Home > Publications Database > Endogenous but not sensory-driven activity controls migration, morphogenesis and survival of adult-born juxtaglomerular neurons in the mouse olfactory bulb. > print

001     256611
005     20240625120743.0
024 7 _ |a 10.1007/s00018-023-04753-4
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024 7 _ |a 1420-9071
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037 _ _ |a DZNE-2023-00363
041 _ _ |a English
082 _ _ |a 610
100 1 _ |a Li, Kaizhen
|b 0
245 _ _ |a Endogenous but not sensory-driven activity controls migration, morphogenesis and survival of adult-born juxtaglomerular neurons in the mouse olfactory bulb.
260 _ _ |a Cham (ZG)
|c 2023
|b Springer International Publishing AG
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500 _ _ |a CC BY
520 _ _ |a The development and survival of adult-born neurons are believed to be driven by sensory signaling. Here, in vivo analyses of motility, morphology and Ca2+ signaling, as well as transcriptome analyses of adult-born juxtaglomerular cells with reduced endogenous excitability (via cell-specific overexpression of either Kv1.2 or Kir2.1 K+ channels), revealed a pronounced impairment of migration, morphogenesis, survival, and functional integration of these cells into the mouse olfactory bulb, accompanied by a reduction in cytosolic Ca2+ fluctuations, phosphorylation of CREB and pCREB-mediated gene expression. Moreover, K+ channel overexpression strongly downregulated genes involved in neuronal migration, differentiation, and morphogenesis and upregulated apoptosis-related genes, thus locking adult-born cells in an immature and vulnerable state. Surprisingly, cells deprived of sensory-driven activity developed normally. Together, the data reveal signaling pathways connecting the endogenous intermittent neuronal activity/Ca2+ fluctuations as well as enhanced Kv1.2/Kir2.1 K+ channel function to migration, maturation, and survival of adult-born neurons.
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650 _ 7 |a Adult neurogenesis
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650 _ 7 |a Differentiation
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650 _ 7 |a Endogenous activity
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650 _ 7 |a Migration
|2 Other
650 _ 7 |a Neuronal development
|2 Other
650 _ 7 |a Olfactory bulb
|2 Other
650 _ 7 |a Potassium channels
|2 Other
650 _ 7 |a Spontaneous calcium transients
|2 Other
650 _ 7 |a Survival
|2 Other
650 _ 7 |a pCREB
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650 _ 2 |a Mice
|2 MeSH
650 _ 2 |a Animals
|2 MeSH
650 _ 2 |a Olfactory Bulb: metabolism
|2 MeSH
650 _ 2 |a Neurons: metabolism
|2 MeSH
650 _ 2 |a Neurogenesis: genetics
|2 MeSH
650 _ 2 |a Cell Differentiation
|2 MeSH
650 _ 2 |a Cell Movement
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700 1 _ |a Figarella, Katherine
|b 1
700 1 _ |a Su, Xin
|b 2
700 1 _ |a Kovalchuk, Yury
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700 1 _ |a Gorzolka, Jessika
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700 1 _ |a Neher, Jonas J
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700 1 _ |a Mojtahedi, Nima
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700 1 _ |a Casadei, Nicolas
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700 1 _ |a Hedrich, Ulrike B S
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700 1 _ |a Garaschuk, Olga
|0 0000-0001-7400-5654
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773 _ _ |a 10.1007/s00018-023-04753-4
|g Vol. 80, no. 4, p. 98
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|t Cellular and molecular life sciences
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