TY  - JOUR
AU  - Teipel, Stefan
AU  - Grothe, Michel J
TI  - MRI-based basal forebrain atrophy and volumetric signatures associated with limbic TDP-43 compared to Alzheimer's disease pathology.
JO  - Neurobiology of disease
VL  - 180
SN  - 0969-9961
CY  - [Amsterdam]
PB  - Elsevier
M1  - DZNE-2023-00410
SP  - 106070
PY  - 2023
N1  - CC BY-NC-ND
AB  - It is not clear to which degree limbic TDP-43 pathology associates with a cholinergic deficit in the absence of Alzheimer's disease (AD) pathology.Replicate and extend recent evidence on cholinergic basal forebrain atrophy in limbic TDP-43 and evaluate MRI based patterns of atrophy as a surrogate marker for TDP-43.We studied ante-mortem MRI data of 11 autopsy cases with limbic TDP-43 pathology, 47 cases with AD pathology, and 26 mixed AD/TDP-43 cases from the ADNI autopsy sample, and 17 TDP-43, 170 AD, and 58 mixed AD/TDP-43 cases from the NACC autopsy sample. Group differences in basal forebrain and other brain volumes of interest were assessed using Bayesian ANCOVA. We assessed the diagnostic utility of MRI based patterns of brain atrophy using voxel-based receiver operating characteristics and random forest analyses.In the NACC sample, we found moderate evidence for the absence of a difference in basal forebrain volumes between AD, TDP-43, and mixed pathologies (Bayes factor(BF)10 = 0.324), and very strong evidence for lower hippocampus volume in TDP-43 and mixed cases compared with AD cases (BF10 = 156.1). The ratio of temporal to hippocampus volume reached an AUC of 75
KW  - Humans
KW  - Alzheimer Disease: pathology
KW  - Bayes Theorem
KW  - Basal Forebrain: diagnostic imaging
KW  - Basal Forebrain: pathology
KW  - Magnetic Resonance Imaging
KW  - Atrophy: pathology
KW  - DNA-Binding Proteins: metabolism
KW  - Cholinergic Agents
KW  - DNA-Binding Proteins (NLM Chemicals)
KW  - AD pathology (Other)
KW  - Autopsy (Other)
KW  - Cholinergic deficit (Other)
KW  - Imaging signature (Other)
KW  - Limbic TDP-43 (Other)
KW  - MRI (Other)
KW  - Cholinergic Agents (NLM Chemicals)
LB  - PUB:(DE-HGF)16
C6  - pmid:36898615
DO  - DOI:10.1016/j.nbd.2023.106070
UR  - https://pub.dzne.de/record/257341
ER  -