000256634 001__ 256634
000256634 005__ 20240826165950.0
000256634 0247_ $$2doi$$a10.3233/JAD-220464
000256634 0247_ $$2pmid$$apmid:36806502
000256634 0247_ $$2ISSN$$a1387-2877
000256634 0247_ $$2ISSN$$a1875-8908
000256634 0247_ $$2altmetric$$aaltmetric:142887615
000256634 037__ $$aDZNE-2023-00370
000256634 041__ $$aEnglish
000256634 082__ $$a610
000256634 1001_ $$aErsoezlue, Ersin$$b0
000256634 245__ $$aA Residual Marker of Cognitive Reserve Is Associated with Resting-State Intrinsic Functional Connectivity Along the Alzheimer's Disease Continuum.
000256634 260__ $$aAmsterdam$$bIOS Press$$c2023
000256634 3367_ $$2DRIVER$$aarticle
000256634 3367_ $$2DataCite$$aOutput Types/Journal article
000256634 3367_ $$0PUB:(DE-HGF)16$$2PUB:(DE-HGF)$$aJournal Article$$bjournal$$mjournal$$s1710928327_2063
000256634 3367_ $$2BibTeX$$aARTICLE
000256634 3367_ $$2ORCID$$aJOURNAL_ARTICLE
000256634 3367_ $$00$$2EndNote$$aJournal Article
000256634 520__ $$aCognitive reserve (CR) explains inter-individual differences in the impact of the neurodegenerative burden on cognitive functioning. A residual model was proposed to estimate CR more accurately than previous measures. However, associations between residual CR markers (CRM) and functional connectivity (FC) remain unexplored.To explore the associations between the CRM and intrinsic network connectivity (INC) in resting-state networks along the neuropathological-continuum of Alzheimer's disease (ADN).Three hundred eighteen participants from the DELCODE cohort were stratified using cerebrospinal fluid biomarkers according to the A(myloid-β)/T(au)/N(eurodegeneration) classification. CRM was calculated utilizing residuals obtained from a multilinear regression model predicting cognition from markers of disease burden. Using an independent component analysis in resting-state fMRI data, we measured INC of resting-state networks, i.e., default mode network (DMN), frontoparietal network (FPN), salience network (SAL), and dorsal attention network. The associations of INC with a composite memory score and CRM and the associations of CRM with the seed-to-voxel functional connectivity of memory-related were tested in general linear models.CRM was positively associated with INC in the DMN in the entire cohort. The A+T+N+ group revealed an anti-correlation between the SAL and the DMN. Furthermore, CRM was positively associated with anti-correlation between memory-related regions in FPN and DMN in ADN and A+T/N+.Our results provide evidence that INC is associated with CRM in ADN defined as participants with amyloid pathology with or without cognitive symptoms, suggesting that the neural correlates of CR are mirrored in network FC in resting-state.
000256634 536__ $$0G:(DE-HGF)POF4-353$$a353 - Clinical and Health Care Research (POF4-353)$$cPOF4-353$$fPOF IV$$x0
000256634 536__ $$0G:(DE-HGF)POF4-352$$a352 - Disease Mechanisms (POF4-352)$$cPOF4-352$$fPOF IV$$x1
000256634 588__ $$aDataset connected to CrossRef, PubMed, , Journals: pub.dzne.de
000256634 650_7 $$2Other$$aAlzheimer’s disease
