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000257572 1001_ $$aLinnhoff, Stefanie$$b0
000257572 245__ $$aEffects of repetitive twice-weekly transcranial direct current stimulations on fatigue and fatigability in people with multiple sclerosis.
000257572 260__ $$a[London]$$bMacmillan Publishers Limited, part of Springer Nature$$c2023
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000257572 520__ $$aFatigue is associated with a dramatically decreased quality of life in people with multiple sclerosis (pwMS). It refers to a constant subjective feeling of exhaustion and performance decline, known as fatigability. However, inconsistency and heterogeneity in defining and assessing fatigue have led to limited advances in understanding and treating MS-associated fatigue. Transcranial direct current stimulation (tDCS) has emerged as a promising, non-pharmaceutical treatment strategy for subjective fatigue. However, whether repetitive tDCS also have long-term effects on time-on-task performance has not yet been investigated. This pseudorandomized, single-blinded, and sham-controlled study investigated tDCS effects on behavioral and electrophysiological parameters. 18 pwMS received eight twice-weekly 30 min stimulations over the left dorsolateral prefrontal cortex. Fatigability was operationalized as time-on-task-related changes in reaction time variability and P300 amplitude. Additionally, subjective trait and state fatigue ratings were assessed. The results revealed an overall decrease in subjective trait fatigue ratings that lasted at least four weeks after the stimulations. However, the ratings declined after both anodal and sham tDCS. No effects were found on subjective state fatigue and objective fatigability parameters. Linear Mixed Models and Bayesian Regression models likewise favored the absence of a tDCS effect on fatigability parameters. The results confirm the complex relationship between MS-associated fatigue and fatigability. Reliable and clinically relevant parameters need to be established to extend the potential of tDCS for treating fatigability. Furthermore, our results indicate that consecutive stimulations rather than twice-weekly stimulations should be the preferred stimulation scheme in future studies.
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000257572 650_2 $$2MeSH$$aFatigue: diagnosis
000257572 650_2 $$2MeSH$$aHumans
000257572 650_2 $$2MeSH$$aTranscranial Direct Current Stimulation: methods
000257572 650_2 $$2MeSH$$aMultiple Sclerosis: complications
000257572 650_2 $$2MeSH$$aQuality of Life
000257572 650_2 $$2MeSH$$aBayes Theorem
000257572 650_2 $$2MeSH$$aFatigue: complications
000257572 650_2 $$2MeSH$$aFatigue: etiology
000257572 650_2 $$2MeSH$$aFatigue: physiopathology
000257572 650_2 $$2MeSH$$aFatigue: therapy
000257572 650_2 $$2MeSH$$aMultiple Sclerosis: physiopathology
000257572 650_2 $$2MeSH$$aSingle-Blind Method
000257572 650_2 $$2MeSH$$aDorsolateral Prefrontal Cortex
000257572 650_2 $$2MeSH$$aTask Performance and Analysis
000257572 650_2 $$2MeSH$$aReaction Time
000257572 7001_ $$0P:(DE-2719)9001370$$aHaghikia, Aiden$$b1$$udzne
000257572 7001_ $$0P:(DE-2719)2301489$$aZähle, Tino$$b2$$udzne
000257572 773__ $$0PERI:(DE-600)2615211-3$$a10.1038/s41598-023-32779-y$$gVol. 13, no. 1, p. 5878$$n1$$p5878$$tScientific reports$$v13$$x2045-2322$$y2023
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