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@ARTICLE{Antoniou:256467,
      author       = {Antoniou, Anna and Auderset, Loic and Kaurani, Lalit and
                      Sebastian, Eva and Zeng, Yuzhou and Allahham, Maria and
                      Cases-Cunillera, Silvia and Schoch, Susanne and Gründemann,
                      Jan and Fischer, Andre and Schneider, Anja},
      title        = {{N}euronal extracellular vesicles and associated
                      micro{RNA}s induce circuit connectivity downstream {BDNF}.},
      journal      = {Cell reports},
      volume       = {42},
      number       = {2},
      issn         = {2211-1247},
      address      = {[New York, NY]},
      publisher    = {Elsevier},
      reportid     = {DZNE-2023-00329},
      pages        = {112063},
      year         = {2023},
      note         = {CC BY},
      abstract     = {Extracellular vesicles (EVs) have emerged as mediators of
                      cellular communication, in part via the delivery of
                      associated microRNAs (miRNAs), small non-coding RNAs that
                      regulate gene expression. We show that brain-derived
                      neurotrophic factor (BDNF) mediates the sorting of
                      miR-132-5p, miR-218-5p, and miR-690 in neuron-derived EVs.
                      BDNF-induced EVs in turn increase excitatory synapse
                      formation in recipient hippocampal neurons, which is
                      dependent on the inter-neuronal delivery of these miRNAs.
                      Transcriptomic analysis further indicates the differential
                      expression of developmental and synaptogenesis-related genes
                      by BDNF-induced EVs, many of which are predicted targets of
                      miR-132-5p, miR-218-5p, and miR-690. Furthermore,
                      BDNF-induced EVs up-regulate synaptic vesicle (SV)
                      clustering in a transmissible manner, thereby increasing
                      synaptic transmission and synchronous neuronal activity. As
                      BDNF and EV-miRNAs miR-218 and miR-132 were previously
                      implicated in neuropsychiatric disorders such as anxiety and
                      depression, our results contribute to a better understanding
                      of disorders characterized by aberrant neural circuit
                      connectivity.},
      keywords     = {MicroRNAs: genetics / MicroRNAs: metabolism / Brain-Derived
                      Neurotrophic Factor: metabolism / Neurons: metabolism /
                      Extracellular Vesicles: metabolism / MicroRNAs (NLM
                      Chemicals) / BDNF (Other) / CP: Neuroscience (Other) /
                      exosome (Other) / extracellular vesicle (Other) / microRNA
                      (Other) / network connectivity (Other) / neural circuit
                      (Other) / synapse (Other) / synapse clustering (Other) /
                      Brain-Derived Neurotrophic Factor (NLM Chemicals)},
      cin          = {AG Schneider / AG Fischer / AG Gründemann / AG Bradke},
      ddc          = {610},
      cid          = {I:(DE-2719)1011305 / I:(DE-2719)1410002 /
                      I:(DE-2719)5000069 / I:(DE-2719)1013002},
      pnm          = {353 - Clinical and Health Care Research (POF4-353) / 352 -
                      Disease Mechanisms (POF4-352) / 351 - Brain Function
                      (POF4-351)},
      pid          = {G:(DE-HGF)POF4-353 / G:(DE-HGF)POF4-352 /
                      G:(DE-HGF)POF4-351},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:36753414},
      doi          = {10.1016/j.celrep.2023.112063},
      url          = {https://pub.dzne.de/record/256467},
}