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@ARTICLE{Liu:248108,
      author       = {Liu, Dan and Aziz, N. Ahmad and Pehlivan, Gökhan and
                      Breteler, Monique M B},
      title        = {{C}ardiovascular correlates of epigenetic aging across the
                      adult lifespan: a population-based study.},
      journal      = {GeroScience},
      volume       = {45},
      number       = {3},
      issn         = {2509-2715},
      address      = {[Cham]},
      publisher    = {Springer International Publishing},
      reportid     = {DZNE-2023-00212},
      pages        = {1605-1618},
      year         = {2023},
      note         = {CC BY},
      abstract     = {Individuals with a similar chronological age can exhibit
                      marked differences in cardiovascular risk profiles, but it
                      is unknown whether this variation is related to different
                      rates of biological aging. Therefore, we investigated the
                      relation between nine domains of cardiovascular function and
                      four epigenetic age acceleration estimators (i.e.,
                      AgeAccel.Horvath, AgeAccel.Hannum, AgeAccelPheno, and
                      AgeAccelGrim), derived from DNA methylation profiles. Among
                      4194 participants (mean age 54.2 years (range 30.0-95.0))
                      from the Rhineland Study, an ongoing population-based cohort
                      study in Bonn, Germany, epigenetic age acceleration
                      increased by 0.19-1.84 years per standard deviation (SD)
                      increase in cardiovascular risk across multiple domains,
                      including measures of kidney function, adiposity, and a
                      composite cardiovascular risk score. Measures of
                      inflammation and glucose homeostasis were associated with
                      AgeAccel.Hannum, AgeAccelPheno, and AgeAccelGrim, but not
                      with AgeAccel.Horvath. Moreover, effect sizes were larger
                      for AgeAccelPheno and AgeAccelGrim than for AgeAccel.Horvath
                      and AgeAccel.Hannum. Similarly, epigenetic age acceleration
                      increased by 0.15-0.81 years per SD increase in markers of
                      vascular function (blood pressure, arterial stiffness, and
                      hemodynamic measures), whereas better endothelial function
                      was only associated with lower AgeAccelGrim. Most effects on
                      epigenetic age acceleration were independent, which suggests
                      they independently contribute to different rates of
                      biological aging.},
      keywords     = {Humans / Aged / Aged, 80 and over / Longevity: genetics /
                      Cohort Studies / Epigenesis, Genetic: genetics / DNA
                      Methylation: genetics / Aging: genetics / Biological age
                      (Other) / Cardiovascular aging (Other) / Epigenetic age
                      acceleration (Other)},
      cin          = {AG Breteler / AG Aziz},
      ddc          = {610},
      cid          = {I:(DE-2719)1012001 / I:(DE-2719)5000071},
      pnm          = {354 - Disease Prevention and Healthy Aging (POF4-354)},
      pid          = {G:(DE-HGF)POF4-354},
      experiment   = {EXP:(DE-2719)Rhineland Study-20190321},
      typ          = {PUB:(DE-HGF)16},
      pmc          = {pmc:PMC10400487},
      pubmed       = {pmid:36752898},
      doi          = {10.1007/s11357-022-00714-0},
      url          = {https://pub.dzne.de/record/248108},
}