000256634 650_7 $$2Other$$aAlzheimer’s disease
000256634 650_7 $$2Other$$acognition
000256634 650_7 $$2Other$$acognitive reserve
000256634 650_7 $$2Other$$afunctional MRI
000256634 650_7 $$2Other$$aintrinsic network connectivity
000256634 650_7 $$2Other$$aresting-state functional connectivity
000256634 650_2 $$2MeSH$$aHumans
000256634 650_2 $$2MeSH$$aAlzheimer Disease: pathology
000256634 650_2 $$2MeSH$$aCognitive Reserve
000256634 650_2 $$2MeSH$$aCognition
000256634 650_2 $$2MeSH$$aNeural Pathways
000256634 650_2 $$2MeSH$$aNerve Net
000256634 650_2 $$2MeSH$$aMagnetic Resonance Imaging
000256634 650_2 $$2MeSH$$aBrain: diagnostic imaging
000256634 693__ $$0EXP:(DE-2719)DELCODE-20140101$$5EXP:(DE-2719)DELCODE-20140101$$eLongitudinal Cognitive Impairment and Dementia Study$$x0
000256634 7001_ $$0P:(DE-2719)2812234$$aPerneczky, Robert$$b1$$udzne
000256634 7001_ $$aTato, Maia$$b2
000256634 7001_ $$0P:(DE-2719)9000381$$aUtecht, Julia$$b3$$udzne
000256634 7001_ $$0P:(DE-HGF)0$$aKurz, Carolin$$b4
000256634 7001_ $$aHäckert, Jan$$b5
000256634 7001_ $$0P:(DE-2719)9001027$$aGuersel, Selim$$b6$$udzne
000256634 7001_ $$aBurow, Lena$$b7
000256634 7001_ $$aKoller, Gabriele$$b8
000256634 7001_ $$aStoecklein, Sophia$$b9
000256634 7001_ $$aKeeser, Daniel$$b10
000256634 7001_ $$aPapazov, Boris$$b11
000256634 7001_ $$aTotzke, Marie$$b12
000256634 7001_ $$0P:(DE-2719)9000476$$aBallarini, Tommaso$$b13$$udzne
000256634 7001_ $$0P:(DE-2719)2810593$$aBrosseron, Frederic$$b14$$udzne
000256634 7001_ $$0P:(DE-2719)2811351$$aBuerger, Katharina$$b15$$udzne
000256634 7001_ $$aDechent, Peter$$b16
000256634 7001_ $$0P:(DE-2719)2811611$$aDobisch, Laura$$b17$$udzne
000256634 7001_ $$0P:(DE-2719)9000543$$aEwers, Michael$$b18$$udzne
000256634 7001_ $$0P:(DE-2719)2811326$$aFliessbach, Klaus$$b19$$udzne
000256634 7001_ $$0P:(DE-2719)2811614$$aGlanz, Wenzel$$b20$$udzne
000256634 7001_ $$aHaynes, John Dylan$$b21
000256634 7001_ $$0P:(DE-2719)2000008$$aHeneka, Michael T$$b22$$udzne
000256634 7001_ $$0P:(DE-2719)9002557$$aJanowitz, Daniel$$b23$$udzne
000256634 7001_ $$0P:(DE-2719)2810394$$aKilimann, Ingo$$b24$$udzne
000256634 7001_ $$0P:(DE-2719)2812139$$aKleineidam, Luca$$b25$$udzne
000256634 7001_ $$0P:(DE-2719)2000055$$aLaske, Christoph$$b26$$udzne
000256634 7001_ $$aMaier, Franziska$$b27
000256634 7001_ $$0P:(DE-2719)9001516$$aMunk, Matthias H$$b28$$udzne
000256634 7001_ $$0P:(DE-2719)2811024$$aPeters, Oliver$$b29$$udzne
000256634 7001_ $$0P:(DE-2719)2811122$$aPriller, Josef$$b30$$udzne
000256634 7001_ $$0P:(DE-2719)2812825$$aRamirez, Alfredo$$b31$$udzne
000256634 7001_ $$0P:(DE-2719)2810395$$aRoeske, Sandra$$b32$$udzne
000256634 7001_ $$0P:(DE-2719)2812341$$aRoy, Nina$$b33$$udzne
000256634 7001_ $$aScheffler, Klaus$$b34
000256634 7001_ $$0P:(DE-2719)2812035$$aSchneider, Anja$$b35$$udzne
000256634 7001_ $$0P:(DE-2719)2814326$$aSchott, Björn H$$b36$$udzne
000256634 7001_ $$0P:(DE-2719)2811324$$aSpottke, Annika$$b37$$udzne
000256634 7001_ $$0P:(DE-2719)2812446$$aSpruth, Eike J$$b38$$udzne
000256634 7001_ $$0P:(DE-2719)2000026$$aTeipel, Stefan$$b39$$udzne
