guest ::
| Home > Publications Database > Evolution of Clinical Outcome Measures and Biomarkers in Sporadic Adult-Onset Degenerative Ataxia. > print |
| Home > Publications Database > Evolution of Clinical Outcome Measures and Biomarkers in Sporadic Adult-Onset Degenerative Ataxia. > print |
| 001 | 257585 | ||
| 005 | 20240306115250.0 | ||
| 024 | 7 | _ | |a 10.1002/mds.29324 |2 doi |
| 024 | 7 | _ | |a pmid:36695111 |2 pmid |
| 024 | 7 | _ | |a 0885-3185 |2 ISSN |
| 024 | 7 | _ | |a 1531-8257 |2 ISSN |
| 037 | _ | _ | |a DZNE-2023-00461 |
| 041 | _ | _ | |a English |
| 082 | _ | _ | |a 610 |
| 100 | 1 | _ | |a Oender, Demet |0 P:(DE-2719)9000685 |b 0 |e First author |u dzne |
| 245 | _ | _ | |a Evolution of Clinical Outcome Measures and Biomarkers in Sporadic Adult-Onset Degenerative Ataxia. |
| 260 | _ | _ | |a New York, NY |c 2023 |b Wiley |
| 336 | 7 | _ | |a article |2 DRIVER |
| 336 | 7 | _ | |a Output Types/Journal article |2 DataCite |
| 336 | 7 | _ | |a Journal Article |b journal |m journal |0 PUB:(DE-HGF)16 |s 1709647082_29111 |2 PUB:(DE-HGF) |
| 336 | 7 | _ | |a ARTICLE |2 BibTeX |
| 336 | 7 | _ | |a JOURNAL_ARTICLE |2 ORCID |
| 336 | 7 | _ | |a Journal Article |0 0 |2 EndNote |
| 520 | _ | _ | |a Sporadic adult-onset ataxias without known genetic or acquired cause are subdivided into multiple system atrophy of cerebellar type (MSA-C) and sporadic adult-onset ataxia of unknown etiology (SAOA).To study the differential evolution of both conditions including plasma neurofilament light chain (NfL) levels and magnetic resonance imaging (MRI) markers.SPORTAX is a prospective registry of sporadic ataxia patients with an onset >40 years. Scale for the Assessment and Rating of Ataxia was the primary outcome measure. In subgroups, blood samples were taken and MRIs performed. Plasma NfL was measured via a single molecule assay. Regional brain volumes were automatically measured. To assess signal changes, we defined the pons and middle cerebellar peduncle abnormality score (PMAS). Using mixed-effects models, we analyzed changes on a time scale starting with ataxia onset.Of 404 patients without genetic diagnosis, 130 met criteria of probable MSA-C at baseline and 26 during follow-up suggesting clinical conversion to MSA-C. The remaining 248 were classified as SAOA. At baseline, NfL, cerebellar white matter (CWM) and pons volume, and PMAS separated MSA-C from SAOA. NfL decreased in MSA-C and did not change in SAOA. CWM and pons volume decreased faster, whereas PMAS increased faster in MSA-C. In MSA-C, pons volume had highest sensitivity to change, and PMAS was a predictor of faster progression. Fulfillment of possible MSA criteria, NfL and PMAS were risk factors, CWM and pons volume protective factors for conversion to MSA-C.This study provides detailed information on differential evolution and prognostic relevance of biomarkers in MSA-C and SAOA. © 2023 The Authors. Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society. |
| 536 | _ | _ | |a 353 - Clinical and Health Care Research (POF4-353) |0 G:(DE-HGF)POF4-353 |c POF4-353 |f POF IV |x 0 |
