 352 - Disease Mechanisms (POF4-352)
|0 G:(DE-HGF)POF4-352
|c POF4-352
|f POF IV
|x 0
700 1 _ |a Lichtenthaler, Stefan
|0 P:(DE-2719)2181459
|b 1
|e Corresponding author
|u dzne
787 0 _ |a Eninger, Timo et.al.
|d Washington, DC : National Acad. of Sciences, 2022
|i RelatedTo
|0 DZNE-2022-01184
|r
|t Signatures of glial activity can be detected in the CSF proteome
856 4 _ |u https://www.ebi.ac.uk/pride/archive/projects/PXD021322
909 C O |p VDB
|o oai:pub.dzne.de:195002
910 1 _ |a Deutsches Zentrum für Neurodegenerative Erkrankungen
|0 I:(DE-588)1065079516
|k DZNE
|b 0
|6 P:(DE-2719)2810938
910 1 _ |a Deutsches Zentrum für Neurodegenerative Erkrankungen
|0 I:(DE-588)1065079516
|k DZNE
|b 1
|6 P:(DE-2719)2181459
913 1 _ |a DE-HGF
|b Gesundheit
|l Neurodegenerative Diseases
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|0 G:(DE-HGF)POF4-352
|3 G:(DE-HGF)POF4
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|v Disease Mechanisms
|x 0
914 1 _ |y 2022
920 1 _ |0 I:(DE-2719)1110006
|k AG Lichtenthaler
|l Neuroproteomics
|x 0
980 _ _ |a dataset
980 _ _ |a VDB
980 _ _ |a I:(DE-2719)1110006
980 _ _ |a UNRESTRICTED

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