000256634 7001_ $$0P:(DE-2719)9001894$$aUnterfeld, Chantal$$b40$$udzne
000256634 7001_ $$0P:(DE-2719)2000057$$aWagner, Michael$$b41$$udzne
000256634 7001_ $$aWang, Xiao$$b42
000256634 7001_ $$0P:(DE-2719)2811317$$aWiltfang, Jens$$b43$$udzne
000256634 7001_ $$0P:(DE-2719)2810544$$aWolfsgruber, Steffen$$b44$$udzne
000256634 7001_ $$0P:(DE-2719)2812398$$aYakupov, Renat$$b45$$udzne
000256634 7001_ $$0P:(DE-2719)2000005$$aDuezel, Emrah$$b46$$udzne
000256634 7001_ $$0P:(DE-2719)2000032$$aJessen, Frank$$b47$$udzne
000256634 7001_ $$0P:(DE-2719)9001808$$aRauchmann, Boris-Stephan$$b48$$eLast author$$udzne
000256634 7001_ $$agroup, DELCODE study$$b49$$eCollaboration Author
000256634 773__ $$0PERI:(DE-600)2070772-1$$a10.3233/JAD-220464$$gp. 1 - 16$$n3$$p925 - 940$$tJournal of Alzheimer's disease$$v92$$x1387-2877$$y2023
000256634 8564_ $$uhttps://pub.dzne.de/record/256634/files/DZNE-2023-00370_Restricted.pdf
000256634 8564_ $$uhttps://pub.dzne.de/record/256634/files/DZNE-2023-00370_Restricted.pdf?subformat=pdfa$$xpdfa
000256634 909CO $$ooai:pub.dzne.de:256634$$pVDB
000256634 9101_ $$0I:(DE-588)1065079516$$6P:(DE-2719)2812234$$aDeutsches Zentrum für Neurodegenerative Erkrankungen$$b1$$kDZNE
000256634 9101_ $$0I:(DE-HGF)0$$6P:(DE-2719)9000381$$aExternal Institute$$b3$$kExtern
000256634 9101_ $$0I:(DE-HGF)0$$6P:(DE-2719)9001027$$aExternal Institute$$b6$$kExtern
000256634 9101_ $$0I:(DE-588)1065079516$$6P:(DE-2719)9000476$$aDeutsches Zentrum für Neurodegenerative Erkrankungen$$b13$$kDZNE
000256634 9101_ $$0I:(DE-588)1065079516$$6P:(DE-2719)2810593$$aDeutsches Zentrum für Neurodegenerative Erkrankungen$$b14$$kDZNE
000256634 9101_ $$0I:(DE-588)1065079516$$6P:(DE-2719)2811351$$aDeutsches Zentrum für Neurodegenerative Erkrankungen$$b15$$kDZNE
000256634 9101_ $$0I:(DE-588)1065079516$$6P:(DE-2719)2811611$$aDeutsches Zentrum für Neurodegenerative Erkrankungen$$b17$$kDZNE
000256634 9101_ $$0I:(DE-588)1065079516$$6P:(DE-2719)9000543$$aDeutsches Zentrum für Neurodegenerative Erkrankungen$$b18$$kDZNE
000256634 9101_ $$0I:(DE-588)1065079516$$6P:(DE-2719)2811326$$aDeutsches Zentrum für Neurodegenerative Erkrankungen$$b19$$kDZNE
000256634 9101_ $$0I:(DE-588)1065079516$$6P:(DE-2719)2811614$$aDeutsches Zentrum für Neurodegenerative Erkrankungen$$b20$$kDZNE
000256634 9101_ $$0I:(DE-588)1065079516$$6P:(DE-2719)2000008$$aDeutsches Zentrum für Neurodegenerative Erkrankungen$$b22$$kDZNE
000256634 9101_ $$0I:(DE-HGF)0$$6P:(DE-2719)9002557$$aExternal Institute$$b23$$kExtern
000256634 9101_ $$0I:(DE-588)1065079516$$6P:(DE-2719)2810394$$aDeutsches Zentrum für Neurodegenerative Erkrankungen$$b24$$kDZNE
000256634 9101_ $$0I:(DE-588)1065079516$$6P:(DE-2719)2812139$$aDeutsches Zentrum für Neurodegenerative Erkrankungen$$b25$$kDZNE
000256634 9101_ $$0I:(DE-588)1065079516$$6P:(DE-2719)2000055$$aDeutsches Zentrum für Neurodegenerative Erkrankungen$$b26$$kDZNE
000256634 9101_ $$0I:(DE-588)1065079516$$6P:(DE-2719)9001516$$aDeutsches Zentrum für Neurodegenerative Erkrankungen$$b28$$kDZNE
000256634 9101_ $$0I:(DE-588)1065079516$$6P:(DE-2719)2811024$$aDeutsches Zentrum für Neurodegenerative Erkrankungen$$b29$$kDZNE
