TY  - JOUR
AU  - Ersoezlue, Ersin
AU  - Perneczky, Robert
AU  - Tato, Maia
AU  - Utecht, Julia
AU  - Kurz, Carolin
AU  - Häckert, Jan
AU  - Guersel, Selim
AU  - Burow, Lena
AU  - Koller, Gabriele
AU  - Stoecklein, Sophia
AU  - Keeser, Daniel
AU  - Papazov, Boris
AU  - Totzke, Marie
AU  - Ballarini, Tommaso
AU  - Brosseron, Frederic
AU  - Buerger, Katharina
AU  - Dechent, Peter
AU  - Dobisch, Laura
AU  - Ewers, Michael
AU  - Fliessbach, Klaus
AU  - Glanz, Wenzel
AU  - Haynes, John Dylan
AU  - Heneka, Michael T
AU  - Janowitz, Daniel
AU  - Kilimann, Ingo
AU  - Kleineidam, Luca
AU  - Laske, Christoph
AU  - Maier, Franziska
AU  - Munk, Matthias H
AU  - Peters, Oliver
AU  - Priller, Josef
AU  - Ramirez, Alfredo
AU  - Roeske, Sandra
AU  - Roy, Nina
AU  - Scheffler, Klaus
AU  - Schneider, Anja
AU  - Schott, Björn H
AU  - Spottke, Annika
AU  - Spruth, Eike J
AU  - Teipel, Stefan
AU  - Unterfeld, Chantal
AU  - Wagner, Michael
AU  - Wang, Xiao
AU  - Wiltfang, Jens
AU  - Wolfsgruber, Steffen
AU  - Yakupov, Renat
AU  - Duezel, Emrah
AU  - Jessen, Frank
AU  - Rauchmann, Boris-Stephan
TI  - A Residual Marker of Cognitive Reserve Is Associated with Resting-State Intrinsic Functional Connectivity Along the Alzheimer's Disease Continuum.
JO  - Journal of Alzheimer's disease
VL  - 92
IS  - 3
SN  - 1387-2877
CY  - Amsterdam
PB  - IOS Press
M1  - DZNE-2023-00370
SP  - 925 - 940
PY  - 2023
AB  - Cognitive reserve (CR) explains inter-individual differences in the impact of the neurodegenerative burden on cognitive functioning. A residual model was proposed to estimate CR more accurately than previous measures. However, associations between residual CR markers (CRM) and functional connectivity (FC) remain unexplored.To explore the associations between the CRM and intrinsic network connectivity (INC) in resting-state networks along the neuropathological-continuum of Alzheimer's disease (ADN).Three hundred eighteen participants from the DELCODE cohort were stratified using cerebrospinal fluid biomarkers according to the A(myloid-β)/T(au)/N(eurodegeneration) classification. CRM was calculated utilizing residuals obtained from a multilinear regression model predicting cognition from markers of disease burden. Using an independent component analysis in resting-state fMRI data, we measured INC of resting-state networks, i.e., default mode network (DMN), frontoparietal network (FPN), salience network (SAL), and dorsal attention network. The associations of INC with a composite memory score and CRM and the associations of CRM with the seed-to-voxel functional connectivity of memory-related were tested in general linear models.CRM was positively associated with INC in the DMN in the entire cohort. The A+T+N+ group revealed an anti-correlation between the SAL and the DMN. Furthermore, CRM was positively associated with anti-correlation between memory-related regions in FPN and DMN in ADN and A+T/N+.Our results provide evidence that INC is associated with CRM in ADN defined as participants with amyloid pathology with or without cognitive symptoms, suggesting that the neural correlates of CR are mirrored in network FC in resting-state.
KW  - Humans
KW  - Alzheimer Disease: pathology
KW  - Cognitive Reserve
KW  - Cognition
KW  - Neural Pathways
KW  - Nerve Net
KW  - Magnetic Resonance Imaging
KW  - Brain: diagnostic imaging
KW  - Alzheimer’s disease (Other)
KW  - Alzheimer’s disease (Other)
KW  - cognition (Other)
KW  - cognitive reserve (Other)
KW  - functional MRI (Other)
KW  - intrinsic network connectivity (Other)
KW  - resting-state functional connectivity (Other)
LB  - PUB:(DE-HGF)16
C6  - pmid:36806502
DO  - DOI:10.3233/JAD-220464
UR  - https://pub.dzne.de/record/256634
ER  -