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@ARTICLE{Glykofridi:256473,
      author       = {Glykofridi, Pigi and Tziouri, Vassiliki-Eleni and
                      Xanthopoulos, Konstantinos and Vlachou, Maria-Eirini and
                      Silva-Correia, Susana and Fischer, Anna-Lisa and Thüne,
                      Katrin and Hatzidimitriou, Antonios and Zerr, Inga and
                      Schmitz, Matthias and Sklaviadis, Theodoros and
                      Hadjipavlou-Litina, Dimitra and Papagiannopoulou, Dionysia},
      title        = {{S}ynthesis, structural characterization and study of
                      antioxidant and anti-{P}r{PS}c properties of flavonoids and
                      their rhenium({I})-tricarbonyl complexes.},
      journal      = {Journal of biological inorganic chemistry},
      volume       = {28},
      number       = {2},
      issn         = {0949-8257},
      address      = {New York},
      publisher    = {Springer},
      reportid     = {DZNE-2023-00335},
      pages        = {235 - 247},
      year         = {2023},
      note         = {CC BY},
      abstract     = {This study aims at the synthesis and initial biological
                      evaluation of novel rhenium-tricarbonyl complexes of
                      3,3',4',5,7-pentahydroxyflavone (quercetin),
                      3,7,4΄-trihydroxyflavone (resokaempferol),
                      5,7-dihydroxyflavone (chrysin) and
                      4΄,5,7-trihydroxyflavonone (naringenin) as neuroprotective
                      and anti-PrP agents. Resokaempferol was synthesized from
                      2,2΄,4-trihydroxychalcone by H2O2/NaOH. The
                      rhenium-tricarbonyl complexes of the type
                      fac-[Re(CO)3(Fl)(sol)] were synthesized by reacting the
                      precursor fac-[Re(CO)3(sol)3]+ with an equimolar amount of
                      the flavonoids (Fl) quercetin, resokaempferol, chrysin and
                      naringenin and the solvent (sol) was methanol or water. The
                      respective Re-flavonoid complexes were purified by
                      semi-preparative HPLC and characterized by spectroscopic
                      methods. Furthermore, the structure of Re-chrysin was
                      elucidated by X-ray crystallography. Initial screening of
                      the neuroprotective properties of these compounds included
                      the in vitro assessment of the antioxidant properties by the
                      DPPH assay as well as the anti-lipid peroxidation of
                      linoleic acid in the presence of AAPH and their ability to
                      inhibit soybean lipoxygenase. From the above studies, it was
                      concluded that the complexes' properties are mainly
                      correlated with the structural characteristics and the
                      presence of the flavonoids. The flavonoids and their
                      respective Re-complexes were also tested in vitro for their
                      ability to inhibit the formation and aggregation of the
                      amyloid-like abnormal prion protein, PrPSc, by employing the
                      real-time quaking-induced conversion assay with recombinant
                      PrP seeded with cerebrospinal fluid from patients with
                      Creutzfeldt-Jakob disease. All the compounds blocked de novo
                      abnormal PrP formation and aggregation.},
      keywords     = {Flavonoids: chemistry / Humans / Antioxidants: pharmacology
                      / Rhenium: chemistry / Quercetin / Hydrogen Peroxide /
                      Crystallography, X-Ray / Flavonoids: pharmacology / PrPSc
                      Proteins: drug effects / PrPSc Proteins: metabolism /
                      Organometallic Compounds: chemistry / Organometallic
                      Compounds: pharmacology / Flavonoids (NLM Chemicals) /
                      Anti-oxidant (Other) / Flavonoids (Other) / Lipid
                      peroxidation (Other) / Lipoxygenase (Other) / Prion diseases
                      (Other) / Rhenium complexes (Other) / Antioxidants (NLM
                      Chemicals) / Rhenium (NLM Chemicals) / Quercetin (NLM
                      Chemicals) / Hydrogen Peroxide (NLM Chemicals) /
                      5-deoxykaempferol (NLM Chemicals) / chrysin (NLM Chemicals)
                      / naringenin (NLM Chemicals) / PrPSc Proteins (NLM
                      Chemicals) / Organometallic Compounds (NLM Chemicals)},
      cin          = {AG Zerr / Ext UMG Zerr / AG Fischer},
      cid          = {I:(DE-2719)1440011-1 / I:(DE-2719)5000037 /
                      I:(DE-2719)1410002},
      pnm          = {353 - Clinical and Health Care Research (POF4-353) / 352 -
                      Disease Mechanisms (POF4-352)},
      pid          = {G:(DE-HGF)POF4-353 / G:(DE-HGF)POF4-352},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:36695886},
      pmc          = {pmc:PMC9981504},
      doi          = {10.1007/s00775-022-01986-9},
      url          = {https://pub.dzne.de/record/256473},
}