Home > Publications Database > A Residual Marker of Cognitive Reserve Is Associated with Resting-State Intrinsic Functional Connectivity Along the Alzheimer's Disease Continuum. > print

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024 7 _ |a 10.3233/JAD-220464
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024 7 _ |a pmid:36806502
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024 7 _ |a 1387-2877
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024 7 _ |a 1875-8908
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037 _ _ |a DZNE-2023-00370
041 _ _ |a English
082 _ _ |a 610
100 1 _ |a Ersoezlue, Ersin
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245 _ _ |a A Residual Marker of Cognitive Reserve Is Associated with Resting-State Intrinsic Functional Connectivity Along the Alzheimer's Disease Continuum.
260 _ _ |a Amsterdam
|c 2023
|b IOS Press
336 7 _ |a article
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336 7 _ |a ARTICLE
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520 _ _ |a Cognitive reserve (CR) explains inter-individual differences in the impact of the neurodegenerative burden on cognitive functioning. A residual model was proposed to estimate CR more accurately than previous measures. However, associations between residual CR markers (CRM) and functional connectivity (FC) remain unexplored.To explore the associations between the CRM and intrinsic network connectivity (INC) in resting-state networks along the neuropathological-continuum of Alzheimer's disease (ADN).Three hundred eighteen participants from the DELCODE cohort were stratified using cerebrospinal fluid biomarkers according to the A(myloid-β)/T(au)/N(eurodegeneration) classification. CRM was calculated utilizing residuals obtained from a multilinear regression model predicting cognition from markers of disease burden. Using an independent component analysis in resting-state fMRI data, we measured INC of resting-state networks, i.e., default mode network (DMN), frontoparietal network (FPN), salience network (SAL), and dorsal attention network. The associations of INC with a composite memory score and CRM and the associations of CRM with the seed-to-voxel functional connectivity of memory-related were tested in general linear models.CRM was positively associated with INC in the DMN in the entire cohort. The A+T+N+ group revealed an anti-correlation between the SAL and the DMN. Furthermore, CRM was positively associated with anti-correlation between memory-related regions in FPN and DMN in ADN and A+T/N+.Our results provide evidence that INC is associated with CRM in ADN defined as participants with amyloid pathology with or without cognitive symptoms, suggesting that the neural correlates of CR are mirrored in network FC in resting-state.
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650 _ 7 |a Alzheimer’s disease
|2 Other
650 _ 7 |a Alzheimer’s disease
|2 Other
650 _ 7 |a cognition
|2 Other
650 _ 7 |a cognitive reserve
|2 Other
650 _ 7 |a functional MRI
|2 Other
650 _ 7 |a intrinsic network connectivity
|2 Other
650 _ 7 |a resting-state functional connectivity
|2 Other
650 _ 2 |a Humans
|2 MeSH
650 _ 2 |a Alzheimer Disease: pathology
|2 MeSH
650 _ 2 |a Cognitive Reserve
|2 MeSH
650 _ 2 |a Cognition
|2 MeSH
650 _ 2 |a Neural Pathways
|2 MeSH
650 _ 2 |a Nerve Net
|2 MeSH
650 _ 2 |a Magnetic Resonance Imaging
|2 MeSH
650 _ 2 |a Brain: diagnostic imaging
|2 MeSH
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700 1 _ |a Spruth, Eike J
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773 _ _ |a 10.3233/JAD-220464
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