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000247521 0247_ $$2doi$$a10.1016/j.neurobiolaging.2022.12.005
000247521 0247_ $$2pmid$$apmid:36706574
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000247521 037__ $$aDZNE-2023-00198
000247521 041__ $$aEnglish
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000247521 1001_ $$0P:(DE-2719)9000476$$aBallarini, Tommaso$$b0$$eFirst author$$udzne
000247521 245__ $$aLinking early-life bilingualism and cognitive advantage in older adulthood.
000247521 260__ $$aAmsterdam [u.a.]$$bElsevier Science$$c2023
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000247521 520__ $$aPrevious studies have identified bilingualism as a protective factor against dementia. Here we aimed to test whether being bilingual at different life stages impacts cognition and brain structure in older adulthood. We included 746 participants from the DZNE-Longitudinal Cognitive Impairment and Dementia Study (DELCODE). Assessment of bilingualism at 3 life stages (early: 13-30, middle: 30-65 and late: over 65 years old) was determined with the Lifetime of Experiences Questionnaire. Individuals reporting bilingualism (i.e., daily use of L2) in the early life stage outperformed monolinguals on learning & memory, working-memory, executive functions and language. Bilingualism in middle life stage showed a significant advantage on learning & memory, while no effect of bilingualism in old life stage was identified. Brain gray matter volume was not associated with L2 use and did not differ between groups. However, stronger correlations between brain gray matter volume in selected brain regions and cognitive performance were found in bilingual participants in the early and middle life stages. Our results indicate that bilingualism in early life might provide a long-lasting protective effect on cognition and shape the brain to sustain cognitive performance in older adulthood.
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000247521 650_7 $$2Other$$aAging
000247521 650_7 $$2Other$$aBilingualism
000247521 650_7 $$2Other$$aBrain structure
000247521 650_7 $$2Other$$aNeuropsychology
000247521 650_7 $$2Other$$aVoxel-based-morphometry
000247521 650_2 $$2MeSH$$aHumans
000247521 650_2 $$2MeSH$$aAged
000247521 650_2 $$2MeSH$$aMultilingualism
000247521 650_2 $$2MeSH$$aCognition
000247521 650_2 $$2MeSH$$aExecutive Function
000247521 650_2 $$2MeSH$$aBrain
000247521 650_2 $$2MeSH$$aDementia
000247521 693__ $$0EXP:(DE-2719)DELCODE-20140101$$5EXP:(DE-2719)DELCODE-20140101$$eLongitudinal Cognitive Impairment and Dementia Study$$x0
000247521 7001_ $$0P:(DE-2719)9002169$$aKuhn, Elizabeth$$b1$$udzne
000247521 7001_ $$0P:(DE-2719)2810395$$aRöske, Sandra$$b2$$udzne
000247521 7001_ $$0P:(DE-2719)2811720$$aAltenstein, Slawek$$b3$$udzne
000247521 7001_ $$0P:(DE-HGF)0$$aBartels, Claudia$$b4
000247521 7001_ $$0P:(DE-HGF)0$$aBuchholz, Friederike$$b5
000247521 7001_ $$0P:(DE-2719)2811351$$aBuerger, Katharina$$b6$$udzne
000247521 7001_ $$0P:(DE-HGF)0$$aDechent, Peter$$b7
000247521 7001_ $$0P:(DE-2719)2811611$$aDobisch, Laura$$b8$$udzne
000247521 7001_ $$0P:(DE-2719)9000543$$aEwers, Michael$$b9$$udzne
000247521 7001_ $$0P:(DE-2719)2811326$$aFliessbach, Klaus$$b10$$udzne
000247521 7001_ $$0P:(DE-2719)2812392$$aFreiesleben, Silka Dawn$$b11$$udzne
000247521 7001_ $$0P:(DE-2719)2810481$$aFrommann, Ingo$$b12$$udzne
000247521 7001_ $$0P:(DE-2719)9000554$$aGabelin, Tatjana$$b13$$udzne
000247521 7001_ $$0P:(DE-2719)2811614$$aGlanz, Wenzel$$b14$$udzne
000247521 7001_ $$0P:(DE-2719)2812583$$aGörß, Doreen$$b15$$udzne
000247521 7001_ $$0P:(DE-HGF)0$$aHaynes, John Dylan$$b16
000247521 7001_ $$0P:(DE-2719)9001517$$aIncesoy, Enise I$$b17$$udzne
000247521 7001_ $$0P:(DE-2719)9002557$$aJanowitz, Daniel$$b18$$udzne
000247521 7001_ $$0P:(DE-2719)2810394$$aKilimann, Ingo$$b19$$udzne
000247521 7001_ $$0P:(DE-2719)2812139$$aKleineidam, Luca$$b20$$udzne
000247521 7001_ $$0P:(DE-2719)9001475$$aKobeleva, Xenia$$b21$$udzne
000247521 7001_ $$0P:(DE-2719)2000055$$aLaske, Christoph$$b22$$udzne
000247521 7001_ $$0P:(DE-2719)2811189$$aLohse, Andrea$$b23$$udzne
000247521 7001_ $$0P:(DE-HGF)0$$aMaier, Franziska$$b24
000247521 7001_ $$0P:(DE-2719)9001516$$aMunk, Matthias H$$b25$$udzne
000247521 7001_ $$0P:(DE-2719)2812234$$aPerneczky, Robert$$b26$$udzne
000247521 7001_ $$0P:(DE-2719)2811024$$aPeters, Oliver$$b27$$udzne
000247521 7001_ $$0P:(DE-2719)2811122$$aPriller, Josef$$b28$$udzne
000247521 7001_ $$0P:(DE-2719)9001808$$aRauchmann, Boris Stephan$$b29$$udzne
000247521 7001_ $$0P:(DE-2719)2812341$$aRoy, Nina$$b30$$udzne
000247521 7001_ $$0P:(DE-HGF)0$$aScheffler, Klaus$$b31
000247521 7001_ $$0P:(DE-2719)2812035$$aSchneider, Anja$$b32$$udzne
000247521 7001_ $$0P:(DE-2719)2814326$$aSchott, Björn H$$b33$$udzne
000247521 7001_ $$0P:(DE-2719)2811324$$aSpottke, Annika$$b34$$udzne
000247521 7001_ $$0P:(DE-2719)2812446$$aSpruth, Eike Jakob$$b35$$udzne
000247521 7001_ $$0P:(DE-2719)2000026$$aTeipel, Stefan$$b36$$udzne
000247521 7001_ $$0P:(DE-2719)2811317$$aWiltfang, Jens$$b37$$udzne
000247521 7001_ $$0P:(DE-2719)2810544$$aWolfsgruber, Steffen$$b38$$udzne
000247521 7001_ $$0P:(DE-2719)2000005$$aDüzel, Emrah$$b39$$udzne
000247521 7001_ $$0P:(DE-2719)2000032$$aJessen, Frank$$b40$$udzne
000247521 7001_ $$0P:(DE-2719)2000057$$aWagner, Michael$$b41$$eLast author$$udzne
000247521 7001_ $$agroup, DELCODE study$$b42$$eCollaboration Author
000247521 773__ $$0PERI:(DE-600)1498414-3$$a10.1016/j.neurobiolaging.2022.12.005$$gVol. 124, p. 18 - 28$$p18 - 28$$tNeurobiology of aging$$v124$$x0197-4580$$y2023
000247521 8564_ $$uhttps://www.sciencedirect.com/science/article/abs/pii/S0197458022002597
000247521 8564_ $$uhttps://pub.dzne.de/record/247521/files/DZNE-2023-00198_Restricted.pdf
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