| 588 | _ | _ | |a Dataset connected to CrossRef, PubMed, , Journals: pub.dzne.de |
| 650 | _ | 7 | |a multiple system atrophy |2 Other |
| 650 | _ | 7 | |a natural history |2 Other |
| 650 | _ | 7 | |a neurofilament light chain |2 Other |
| 650 | _ | 7 | |a sporadic ataxia |2 Other |
| 650 | _ | 7 | |a volumetric MRI |2 Other |
| 650 | _ | 7 | |a Biomarkers |2 NLM Chemicals |
| 650 | _ | 2 | |a Humans |2 MeSH |
| 650 | _ | 2 | |a Adult |2 MeSH |
| 650 | _ | 2 | |a Cerebellar Ataxia: diagnosis |2 MeSH |
| 650 | _ | 2 | |a Ataxia: genetics |2 MeSH |
| 650 | _ | 2 | |a Cerebellum |2 MeSH |
| 650 | _ | 2 | |a Multiple System Atrophy: diagnosis |2 MeSH |
| 650 | _ | 2 | |a Biomarkers |2 MeSH |
| 700 | 1 | _ | |a Faber, Jennifer |0 P:(DE-2719)2811327 |b 1 |u dzne |
| 700 | 1 | _ | |a Wilke, Carlo |0 P:(DE-2719)2814101 |b 2 |
| 700 | 1 | _ | |a Schaprian, Tamara |0 P:(DE-2719)2812594 |b 3 |u dzne |
| 700 | 1 | _ | |a Lakghomi, Asadeh |b 4 |
| 700 | 1 | _ | |a Mengel, David |0 P:(DE-2719)9000375 |b 5 |u dzne |
| 700 | 1 | _ | |a Schöls, Ludger |0 P:(DE-2719)2810795 |b 6 |u dzne |
| 700 | 1 | _ | |a Traschuetz, Andreas |0 P:(DE-2719)9000792 |b 7 |u dzne |
| 700 | 1 | _ | |a Fleszar, Zofia |0 P:(DE-2719)9000074 |b 8 |u dzne |
| 700 | 1 | _ | |a Dufke, Claudia |b 9 |
| 700 | 1 | _ | |a Vielhaber, Stefan |0 P:(DE-2719)2000035 |b 10 |u dzne |
| 700 | 1 | _ | |a Machts, Judith |0 P:(DE-2719)2810317 |b 11 |u dzne |
| 700 | 1 | _ | |a Giordano, Ilaria |0 P:(DE-2719)2811662 |b 12 |u dzne |
| 700 | 1 | _ | |a Grobe-Einsler, Marcus |0 P:(DE-2719)9001510 |b 13 |
| 700 | 1 | _ | |a Klopstock, Thomas |0 P:(DE-2719)2810704 |b 14 |u dzne |
| 700 | 1 | _ | |a Stendel, Claudia |0 P:(DE-2719)2812141 |b 15 |u dzne |
| 700 | 1 | _ | |a Boesch, Sylvia |b 16 |
| 700 | 1 | _ | |a Nachbauer, Wolfgang |b 17 |
| 700 | 1 | _ | |a Timmann-Braun, Dagmar |b 18 |
| 700 | 1 | _ | |a Thieme, Andreas Gustafsson |b 19 |
| 700 | 1 | _ | |a Kamm, Christoph |0 P:(DE-2719)9000871 |b 20 |u dzne |
| 700 | 1 | _ | |a Dudesek, Ales |0 P:(DE-2719)2811832 |b 21 |u dzne |
| 700 | 1 | _ | |a Tallaksen, Chantal |b 22 |
| 700 | 1 | _ | |a Wedding, Iselin |b 23 |
| 700 | 1 | _ | |a Filla, Alessandro |b 24 |
| 700 | 1 | _ | |a Schmid, Matthias |0 P:(DE-2719)2811245 |b 25 |u dzne |
| 700 | 1 | _ | |a Synofzik, Matthis |0 P:(DE-2719)2811275 |b 26 |
| 700 | 1 | _ | |a Klockgether, Thomas |0 P:(DE-2719)2810314 |b 27 |e Last author |
| 773 | _ | _ | |a 10.1002/mds.29324 |g Vol. 38, no. 4, p. 654 - 664 |0 PERI:(DE-600)2041249-6 |n 4 |p 654 - 664 |t Movement disorders |v 38 |y 2023 |x 0885-3185 |
| 856 | 4 | _ | |u https://pub.dzne.de/record/257585/files/DZNE-2023-00461%20SUP.doc |
| 856 | 4 | _ | |u https://pub.dzne.de/record/257585/files/DZNE-2023-00461%20SUP.docx |
| 856 | 4 | _ | |u https://pub.dzne.de/record/257585/files/DZNE-2023-00461%20SUP.odt |
| 856 | 4 | _ | |u https://pub.dzne.de/record/257585/files/DZNE-2023-00461%20SUP.pdf |
| 856 | 4 | _ | |u https://pub.dzne.de/record/257585/files/DZNE-2023-00461.pdf |y OpenAccess |
