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000256611 037__ $$aDZNE-2023-00363
000256611 041__ $$aEnglish
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000256611 1001_ $$aLi, Kaizhen$$b0
000256611 245__ $$aEndogenous but not sensory-driven activity controls migration, morphogenesis and survival of adult-born juxtaglomerular neurons in the mouse olfactory bulb.
000256611 260__ $$aCham (ZG)$$bSpringer International Publishing AG$$c2023
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000256611 520__ $$aThe development and survival of adult-born neurons are believed to be driven by sensory signaling. Here, in vivo analyses of motility, morphology and Ca2+ signaling, as well as transcriptome analyses of adult-born juxtaglomerular cells with reduced endogenous excitability (via cell-specific overexpression of either Kv1.2 or Kir2.1 K+ channels), revealed a pronounced impairment of migration, morphogenesis, survival, and functional integration of these cells into the mouse olfactory bulb, accompanied by a reduction in cytosolic Ca2+ fluctuations, phosphorylation of CREB and pCREB-mediated gene expression. Moreover, K+ channel overexpression strongly downregulated genes involved in neuronal migration, differentiation, and morphogenesis and upregulated apoptosis-related genes, thus locking adult-born cells in an immature and vulnerable state. Surprisingly, cells deprived of sensory-driven activity developed normally. Together, the data reveal signaling pathways connecting the endogenous intermittent neuronal activity/Ca2+ fluctuations as well as enhanced Kv1.2/Kir2.1 K+ channel function to migration, maturation, and survival of adult-born neurons.
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000256611 650_7 $$2Other$$aAdult neurogenesis
000256611 650_7 $$2Other$$aDifferentiation
000256611 650_7 $$2Other$$aEndogenous activity
000256611 650_7 $$2Other$$aMigration
000256611 650_7 $$2Other$$aNeuronal development
000256611 650_7 $$2Other$$aOlfactory bulb
000256611 650_7 $$2Other$$aPotassium channels
000256611 650_7 $$2Other$$aSpontaneous calcium transients
000256611 650_7 $$2Other$$aSurvival
000256611 650_7 $$2Other$$apCREB
000256611 650_2 $$2MeSH$$aMice
000256611 650_2 $$2MeSH$$aAnimals
000256611 650_2 $$2MeSH$$aOlfactory Bulb: metabolism
000256611 650_2 $$2MeSH$$aNeurons: metabolism
000256611 650_2 $$2MeSH$$aNeurogenesis: genetics
000256611 650_2 $$2MeSH$$aCell Differentiation
000256611 650_2 $$2MeSH$$aCell Movement
000256611 7001_ $$aFigarella, Katherine$$b1
000256611 7001_ $$aSu, Xin$$b2
000256611 7001_ $$aKovalchuk, Yury$$b3
000256611 7001_ $$aGorzolka, Jessika$$b4
000256611 7001_ $$0P:(DE-2719)2811021$$aNeher, Jonas J$$b5$$udzne
000256611 7001_ $$aMojtahedi, Nima$$b6
000256611 7001_ $$aCasadei, Nicolas$$b7
000256611 7001_ $$0P:(DE-HGF)0$$aHedrich, Ulrike B S$$b8
000256611 7001_ $$00000-0001-7400-5654$$aGaraschuk, Olga$$b9
000256611 773__ $$0PERI:(DE-600)1458497-9$$a10.1007/s00018-023-04753-4$$gVol. 80, no. 4, p. 98$$n4$$p98$$tCellular and molecular life sciences$$v80$$x1420-682X$$y2023
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