Home > Publications Database > Neuronal extracellular vesicles and associated microRNAs induce circuit connectivity downstream BDNF. > print

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024 7 _ |a 10.1016/j.celrep.2023.112063
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024 7 _ |a 2211-1247
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024 7 _ |a 2639-1856
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037 _ _ |a DZNE-2023-00329
041 _ _ |a English
082 _ _ |a 610
100 1 _ |a Antoniou, Anna
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245 _ _ |a Neuronal extracellular vesicles and associated microRNAs induce circuit connectivity downstream BDNF.
260 _ _ |a [New York, NY]
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520 _ _ |a Extracellular vesicles (EVs) have emerged as mediators of cellular communication, in part via the delivery of associated microRNAs (miRNAs), small non-coding RNAs that regulate gene expression. We show that brain-derived neurotrophic factor (BDNF) mediates the sorting of miR-132-5p, miR-218-5p, and miR-690 in neuron-derived EVs. BDNF-induced EVs in turn increase excitatory synapse formation in recipient hippocampal neurons, which is dependent on the inter-neuronal delivery of these miRNAs. Transcriptomic analysis further indicates the differential expression of developmental and synaptogenesis-related genes by BDNF-induced EVs, many of which are predicted targets of miR-132-5p, miR-218-5p, and miR-690. Furthermore, BDNF-induced EVs up-regulate synaptic vesicle (SV) clustering in a transmissible manner, thereby increasing synaptic transmission and synchronous neuronal activity. As BDNF and EV-miRNAs miR-218 and miR-132 were previously implicated in neuropsychiatric disorders such as anxiety and depression, our results contribute to a better understanding of disorders characterized by aberrant neural circuit connectivity.
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650 _ 7 |a MicroRNAs
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650 _ 7 |a BDNF
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650 _ 7 |a CP: Neuroscience
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650 _ 7 |a exosome
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650 _ 7 |a extracellular vesicle
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650 _ 7 |a microRNA
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650 _ 7 |a network connectivity
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650 _ 7 |a neural circuit
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650 _ 7 |a synapse
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650 _ 7 |a synapse clustering
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650 _ 7 |a Brain-Derived Neurotrophic Factor
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650 _ 2 |a MicroRNAs: genetics
|2 MeSH
650 _ 2 |a MicroRNAs: metabolism
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650 _ 2 |a Brain-Derived Neurotrophic Factor: metabolism
|2 MeSH
650 _ 2 |a Neurons: metabolism
|2 MeSH
650 _ 2 |a Extracellular Vesicles: metabolism
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700 1 _ |a Auderset, Loic
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700 1 _ |a Kaurani, Lalit
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700 1 _ |a Sebastian, Eva
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700 1 _ |a Zeng, Yuzhou
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700 1 _ |a Allahham, Maria
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700 1 _ |a Cases-Cunillera, Silvia
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700 1 _ |a Schoch, Susanne
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700 1 _ |a Gründemann, Jan
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700 1 _ |a Fischer, Andre
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700 1 _ |a Schneider, Anja
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773 _ _ |a 10.1016/j.celrep.2023.112063
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