000256634 9101_ $$0I:(DE-HGF)0$$6P:(DE-2719)2811122$$aExternal Institute$$b30$$kExtern
000256634 9101_ $$0I:(DE-588)1065079516$$6P:(DE-2719)2812825$$aDeutsches Zentrum für Neurodegenerative Erkrankungen$$b31$$kDZNE
000256634 9101_ $$0I:(DE-588)1065079516$$6P:(DE-2719)2810395$$aDeutsches Zentrum für Neurodegenerative Erkrankungen$$b32$$kDZNE
000256634 9101_ $$0I:(DE-588)1065079516$$6P:(DE-2719)2812341$$aDeutsches Zentrum für Neurodegenerative Erkrankungen$$b33$$kDZNE
000256634 9101_ $$0I:(DE-588)1065079516$$6P:(DE-2719)2812035$$aDeutsches Zentrum für Neurodegenerative Erkrankungen$$b35$$kDZNE
000256634 9101_ $$0I:(DE-588)1065079516$$6P:(DE-2719)2814326$$aDeutsches Zentrum für Neurodegenerative Erkrankungen$$b36$$kDZNE
000256634 9101_ $$0I:(DE-588)1065079516$$6P:(DE-2719)2811324$$aDeutsches Zentrum für Neurodegenerative Erkrankungen$$b37$$kDZNE
000256634 9101_ $$0I:(DE-588)1065079516$$6P:(DE-2719)2812446$$aDeutsches Zentrum für Neurodegenerative Erkrankungen$$b38$$kDZNE
000256634 9101_ $$0I:(DE-588)1065079516$$6P:(DE-2719)2000026$$aDeutsches Zentrum für Neurodegenerative Erkrankungen$$b39$$kDZNE
000256634 9101_ $$0I:(DE-HGF)0$$6P:(DE-2719)9001894$$aExternal Institute$$b40$$kExtern
000256634 9101_ $$0I:(DE-588)1065079516$$6P:(DE-2719)2000057$$aDeutsches Zentrum für Neurodegenerative Erkrankungen$$b41$$kDZNE
000256634 9101_ $$0I:(DE-588)1065079516$$6P:(DE-2719)2811317$$aDeutsches Zentrum für Neurodegenerative Erkrankungen$$b43$$kDZNE
000256634 9101_ $$0I:(DE-588)1065079516$$6P:(DE-2719)2810544$$aDeutsches Zentrum für Neurodegenerative Erkrankungen$$b44$$kDZNE
000256634 9101_ $$0I:(DE-588)1065079516$$6P:(DE-2719)2812398$$aDeutsches Zentrum für Neurodegenerative Erkrankungen$$b45$$kDZNE
000256634 9101_ $$0I:(DE-588)1065079516$$6P:(DE-2719)2000005$$aDeutsches Zentrum für Neurodegenerative Erkrankungen$$b46$$kDZNE
000256634 9101_ $$0I:(DE-588)1065079516$$6P:(DE-2719)2000032$$aDeutsches Zentrum für Neurodegenerative Erkrankungen$$b47$$kDZNE
000256634 9101_ $$0I:(DE-588)1065079516$$6P:(DE-2719)9001808$$aDeutsches Zentrum für Neurodegenerative Erkrankungen$$b48$$kDZNE
000256634 9131_ $$0G:(DE-HGF)POF4-353$$1G:(DE-HGF)POF4-350$$2G:(DE-HGF)POF4-300$$3G:(DE-HGF)POF4$$4G:(DE-HGF)POF$$aDE-HGF$$bGesundheit$$lNeurodegenerative Diseases$$vClinical and Health Care Research$$x0
000256634 9131_ $$0G:(DE-HGF)POF4-352$$1G:(DE-HGF)POF4-350$$2G:(DE-HGF)POF4-300$$3G:(DE-HGF)POF4$$4G:(DE-HGF)POF$$aDE-HGF$$bGesundheit$$lNeurodegenerative Diseases$$vDisease Mechanisms$$x1
000256634 9141_ $$y2023
000256634 915__ $$0StatID:(DE-HGF)1190$$2StatID$$aDBCoverage$$bBiological Abstracts$$d2022-11-18
000256634 915__ $$0StatID:(DE-HGF)0113$$2StatID$$aWoS$$bScience Citation Index Expanded$$d2022-11-18
000256634 915__ $$0StatID:(DE-HGF)0160$$2StatID$$aDBCoverage$$bEssential Science Indicators$$d2022-11-18
000256634 915__ $$0StatID:(DE-HGF)0100$$2StatID$$aJCR$$bJ ALZHEIMERS DIS : 2022$$d2023-08-25
000256634 915__ $$0StatID:(DE-HGF)0200$$2StatID$$aDBCoverage$$bSCOPUS$$d2023-08-25
