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@ARTICLE{Perosa:257557,
      author       = {Perosa, Valentina and Rotta, Johanna and Yakupov, Renat and
                      Kuijf, Hugo J and Schreiber, Frank and Oltmer, Jan T and
                      Mattern, Hendrik and Heinze, Hans-Jochen and Düzel, Emrah
                      and Schreiber, Stefanie},
      title        = {{I}mplications of quantitative susceptibility mapping at 7
                      {T}esla {MRI} for microbleeds detection in cerebral small
                      vessel disease.},
      journal      = {Frontiers in neurology},
      volume       = {14},
      issn         = {1664-2295},
      address      = {Lausanne},
      publisher    = {Frontiers Research Foundation},
      reportid     = {DZNE-2023-00437},
      pages        = {1112312},
      year         = {2023},
      abstract     = {Cerebral microbleeds (MBs) are a hallmark of cerebral small
                      vessel disease (CSVD) and can be found on T2*-weighted
                      sequences on MRI. Quantitative susceptibility mapping (QSM)
                      is a postprocessing method that also enables MBs
                      identification and furthermore allows to differentiate them
                      from calcifications.We explored the implications of using
                      QSM at submillimeter resolution for MBs detection in
                      CSVD.Both 3 and 7 Tesla (T) MRI were performed in elderly
                      participants without MBs and patients with CSVD. MBs were
                      quantified on T2*-weighted imaging and QSM. Differences in
                      the number of MBs were assessed, and subjects were
                      classified in CSVD subgroups or controls both on 3T
                      T2*-weighted imaging and 7T QSM.48 participants [mean age
                      (SD) 70.9 (8.8) years, $48\%$ females] were included: 31
                      were healthy controls, 6 probable cerebral amyloid
                      angiopathy (CAA), 9 mixed CSVD, and 2 were hypertensive
                      arteriopathy [HA] patients. After accounting for the higher
                      number of MBs detected at 7T QSM (Median = Mdn; Mdn7T-QSM =
                      2.5; Mdn3T-T2 = 0; z = 4.90; p < 0.001) and false positive
                      MBs $(6.1\%$ calcifications), most healthy controls
                      $(80.6\%)$ demonstrated at least one MB and more MBs were
                      discovered in the CSVD group.Our observations suggest that
                      QSM at submillimeter resolution improves the detection of
                      MBs in the elderly human brain. A higher prevalence of MBs
                      than so far known in healthy elderly was revealed.},
      keywords     = {7 Tesla MRI (Other) / cerebral amyloid angiopathy (CAA)
                      (Other) / cerebral small vessel disease (CSVD) (Other) /
                      hypertensive arteriopathy (HA) (Other) / microbleeds (Other)
                      / quantitative susceptibility mapping (QSM) (Other)},
      cin          = {AG Schreiber / AG Düzel 3 ; AG Düzel ; AG Düzel / AG
                      Reymann},
      ddc          = {610},
      cid          = {I:(DE-2719)1310010 / I:(DE-2719)5000006 /
                      I:(DE-2719)1310005},
      pnm          = {353 - Clinical and Health Care Research (POF4-353) / 352 -
                      Disease Mechanisms (POF4-352)},
      pid          = {G:(DE-HGF)POF4-353 / G:(DE-HGF)POF4-352},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:37006483},
      pmc          = {pmc:PMC10050564},
      doi          = {10.3389/fneur.2023.1112312},
      url          = {https://pub.dzne.de/record/257557},
}