000255164 001__ 255164
000255164 005__ 20240118152733.0
000255164 037__ $$aDZNE-2023-00280
000255164 1001_ $$0P:(DE-2719)2811643$$aIslam, Rezaul$$b0$$udzne
000255164 245__ $$aDataset: Epigenetic gene-expression links heart failure to memory impairment [rnaseq_from_MI_experiment]
000255164 260__ $$bGene Expression Omnibus$$c2020
000255164 3367_ $$2BibTeX$$aMISC
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000255164 520__ $$aIn current clinical practice care of diseased patients is often restricted to separated disciplines. However, such an organ-centered approach is not always suitable. For example, cognitive dysfunction is a severe burden in heart failure patients. Moreover, these patients have an increased risk for age-associated dementias. The underlying molecular mechanisms are presently unknown and thus corresponding therapeutic strategies to improve cognition in heart failure patients are missing. Using mice as model organisms we show that heart failure leads to specific changes in hippocampal gene-expression, a brain region intimately linked to cognition. These changes reflect increased cellular stress pathways which eventually lead to loss of neuronal euchromatin and reduced expression of a hippocampal gene cluster essential for cognition. Consequently, mice suffering from heart failure exhibit impaired memory function. These pathological changes are ameliorated via the administration of a drug that promotes neuronal euchromatin formation. Our study provides first insight to the molecular processes by which heart failure contributes to neuronal dysfunction and point to novel therapeutic avenues to treat cognitive defects in heart failure patients.
000255164 536__ $$0G:(DE-HGF)POF4-352$$a352 - Disease Mechanisms (POF4-352)$$cPOF4-352$$fPOF IV$$x0
000255164 7870_ $$0DZNE-2023-00244$$aIslam, Rezaul$$dGene Expression Omnibus, 2020$$iRelatedTo$$r$$tEpigenetic gene-expression links heart failure to memory impairment
000255164 8564_ $$uhttps://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE159442
000255164 909CO $$ooai:pub.dzne.de:255164$$pVDB
000255164 9101_ $$0I:(DE-588)1065079516$$6P:(DE-2719)2811643$$aDeutsches Zentrum für Neurodegenerative Erkrankungen$$b0$$kDZNE
000255164 9131_ $$0G:(DE-HGF)POF4-352$$1G:(DE-HGF)POF4-350$$2G:(DE-HGF)POF4-300$$3G:(DE-HGF)POF4$$4G:(DE-HGF)POF$$aDE-HGF$$bGesundheit$$lNeurodegenerative Diseases$$vDisease Mechanisms$$x0
000255164 9141_ $$y2020
000255164 9201_ $$0I:(DE-2719)1410002$$kAG Fischer$$lEpigenetics and Systems Medicine in Neurodegenerative Diseases$$x0
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