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000256467 1001_ $$0P:(DE-2719)2812905$$aAntoniou, Anna$$b0$$eFirst author$$udzne
000256467 245__ $$aNeuronal extracellular vesicles and associated microRNAs induce circuit connectivity downstream BDNF.
000256467 260__ $$a[New York, NY]$$bElsevier$$c2023
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000256467 520__ $$aExtracellular vesicles (EVs) have emerged as mediators of cellular communication, in part via the delivery of associated microRNAs (miRNAs), small non-coding RNAs that regulate gene expression. We show that brain-derived neurotrophic factor (BDNF) mediates the sorting of miR-132-5p, miR-218-5p, and miR-690 in neuron-derived EVs. BDNF-induced EVs in turn increase excitatory synapse formation in recipient hippocampal neurons, which is dependent on the inter-neuronal delivery of these miRNAs. Transcriptomic analysis further indicates the differential expression of developmental and synaptogenesis-related genes by BDNF-induced EVs, many of which are predicted targets of miR-132-5p, miR-218-5p, and miR-690. Furthermore, BDNF-induced EVs up-regulate synaptic vesicle (SV) clustering in a transmissible manner, thereby increasing synaptic transmission and synchronous neuronal activity. As BDNF and EV-miRNAs miR-218 and miR-132 were previously implicated in neuropsychiatric disorders such as anxiety and depression, our results contribute to a better understanding of disorders characterized by aberrant neural circuit connectivity.
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000256467 650_7 $$2NLM Chemicals$$aMicroRNAs
000256467 650_7 $$2Other$$aBDNF
000256467 650_7 $$2Other$$aCP: Neuroscience
000256467 650_7 $$2Other$$aexosome
000256467 650_7 $$2Other$$aextracellular vesicle
000256467 650_7 $$2Other$$amicroRNA
000256467 650_7 $$2Other$$anetwork connectivity
000256467 650_7 $$2Other$$aneural circuit
000256467 650_7 $$2Other$$asynapse
000256467 650_7 $$2Other$$asynapse clustering
000256467 650_7 $$2NLM Chemicals$$aBrain-Derived Neurotrophic Factor
000256467 650_2 $$2MeSH$$aMicroRNAs: genetics
000256467 650_2 $$2MeSH$$aMicroRNAs: metabolism
000256467 650_2 $$2MeSH$$aBrain-Derived Neurotrophic Factor: metabolism
000256467 650_2 $$2MeSH$$aNeurons: metabolism
000256467 650_2 $$2MeSH$$aExtracellular Vesicles: metabolism
000256467 7001_ $$0P:(DE-2719)9001301$$aAuderset, Loic$$b1$$udzne
000256467 7001_ $$0P:(DE-2719)2812832$$aKaurani, Lalit$$b2$$udzne
000256467 7001_ $$0P:(DE-2719)9002055$$aSebastian, Eva$$b3$$udzne
000256467 7001_ $$0P:(DE-2719)9001925$$aZeng, Yuzhou$$b4$$udzne
000256467 7001_ $$aAllahham, Maria$$b5
000256467 7001_ $$aCases-Cunillera, Silvia$$b6
000256467 7001_ $$aSchoch, Susanne$$b7
000256467 7001_ $$0P:(DE-2719)9001219$$aGründemann, Jan$$b8$$udzne
000256467 7001_ $$0P:(DE-2719)2000047$$aFischer, Andre$$b9$$udzne
000256467 7001_ $$0P:(DE-2719)2812035$$aSchneider, Anja$$b10$$eLast author$$udzne
000256467 773__ $$0PERI:(DE-600)2649101-1$$a10.1016/j.celrep.2023.112063$$gVol. 42, no. 2, p. 112063 -$$n2$$p112063$$tCell reports$$v42$$x2211-1247$$y2023
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