000256634 915__ $$0StatID:(DE-HGF)0300$$2StatID$$aDBCoverage$$bMedline$$d2023-08-25
000256634 915__ $$0StatID:(DE-HGF)0600$$2StatID$$aDBCoverage$$bEbsco Academic Search$$d2023-08-25
000256634 915__ $$0StatID:(DE-HGF)0030$$2StatID$$aPeer Review$$bASC$$d2023-08-25
000256634 915__ $$0StatID:(DE-HGF)0199$$2StatID$$aDBCoverage$$bClarivate Analytics Master Journal List$$d2023-08-25
000256634 915__ $$0StatID:(DE-HGF)1050$$2StatID$$aDBCoverage$$bBIOSIS Previews$$d2023-08-25
000256634 915__ $$0StatID:(DE-HGF)0150$$2StatID$$aDBCoverage$$bWeb of Science Core Collection$$d2023-08-25
000256634 915__ $$0StatID:(DE-HGF)1030$$2StatID$$aDBCoverage$$bCurrent Contents - Life Sciences$$d2023-08-25
000256634 915__ $$0StatID:(DE-HGF)9900$$2StatID$$aIF < 5$$d2023-08-25
000256634 9201_ $$0I:(DE-2719)1110008$$kAG Simons$$lMolecular Neurobiology$$x0
000256634 9201_ $$0I:(DE-2719)5000022$$kAG Dichgans$$lVascular Cognitive Impairment & Post-Stroke Dementia$$x1
000256634 9201_ $$0I:(DE-2719)1011102$$kAG Jessen$$lClinical Alzheimer’s Disease Research$$x2
000256634 9201_ $$0I:(DE-2719)1410006$$kAG Wiltfang$$lMolecular biomarkers for predictive diagnostics of neurodegenerative diseases$$x3
000256634 9201_ $$0I:(DE-2719)1011201$$kAG Wagner$$lNeuropsychology$$x4
000256634 9201_ $$0I:(DE-2719)1011301$$kBiomarker$$lInterventional Trials and Biomarkers in Neurodegenerative Diseases$$x5
000256634 9201_ $$0I:(DE-2719)5000006$$kAG Düzel$$lClinical Neurophysiology and Memory$$x6
000256634 9201_ $$0I:(DE-2719)1011101$$kPatient Studies Bonn$$lPatient Studies Bonn$$x7
000256634 9201_ $$0I:(DE-2719)1510100$$kAG Teipel$$lClinical Dementia Research (Rostock /Greifswald)$$x8
000256634 9201_ $$0I:(DE-2719)1210000$$kAG Gasser$$lParkinson Genetics$$x9
000256634 9201_ $$0I:(DE-2719)1810002$$kAG Dirnagl$$lVascular Pathology$$x10
000256634 9201_ $$0I:(DE-2719)1011401$$kClinical Research Platform (CRP)$$lClinical Research Platform (CRP)$$x11
000256634 9201_ $$0I:(DE-2719)1011103$$kAG Spottke$$lClinical Research (Bonn)$$x12
000256634 9201_ $$0I:(DE-2719)1011305$$kAG Schneider$$lTranslational Dementia Research (Bonn)$$x13
000256634 9201_ $$0I:(DE-2719)1410002$$kAG Fischer$$lEpigenetics and Systems Medicine in Neurodegenerative Diseases$$x14
000256634 9201_ $$0I:(DE-2719)1811005$$kAG Endres$$lInterdisciplinary Dementia Research$$x15
000256634 9201_ $$0I:(DE-2719)5000034$$kDelcode$$lDelcode$$x16
000256634 980__ $$ajournal
000256634 980__ $$aVDB
000256634 980__ $$aI:(DE-2719)1110008
000256634 980__ $$aI:(DE-2719)5000022
000256634 980__ $$aI:(DE-2719)1011102
000256634 980__ $$aI:(DE-2719)1410006
000256634 980__ $$aI:(DE-2719)1011201
000256634 980__ $$aI:(DE-2719)1011301
000256634 980__ $$aI:(DE-2719)5000006
000256634 980__ $$aI:(DE-2719)1011101
000256634 980__ $$aI:(DE-2719)1510100
000256634 980__ $$aI:(DE-2719)1210000
000256634 980__ $$aI:(DE-2719)1810002
000256634 980__ $$aI:(DE-2719)1011401
000256634 980__ $$aI:(DE-2719)1011103
000256634 980__ $$aI:(DE-2719)1011305
000256634 980__ $$aI:(DE-2719)1410002
000256634 980__ $$aI:(DE-2719)1811005
000256634 980__ $$aI:(DE-2719)5000034
000256634 980__ $$aUNRESTRICTED