| 856 | 4 | _ | |u https://pub.dzne.de/record/257585/files/DZNE-2023-00461.pdf?subformat=pdfa |x pdfa |y OpenAccess |
| 909 | C | O | |o oai:pub.dzne.de:257585 |p openaire |p open_access |p VDB |p driver |p dnbdelivery |
| 910 | 1 | _ | |a Deutsches Zentrum für Neurodegenerative Erkrankungen |0 I:(DE-588)1065079516 |k DZNE |b 0 |6 P:(DE-2719)9000685 |
| 910 | 1 | _ | |a Deutsches Zentrum für Neurodegenerative Erkrankungen |0 I:(DE-588)1065079516 |k DZNE |b 1 |6 P:(DE-2719)2811327 |
| 910 | 1 | _ | |a External Institute |0 I:(DE-HGF)0 |k Extern |b 2 |6 P:(DE-2719)2814101 |
| 910 | 1 | _ | |a Deutsches Zentrum für Neurodegenerative Erkrankungen |0 I:(DE-588)1065079516 |k DZNE |b 3 |6 P:(DE-2719)2812594 |
| 910 | 1 | _ | |a External Institute |0 I:(DE-HGF)0 |k Extern |b 5 |6 P:(DE-2719)9000375 |
| 910 | 1 | _ | |a Deutsches Zentrum für Neurodegenerative Erkrankungen |0 I:(DE-588)1065079516 |k DZNE |b 6 |6 P:(DE-2719)2810795 |
| 910 | 1 | _ | |a Deutsches Zentrum für Neurodegenerative Erkrankungen |0 I:(DE-588)1065079516 |k DZNE |b 7 |6 P:(DE-2719)9000792 |
| 910 | 1 | _ | |a Deutsches Zentrum für Neurodegenerative Erkrankungen |0 I:(DE-588)1065079516 |k DZNE |b 8 |6 P:(DE-2719)9000074 |
| 910 | 1 | _ | |a Deutsches Zentrum für Neurodegenerative Erkrankungen |0 I:(DE-588)1065079516 |k DZNE |b 10 |6 P:(DE-2719)2000035 |
| 910 | 1 | _ | |a Deutsches Zentrum für Neurodegenerative Erkrankungen |0 I:(DE-588)1065079516 |k DZNE |b 11 |6 P:(DE-2719)2810317 |
| 910 | 1 | _ | |a Deutsches Zentrum für Neurodegenerative Erkrankungen |0 I:(DE-588)1065079516 |k DZNE |b 12 |6 P:(DE-2719)2811662 |
| 910 | 1 | _ | |a Deutsches Zentrum für Neurodegenerative Erkrankungen |0 I:(DE-588)1065079516 |k DZNE |b 13 |6 P:(DE-2719)9001510 |
| 910 | 1 | _ | |a Deutsches Zentrum für Neurodegenerative Erkrankungen |0 I:(DE-588)1065079516 |k DZNE |b 14 |6 P:(DE-2719)2810704 |
| 910 | 1 | _ | |a Deutsches Zentrum für Neurodegenerative Erkrankungen |0 I:(DE-588)1065079516 |k DZNE |b 15 |6 P:(DE-2719)2812141 |
| 910 | 1 | _ | |a Deutsches Zentrum für Neurodegenerative Erkrankungen |0 I:(DE-588)1065079516 |k DZNE |b 20 |6 P:(DE-2719)9000871 |
| 910 | 1 | _ | |a Deutsches Zentrum für Neurodegenerative Erkrankungen |0 I:(DE-588)1065079516 |k DZNE |b 21 |6 P:(DE-2719)2811832 |
| 910 | 1 | _ | |a Deutsches Zentrum für Neurodegenerative Erkrankungen |0 I:(DE-588)1065079516 |k DZNE |b 25 |6 P:(DE-2719)2811245 |
| 910 | 1 | _ | |a Deutsches Zentrum für Neurodegenerative Erkrankungen |0 I:(DE-588)1065079516 |k DZNE |b 26 |6 P:(DE-2719)2811275 |
| 910 | 1 | _ | |a Deutsches Zentrum für Neurodegenerative Erkrankungen |0 I:(DE-588)1065079516 |k DZNE |b 27 |6 P:(DE-2719)2810314 |
| 913 | 1 | _ | |a DE-HGF |b Gesundheit |l Neurodegenerative Diseases |1 G:(DE-HGF)POF4-350 |0 G:(DE-HGF)POF4-353 |3 G:(DE-HGF)POF4 |2 G:(DE-HGF)POF4-300 |4 G:(DE-HGF)POF |v Clinical and Health Care Research |x 0 |
| 914 | 1 | _ | |y 2023 |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)0160 |2 StatID |b Essential Science Indicators |d 2022-11-11 |
