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@ARTICLE{BogadoLopes:257327,
      author       = {Bogado Lopes, Jadna and Malz, Monika and Senko, Anna N and
                      Zocher, Sara and Kempermann, Gerd},
      title        = {{L}oss of individualized behavioral trajectories in adult
                      neurogenesis-deficient cyclin {D}2 knockout mice.},
      journal      = {Hippocampus},
      volume       = {33},
      number       = {4},
      issn         = {1050-9631},
      address      = {New York, NY [u.a.]},
      publisher    = {Wiley},
      reportid     = {DZNE-2023-00396},
      pages        = {360 - 372},
      year         = {2023},
      note         = {CC BY-NC},
      abstract     = {There is still limited mechanistic insight into how the
                      interaction of individuals with their environment results in
                      the emergence of individuality in behavior and brain
                      structure. Nevertheless, the idea that personal activity
                      shapes the brain is implicit in strategies for healthy
                      cognitive aging as well as in the idea that individuality is
                      reflected in the brain's connectome. We have shown that even
                      isogenic mice kept in a shared enriched environment (ENR)
                      developed divergent and stable social and exploratory
                      trajectories. As these trajectories-measured as roaming
                      entropy (RE)-positively correlated with adult hippocampal
                      neurogenesis, we hypothesized that a feedback between
                      behavioral activity and adult hippocampal neurogenesis might
                      be a causal factor in brain individualization. We used
                      cyclin D2 knockout mice with constitutively extremely low
                      levels of adult hippocampal neurogenesis and their wild-type
                      littermates. We housed them for 3 months in a novel ENR
                      paradigm, consisting of 70 connected cages equipped with
                      radio frequency identification antennae for longitudinal
                      tracking. Cognitive performance was evaluated in the Morris
                      Water Maze task (MWM). With immunohistochemistry we
                      confirmed that adult neurogenesis correlated with RE in both
                      genotypes and that D2 knockout mice had the expected
                      impaired performance in the reversal phase of the MWM. But
                      whereas the wild-type animals developed stable exploratory
                      trajectories with increasing variance, correlating with
                      adult neurogenesis, this individualizing phenotype was
                      absent in D2 knockout mice. Here the behaviors started out
                      more random and revealed less habituation and low variance.
                      Together, these findings suggest that adult neurogenesis
                      contributes to experience-dependent brain
                      individualization.},
      keywords     = {Mice / Animals / Mice, Knockout / Cyclin D2: genetics /
                      Maze Learning / Hippocampus / Neurogenesis: genetics / Mice,
                      Inbred C57BL / hippocampus (Other) / home cage monitoring
                      (Other) / learning and memory (Other) / plasticity (Other) /
                      stem cell (Other) / Cyclin D2 (NLM Chemicals)},
      cin          = {AG Kempermann 1 / AG Toda},
      ddc          = {610},
      cid          = {I:(DE-2719)1710001 / I:(DE-2719)1710014},
      pnm          = {352 - Disease Mechanisms (POF4-352)},
      pid          = {G:(DE-HGF)POF4-352},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:36880417},
      doi          = {10.1002/hipo.23522},
      url          = {https://pub.dzne.de/record/257327},
}