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000257587 1001_ $$00000-0002-5846-1104$$aSugier, Pierre-Emmanuel$$b0
000257587 245__ $$aInvestigation of Shared Genetic Risk Factors Between Parkinson's Disease and Cancers.
000257587 260__ $$aNew York, NY$$bWiley$$c2023
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000257587 520__ $$aEpidemiological studies that examined the association between Parkinson's disease (PD) and cancers led to inconsistent results, but they face a number of methodological difficulties.We used results from genome-wide association studies (GWASs) to study the genetic correlation between PD and different cancers to identify common genetic risk factors.We used individual data for participants of European ancestry from the Courage-PD (Comprehensive Unbiased Risk Factor Assessment for Genetics and Environment in Parkinson's Disease; PD, N = 16,519) and EPITHYR (differentiated thyroid cancer, N = 3527) consortia and summary statistics of GWASs from iPDGC (International Parkinson Disease Genomics Consortium; PD, N = 482,730), Melanoma Meta-Analysis Consortium (MMAC), Breast Cancer Association Consortium (breast cancer), the Prostate Cancer Association Group to Investigate Cancer Associated Alterations in the Genome (prostate cancer), International Lung Cancer Consortium (lung cancer), and Ovarian Cancer Association Consortium (ovarian cancer) (N comprised between 36,017 and 228,951 for cancer GWASs). We estimated the genetic correlation between PD and cancers using linkage disequilibrium score regression. We studied the association between PD and polymorphisms associated with cancers, and vice versa, using cross-phenotypes polygenic risk score (PRS) analyses.We confirmed a previously reported positive genetic correlation of PD with melanoma (Gcorr = 0.16 [0.04; 0.28]) and reported an additional significant positive correlation of PD with prostate cancer (Gcorr = 0.11 [0.03; 0.19]). There was a significant inverse association between the PRS for ovarian cancer and PD (odds ratio [OR] = 0.89 [0.84; 0.94]). Conversely, the PRS of PD was positively associated with breast cancer (OR = 1.08 [1.06; 1.10]) and inversely associated with ovarian cancer (OR = 0.95 [0.91; 0.99]). The association between PD and ovarian cancer was mostly driven by rs183211 located in an intron of the NSF gene (17q21.31).We show evidence in favor of a contribution of pleiotropic genes to the association between PD and specific cancers. © 2023 The Authors. Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society. This article has been contributed to by U.S. Government employees and their work is in the public domain in the USA.
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000257587 650_7 $$2Other$$aParkinson's disease
000257587 650_7 $$2Other$$acancer
000257587 650_7 $$2Other$$agenetic correlation
000257587 650_7 $$2Other$$apleiotropy
000257587 650_7 $$2Other$$apolygenic risk score
000257587 650_2 $$2MeSH$$aHumans
000257587 650_2 $$2MeSH$$aMale
000257587 650_2 $$2MeSH$$aFemale
000257587 650_2 $$2MeSH$$aParkinson Disease: epidemiology
000257587 650_2 $$2MeSH$$aParkinson Disease: genetics
000257587 650_2 $$2MeSH$$aGenome-Wide Association Study
000257587 650_2 $$2MeSH$$aGenetic Predisposition to Disease: genetics
000257587 650_2 $$2MeSH$$aPolymorphism, Single Nucleotide: genetics
000257587 650_2 $$2MeSH$$aMelanoma: epidemiology
000257587 650_2 $$2MeSH$$aMelanoma: genetics
000257587 650_2 $$2MeSH$$aProstatic Neoplasms
000257587 650_2 $$2MeSH$$aOvarian Neoplasms
000257587 650_2 $$2MeSH$$aRisk Factors
000257587 650_2 $$2MeSH$$aLung Neoplasms
000257587 7001_ $$aLucotte, Elise A$$b1
000257587 7001_ $$00000-0001-6408-0351$$aDomenighetti, Cloé$$b2
000257587 7001_ $$aLaw, Matthew H$$b3
000257587 7001_ $$aIles, Mark M$$b4
000257587 7001_ $$aBrown, Kevin$$b5
000257587 7001_ $$aAmos, Christopher$$b6
000257587 7001_ $$aMcKay, James D$$b7
000257587 7001_ $$aHung, Rayjean J$$b8
000257587 7001_ $$aKarimi, Mojgan$$b9
000257587 7001_ $$aBacq-Daian, Delphine$$b10
000257587 7001_ $$aBoland-Augé, Anne$$b11
000257587 7001_ $$aOlaso, Robert$$b12
000257587 7001_ $$aDeleuze, Jean-François$$b13
000257587 7001_ $$aLesueur, Fabienne$$b14
000257587 7001_ $$aOstroumova, Evgenia$$b15
