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@ARTICLE{Schreiber:257330,
      author       = {Schreiber, Stefanie and Bernal Moya, Jose and Arndt,
                      Philipp and Schreiber, Frank and Müller, Patrick and
                      Morton, Lorena and Braun-Dullaeus, Rüdiger Christian and
                      Valdés-Hernández, Maria Del Carmen and Duarte, Roberto and
                      Wardlaw, Joanna Marguerite and Meuth, Sven Günther and
                      Mietzner, Grazia and Vielhaber, Stefan and Dunay, Ildiko
                      Rita and Dityatev, Alexander and Jandke, Solveig and
                      Mattern, Hendrik},
      title        = {{B}rain {V}ascular {H}ealth in {ALS} {I}s {M}ediated
                      through {M}otor {C}ortex {M}icrovascular {I}ntegrity.},
      journal      = {Cells},
      volume       = {12},
      number       = {6},
      issn         = {2073-4409},
      address      = {Basel},
      publisher    = {MDPI},
      reportid     = {DZNE-2023-00399},
      pages        = {957},
      year         = {2023},
      note         = {CC BY},
      abstract     = {Brain vascular health appears to be critical for preventing
                      the development of amyotrophic lateral sclerosis (ALS) and
                      slowing its progression. ALS patients often demonstrate
                      cardiovascular risk factors and commonly suffer from
                      cerebrovascular disease, with evidence of pathological
                      alterations in their small cerebral blood vessels. Impaired
                      vascular brain health has detrimental effects on motor
                      neurons: vascular endothelial growth factor levels are
                      lowered in ALS, which can compromise endothelial cell
                      formation and the integrity of the blood-brain barrier.
                      Increased turnover of neurovascular unit cells precedes
                      their senescence, which, together with pericyte alterations,
                      further fosters the failure of toxic metabolite removal. We
                      here provide a comprehensive overview of the pathogenesis of
                      impaired brain vascular health in ALS and how novel magnetic
                      resonance imaging techniques can aid its detection. In
                      particular, we discuss vascular patterns of blood supply to
                      the motor cortex with the number of branches from the
                      anterior and middle cerebral arteries acting as a novel
                      marker of resistance and resilience against downstream
                      effects of vascular risk and events in ALS. We outline how
                      certain interventions adapted to patient needs and
                      capabilities have the potential to mechanistically target
                      the brain microvasculature towards favorable motor cortex
                      blood supply patterns. Through this strategy, we aim to
                      guide novel approaches to ALS management and a better
                      understanding of ALS pathophysiology.},
      subtyp        = {Review Article},
      keywords     = {Humans / Amyotrophic Lateral Sclerosis: metabolism / Motor
                      Cortex: metabolism / Vascular Endothelial Growth Factor A:
                      metabolism / Motor Neurons: pathology / Blood-Brain Barrier:
                      pathology / amyotrophic lateral sclerosis (Other) /
                      exerkines (Other) / motor cortex (Other) / pericytes (Other)
                      / vascular supply (Other) / Vascular Endothelial Growth
                      Factor A (NLM Chemicals)},
      cin          = {AG Reymann / AG Schreiber / AG Düzel 3 / AG Müller / AG
                      Dityatev},
      ddc          = {570},
      cid          = {I:(DE-2719)1310005 / I:(DE-2719)1310010 /
                      I:(DE-2719)5000006 / I:(DE-2719)1310003 /
                      I:(DE-2719)1310007},
      pnm          = {352 - Disease Mechanisms (POF4-352) / 353 - Clinical and
                      Health Care Research (POF4-353) / 351 - Brain Function
                      (POF4-351)},
      pid          = {G:(DE-HGF)POF4-352 / G:(DE-HGF)POF4-353 /
                      G:(DE-HGF)POF4-351},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:36980297},
      pmc          = {pmc:PMC10047140},
      doi          = {10.3390/cells12060957},
      url          = {https://pub.dzne.de/record/257330},
}