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@ARTICLE{Brahimi:257339,
      author       = {Brahimi, Yacine and Knauer, Beate and Price, Alan Tobias
                      and Valero-Aracama, Maria Jesus and Reboreda, Antonio and
                      Sauvage, Magdalena and Yoshida, Motoharu},
      title        = {{P}ersistent {F}iring in {H}ippocampal {CA}1 {P}yramidal
                      {C}ells in {Y}oung and {A}ged {R}ats.},
      journal      = {eNeuro},
      volume       = {10},
      number       = {3},
      issn         = {2373-2822},
      address      = {Washington, DC},
      publisher    = {Soc.},
      reportid     = {DZNE-2023-00408},
      pages        = {ENEURO.0479-22.2023},
      year         = {2023},
      note         = {CC BY},
      abstract     = {Persistent neuronal firing is often observed in working
                      memory and temporal association tasks both in humans and
                      animals, and is believed to retain necessary information in
                      these tasks. We have reported that hippocampal CA1 pyramidal
                      cells are able to support persistent firing through
                      intrinsic mechanisms in the presence of cholinergic
                      agonists. However, it still remains largely unknown how
                      persistent firing is affected by the development of animals
                      and aging. Using in vitro patch-clamp recordings from CA1
                      pyramidal cells in rat brain slices, we first show that the
                      cellular excitability of these aged rats was significantly
                      lower than that of the young rats, responding with fewer
                      spikes to current injection. In addition, we found
                      age-dependent modulations of input resistance, membrane
                      capacitance, and spike width. However, persistent firing in
                      aged (approximately two-year-old) rats was as strong as that
                      in young animals, and the properties of persistent firing
                      were very similar among different age groups. In addition,
                      medium spike afterhyperpolarization potential (mAHP), was
                      not increased by aging and did not correlate with the
                      strength of persistent firing. Lastly, we estimated the
                      depolarization current induced by the cholinergic
                      activation. This current was proportional to the increased
                      membrane capacitance of the aged group and was inversely
                      correlated with their intrinsic excitability. These
                      observations indicate that robust persistent firing can be
                      maintained in aged rats despite reduced excitability,
                      because of the increased amount of cholinergically induced
                      positive current.},
      keywords     = {Humans / Rats / Animals / Child, Preschool / Pyramidal
                      Cells: physiology / Hippocampus: physiology / Action
                      Potentials: physiology / Neurons / Cholinergic Agents /
                      afterhyperpolarization (Other) / aged rats (Other) /
                      cholinergic agonist (Other) / depolarization current (Other)
                      / hippocampus (Other) / persistent firing (Other) /
                      Cholinergic Agents (NLM Chemicals)},
      cin          = {AG Yoshida},
      ddc          = {610},
      cid          = {I:(DE-2719)1310011},
      pnm          = {351 - Brain Function (POF4-351)},
      pid          = {G:(DE-HGF)POF4-351},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:36894320},
      pmc          = {pmc:PMC10062487},
      doi          = {10.1523/ENEURO.0479-22.2023},
      url          = {https://pub.dzne.de/record/257339},
}