000255162 001__ 255162
000255162 005__ 20240118152416.0
000255162 037__ $$aDZNE-2023-00278
000255162 1001_ $$0P:(DE-2719)2811643$$aIslam, Rezaul$$b0$$udzne
000255162 245__ $$aDataset: Epigenetic gene-expression links heart failure to memory impairment [chipseq_tg_wt_3m]
000255162 260__ $$bGene Expression Omnibus$$c2020
000255162 3367_ $$2BibTeX$$aMISC
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000255162 520__ $$aIn current clinical practice care of diseased patients is often restricted to separated disciplines. However, such an organ-centered approach is not always suitable. For example, cognitive dysfunction is a severe burden in heart failure patients. Moreover, these patients have an increased risk for age-associated dementias. The underlying molecular mechanisms are presently unknown and thus corresponding therapeutic strategies to improve cognition in heart failure patients are missing. Using mice as model organisms we show that heart failure leads to specific changes in hippocampal gene-expression, a brain region intimately linked to cognition. These changes reflect increased cellular stress pathways which eventually lead to loss of neuronal euchromatin and reduced expression of a hippocampal gene cluster essential for cognition. Consequently, mice suffering from heart failure exhibit impaired memory function. These pathological changes are ameliorated via the administration of a drug that promotes neuronal euchromatin formation. Our study provides first insight to the molecular processes by which heart failure contributes to neuronal dysfunction and point to novel therapeutic avenues to treat cognitive defects in heart failure patients.
000255162 536__ $$0G:(DE-HGF)POF4-352$$a352 - Disease Mechanisms (POF4-352)$$cPOF4-352$$fPOF IV$$x0
000255162 7870_ $$0DZNE-2023-00244$$aIslam, Rezaul$$dGene Expression Omnibus, 2020$$iRelatedTo$$r$$tEpigenetic gene-expression links heart failure to memory impairment
000255162 8564_ $$uhttps://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE159436
000255162 909CO $$ooai:pub.dzne.de:255162$$pVDB
000255162 9101_ $$0I:(DE-588)1065079516$$6P:(DE-2719)2811643$$aDeutsches Zentrum für Neurodegenerative Erkrankungen$$b0$$kDZNE
000255162 9131_ $$0G:(DE-HGF)POF4-352$$1G:(DE-HGF)POF4-350$$2G:(DE-HGF)POF4-300$$3G:(DE-HGF)POF4$$4G:(DE-HGF)POF$$aDE-HGF$$bGesundheit$$lNeurodegenerative Diseases$$vDisease Mechanisms$$x0
000255162 9141_ $$y2020
000255162 9201_ $$0I:(DE-2719)1410002$$kAG Fischer$$lEpigenetics and Systems Medicine in Neurodegenerative Diseases$$x0
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