000257587 7001_ $$aKesminiene, Ausrele$$b16
000257587 7001_ $$ade Vathaire, Florent$$b17
000257587 7001_ $$aGuénel, Pascal$$b18
000257587 7001_ $$aconsortium, EPITHYR$$b19$$eCollaboration Author
000257587 7001_ $$aSreelatha, Ashwin Ashok Kumar$$b20
000257587 7001_ $$0P:(DE-2719)9000366$$aSchulte, Claudia$$b21$$udzne
000257587 7001_ $$00000-0003-2615-4916$$aGrover, Sandeep$$b22
000257587 7001_ $$00000-0001-8698-3770$$aMay, Patrick$$b23
000257587 7001_ $$00000-0002-1368-9623$$aBobbili, Dheeraj R$$b24
000257587 7001_ $$aRadivojkov-Blagojevic, Milena$$b25
000257587 7001_ $$aLichtner, Peter$$b26
000257587 7001_ $$aSingleton, Andrew B$$b27
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000257587 7001_ $$aEdsall, Connor$$b29
000257587 7001_ $$aMellick, George D$$b30
000257587 7001_ $$00000-0002-1668-5177$$aZimprich, Alexander$$b31
000257587 7001_ $$aPirker, Walter$$b32
000257587 7001_ $$aRogaeva, Ekaterina$$b33
000257587 7001_ $$00000-0003-1229-3667$$aLang, Anthony E$$b34
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000257587 7001_ $$aTaba, Pille$$b36
000257587 7001_ $$aLesage, Suzanne$$b37
000257587 7001_ $$aBrice, Alexis$$b38
000257587 7001_ $$00000-0001-7325-0199$$aCorvol, Jean-Christophe$$b39
000257587 7001_ $$aChartier-Harlin, Marie-Christine$$b40
000257587 7001_ $$00000-0002-5947-0432$$aMutez, Eugénie$$b41
000257587 7001_ $$0P:(DE-2719)2811916$$aBrockmann, Kathrin$$b42
000257587 7001_ $$00000-0003-2152-9926$$aDeutschländer, Angela B$$b43
000257587 7001_ $$aHadjigeorgiou, Georges M$$b44
000257587 7001_ $$aDardiotis, Efthimios$$b45
000257587 7001_ $$00000-0003-3569-8990$$aStefanis, Leonidas$$b46
000257587 7001_ $$aSimitsi, Athina Maria$$b47
000257587 7001_ $$00000-0002-0600-6820$$aValente, Enza Maria$$b48
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000257587 7001_ $$aZecchinelli, Anna$$b51
000257587 7001_ $$aPezzoli, Gianni$$b52
000257587 7001_ $$aBrighina, Laura$$b53
000257587 7001_ $$aFerrarese, Carlo$$b54
000257587 7001_ $$aAnnesi, Grazia$$b55
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000257587 7001_ $$aGagliardi, Monica$$b57
000257587 7001_ $$aMatsuo, Hirotaka$$b58
000257587 7001_ $$aNakayama, Akiyoshi$$b59
000257587 7001_ $$aHattori, Nobutaka$$b60
000257587 7001_ $$aNishioka, Kenya$$b61
000257587 7001_ $$00000-0003-4118-8233$$aChung, Sun Ju$$b62
000257587 7001_ $$aKim, Yun Joong$$b63
000257587 7001_ $$aKolber, Pierre$$b64
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000257587 7001_ $$aBloem, Bastiaan R$$b66
000257587 7001_ $$aAasly, Jan$$b67
000257587 7001_ $$00000-0002-6723-6865$$aToft, Mathias$$b68
000257587 7001_ $$aPihlstrøm, Lasse$$b69
000257587 7001_ $$aGuedes, Leonor Correia$$b70
000257587 7001_ $$00000-0003-3950-5113$$aFerreira, Joaquim J$$b71
000257587 7001_ $$00000-0002-3508-3438$$aBardien, Soraya$$b72
000257587 7001_ $$aCarr, Jonathan$$b73
000257587 7001_ $$00000-0002-3781-0854$$aTolosa, Eduardo$$b74
000257587 7001_ $$00000-0003-3246-6641$$aEzquerra, Mario$$b75
000257587 7001_ $$aPastor, Pau$$b76
000257587 7001_ $$aDiez-Fairen, Monica$$b77
000257587 7001_ $$aWirdefeldt, Karin$$b78
000257587 7001_ $$aPedersen, Nancy$$b79
000257587 7001_ $$aRan, Caroline$$b80
000257587 7001_ $$aBelin, Andrea C$$b81
000257587 7001_ $$aPuschmann, Andreas$$b82
000257587 7001_ $$aRödström, Emil Ygland$$b83
000257587 7001_ $$aClarke, Carl E$$b84
000257587 7001_ $$aMorrison, Karen E$$b85
000257587 7001_ $$00000-0001-5835-669X$$aTan, Manuela$$b86
000257587 7001_ $$aKrainc, Dimitri$$b87
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000257587 7001_ $$aFarrer, Matt J$$b89
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000257587 7001_ $$0P:(DE-2719)2320009$$aGasser, Thomas$$b91$$udzne
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000257587 7001_ $$aGenetics, Comprehensive Unbiased Risk Factor Assessment for$$b93
000257587 7001_ $$aDisease, Environment in Parkinson's$$b94$$eCollaboration Author
000257587 7001_ $$aTruong, Thérèse$$b95
000257587 7001_ $$00000-0001-9724-5490$$aElbaz, Alexis$$b96
000257587 773__ $$0PERI:(DE-600)2041249-6$$a10.1002/mds.29337$$gVol. 38, no. 4, p. 604 - 615$$n4$$p604 - 615$$tMovement disorders$$v38$$x0885-3185$$y2023
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