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@ARTICLE{Ersoezlue:256634,
      author       = {Ersoezlue, Ersin and Perneczky, Robert and Tato, Maia and
                      Utecht, Julia and Kurz, Carolin and Häckert, Jan and
                      Guersel, Selim and Burow, Lena and Koller, Gabriele and
                      Stoecklein, Sophia and Keeser, Daniel and Papazov, Boris and
                      Totzke, Marie and Ballarini, Tommaso and Brosseron, Frederic
                      and Buerger, Katharina and Dechent, Peter and Dobisch, Laura
                      and Ewers, Michael and Fliessbach, Klaus and Glanz, Wenzel
                      and Haynes, John Dylan and Heneka, Michael T and Janowitz,
                      Daniel and Kilimann, Ingo and Kleineidam, Luca and Laske,
                      Christoph and Maier, Franziska and Munk, Matthias H and
                      Peters, Oliver and Priller, Josef and Ramirez, Alfredo and
                      Roeske, Sandra and Roy, Nina and Scheffler, Klaus and
                      Schneider, Anja and Schott, Björn H and Spottke, Annika and
                      Spruth, Eike J and Teipel, Stefan and Unterfeld, Chantal and
                      Wagner, Michael and Wang, Xiao and Wiltfang, Jens and
                      Wolfsgruber, Steffen and Yakupov, Renat and Duezel, Emrah
                      and Jessen, Frank and Rauchmann, Boris-Stephan},
      collaboration = {group, DELCODE study},
      title        = {{A} {R}esidual {M}arker of {C}ognitive {R}eserve {I}s
                      {A}ssociated with {R}esting-{S}tate {I}ntrinsic {F}unctional
                      {C}onnectivity {A}long the {A}lzheimer's {D}isease
                      {C}ontinuum.},
      journal      = {Journal of Alzheimer's disease},
      volume       = {92},
      number       = {3},
      issn         = {1387-2877},
      address      = {Amsterdam},
      publisher    = {IOS Press},
      reportid     = {DZNE-2023-00370},
      pages        = {925 - 940},
      year         = {2023},
      abstract     = {Cognitive reserve (CR) explains inter-individual
                      differences in the impact of the neurodegenerative burden on
                      cognitive functioning. A residual model was proposed to
                      estimate CR more accurately than previous measures. However,
                      associations between residual CR markers (CRM) and
                      functional connectivity (FC) remain unexplored.To explore
                      the associations between the CRM and intrinsic network
                      connectivity (INC) in resting-state networks along the
                      neuropathological-continuum of Alzheimer's disease
                      (ADN).Three hundred eighteen participants from the DELCODE
                      cohort were stratified using cerebrospinal fluid biomarkers
                      according to the A(myloid-β)/T(au)/N(eurodegeneration)
                      classification. CRM was calculated utilizing residuals
                      obtained from a multilinear regression model predicting
                      cognition from markers of disease burden. Using an
                      independent component analysis in resting-state fMRI data,
                      we measured INC of resting-state networks, i.e., default
                      mode network (DMN), frontoparietal network (FPN), salience
                      network (SAL), and dorsal attention network. The
                      associations of INC with a composite memory score and CRM
                      and the associations of CRM with the seed-to-voxel
                      functional connectivity of memory-related were tested in
                      general linear models.CRM was positively associated with INC
                      in the DMN in the entire cohort. The A+T+N+ group revealed
                      an anti-correlation between the SAL and the DMN.
                      Furthermore, CRM was positively associated with
                      anti-correlation between memory-related regions in FPN and
                      DMN in ADN and A+T/N+.Our results provide evidence that INC
                      is associated with CRM in ADN defined as participants with
                      amyloid pathology with or without cognitive symptoms,
                      suggesting that the neural correlates of CR are mirrored in
                      network FC in resting-state.},
      keywords     = {Humans / Alzheimer Disease: pathology / Cognitive Reserve /
                      Cognition / Neural Pathways / Nerve Net / Magnetic Resonance
                      Imaging / Brain: diagnostic imaging / Alzheimer’s disease
                      (Other) / Alzheimer’s disease (Other) / cognition (Other)
                      / cognitive reserve (Other) / functional MRI (Other) /
                      intrinsic network connectivity (Other) / resting-state
                      functional connectivity (Other)},
      cin          = {AG Simons / AG Dichgans / AG Jessen / AG Wiltfang / AG
                      Wagner / Biomarker / AG Düzel / Patient Studies Bonn / AG
                      Teipel / AG Gasser / AG Dirnagl / Clinical Research Platform
                      (CRP) / AG Spottke / AG Schneider / AG Fischer / AG Endres /
                      Delcode},
      ddc          = {610},
      cid          = {I:(DE-2719)1110008 / I:(DE-2719)5000022 /
                      I:(DE-2719)1011102 / I:(DE-2719)1410006 / I:(DE-2719)1011201
                      / I:(DE-2719)1011301 / I:(DE-2719)5000006 /
                      I:(DE-2719)1011101 / I:(DE-2719)1510100 / I:(DE-2719)1210000
                      / I:(DE-2719)1810002 / I:(DE-2719)1011401 /
                      I:(DE-2719)1011103 / I:(DE-2719)1011305 / I:(DE-2719)1410002
                      / I:(DE-2719)1811005 / I:(DE-2719)5000034},
      pnm          = {353 - Clinical and Health Care Research (POF4-353) / 352 -
                      Disease Mechanisms (POF4-352)},
      pid          = {G:(DE-HGF)POF4-353 / G:(DE-HGF)POF4-352},
      experiment   = {EXP:(DE-2719)DELCODE-20140101},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:36806502},
      doi          = {10.3233/JAD-220464},
      url          = {https://pub.dzne.de/record/256634},
}