| 915 | _ | _ | |a Creative Commons Attribution-NonCommercial-NoDerivs CC BY-NC-ND 4.0 |0 LIC:(DE-HGF)CCBYNCND4 |2 HGFVOC |
| 915 | _ | _ | |a DEAL Wiley |0 StatID:(DE-HGF)3001 |2 StatID |d 2022-11-11 |w ger |
| 915 | _ | _ | |a WoS |0 StatID:(DE-HGF)0113 |2 StatID |b Science Citation Index Expanded |d 2022-11-11 |
| 915 | _ | _ | |a OpenAccess |0 StatID:(DE-HGF)0510 |2 StatID |
| 915 | _ | _ | |a Nationallizenz |0 StatID:(DE-HGF)0420 |2 StatID |d 2023-10-24 |w ger |
| 915 | _ | _ | |a JCR |0 StatID:(DE-HGF)0100 |2 StatID |b MOVEMENT DISORD : 2022 |d 2023-10-24 |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)0200 |2 StatID |b SCOPUS |d 2023-10-24 |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)0300 |2 StatID |b Medline |d 2023-10-24 |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)0600 |2 StatID |b Ebsco Academic Search |d 2023-10-24 |
| 915 | _ | _ | |a Peer Review |0 StatID:(DE-HGF)0030 |2 StatID |b ASC |d 2023-10-24 |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)0199 |2 StatID |b Clarivate Analytics Master Journal List |d 2023-10-24 |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)0150 |2 StatID |b Web of Science Core Collection |d 2023-10-24 |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)1030 |2 StatID |b Current Contents - Life Sciences |d 2023-10-24 |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)1110 |2 StatID |b Current Contents - Clinical Medicine |d 2023-10-24 |
| 915 | _ | _ | |a IF >= 5 |0 StatID:(DE-HGF)9905 |2 StatID |b MOVEMENT DISORD : 2022 |d 2023-10-24 |
| 920 | 1 | _ | |0 I:(DE-2719)1011001 |k AG Klockgether |l Patient Studies |x 0 |
| 920 | 1 | _ | |0 I:(DE-2719)1011401 |k Clinical Research Platform (CRP) |l Clinical Research Platform (CRP) |x 1 |
| 920 | 1 | _ | |0 I:(DE-2719)1011101 |k Patient Studies Bonn |l Patient Studies Bonn |x 2 |
| 920 | 1 | _ | |0 I:(DE-2719)1210000 |k AG Gasser |l Parkinson Genetics |x 3 |
| 920 | 1 | _ | |0 I:(DE-2719)1013028 |k AG Schmid Bonn |l Mathematics, statistics and informatics methods for support of population studies and clinical research |x 4 |
| 920 | 1 | _ | |0 I:(DE-2719)5000005 |k AG Schöls |l Clinical Neurogenetics |x 5 |
| 920 | 1 | _ | |0 I:(DE-2719)1111015 |k Clinical Research (Munich) |l Clinical Research (Munich) |x 6 |
| 920 | 1 | _ | |0 I:(DE-2719)1110002 |k AG Höglinger 1 |l Translational Neurodegeneration |x 7 |
| 920 | 1 | _ | |0 I:(DE-2719)5000006 |k AG Düzel |l Clinical Neurophysiology and Memory |x 8 |
| 980 | _ | _ | |a journal |
| 980 | _ | _ | |a VDB |
| 980 | _ | _ | |a I:(DE-2719)1011001 |
| 980 | _ | _ | |a I:(DE-2719)1011401 |
| 980 | _ | _ | |a I:(DE-2719)1011101 |
| 980 | _ | _ | |a I:(DE-2719)1210000 |
| 980 | _ | _ | |a I:(DE-2719)1013028 |
| 980 | _ | _ | |a I:(DE-2719)5000005 |
| 980 | _ | _ | |a I:(DE-2719)1111015 |
| 980 | _ | _ | |a I:(DE-2719)1110002 |
| 980 | _ | _ | |a I:(DE-2719)5000006 |
| 980 | _ | _ | |a UNRESTRICTED |
| 980 | 1 | _ | |a FullTexts |
| Library | Collection | CLSMajor | CLSMinor | Language | Author |
|---|