TY  - JOUR
AU  - Sugier, Pierre-Emmanuel
AU  - Lucotte, Elise A
AU  - Domenighetti, Cloé
AU  - Law, Matthew H
AU  - Iles, Mark M
AU  - Brown, Kevin
AU  - Amos, Christopher
AU  - McKay, James D
AU  - Hung, Rayjean J
AU  - Karimi, Mojgan
AU  - Bacq-Daian, Delphine
AU  - Boland-Augé, Anne
AU  - Olaso, Robert
AU  - Deleuze, Jean-François
AU  - Lesueur, Fabienne
AU  - Ostroumova, Evgenia
AU  - Kesminiene, Ausrele
AU  - de Vathaire, Florent
AU  - Guénel, Pascal
AU  - Sreelatha, Ashwin Ashok Kumar
AU  - Schulte, Claudia
AU  - Grover, Sandeep
AU  - May, Patrick
AU  - Bobbili, Dheeraj R
AU  - Radivojkov-Blagojevic, Milena
AU  - Lichtner, Peter
AU  - Singleton, Andrew B
AU  - Hernandez, Dena Michelle Godwin
AU  - Edsall, Connor
AU  - Mellick, George D
AU  - Zimprich, Alexander
AU  - Pirker, Walter
AU  - Rogaeva, Ekaterina
AU  - Lang, Anthony E
AU  - Koks, Sulev
AU  - Taba, Pille
AU  - Lesage, Suzanne
AU  - Brice, Alexis
AU  - Corvol, Jean-Christophe
AU  - Chartier-Harlin, Marie-Christine
AU  - Mutez, Eugénie
AU  - Brockmann, Kathrin
AU  - Deutschländer, Angela B
AU  - Hadjigeorgiou, Georges M
AU  - Dardiotis, Efthimios
AU  - Stefanis, Leonidas
AU  - Simitsi, Athina Maria
AU  - Valente, Enza Maria
AU  - Petrucci, Simona
AU  - Straniero, Letizia
AU  - Zecchinelli, Anna
AU  - Pezzoli, Gianni
AU  - Brighina, Laura
AU  - Ferrarese, Carlo
AU  - Annesi, Grazia
AU  - Quattrone, Andrea
AU  - Gagliardi, Monica
AU  - Matsuo, Hirotaka
AU  - Nakayama, Akiyoshi
AU  - Hattori, Nobutaka
AU  - Nishioka, Kenya
AU  - Chung, Sun Ju
AU  - Kim, Yun Joong
AU  - Kolber, Pierre
AU  - van de Warrenburg, Bart P C
AU  - Bloem, Bastiaan R
AU  - Aasly, Jan
AU  - Toft, Mathias
AU  - Pihlstrøm, Lasse
AU  - Guedes, Leonor Correia
AU  - Ferreira, Joaquim J
AU  - Bardien, Soraya
AU  - Carr, Jonathan
AU  - Tolosa, Eduardo
AU  - Ezquerra, Mario
AU  - Pastor, Pau
AU  - Diez-Fairen, Monica
AU  - Wirdefeldt, Karin
AU  - Pedersen, Nancy
AU  - Ran, Caroline
AU  - Belin, Andrea C
AU  - Puschmann, Andreas
AU  - Rödström, Emil Ygland
AU  - Clarke, Carl E
AU  - Morrison, Karen E
AU  - Tan, Manuela
AU  - Krainc, Dimitri
AU  - Burbulla, Lena F
AU  - Farrer, Matt J
AU  - Kruger, Rejko
AU  - Gasser, Thomas
AU  - Sharma, Manu
AU  - Genetics, Comprehensive Unbiased Risk Factor Assessment for
AU  - Truong, Thérèse
AU  - Elbaz, Alexis
TI  - Investigation of Shared Genetic Risk Factors Between Parkinson's Disease and Cancers.
JO  - Movement disorders
VL  - 38
IS  - 4
SN  - 0885-3185
CY  - New York, NY
PB  - Wiley
M1  - DZNE-2023-00463
SP  - 604 - 615
PY  - 2023
AB  - Epidemiological studies that examined the association between Parkinson's disease (PD) and cancers led to inconsistent results, but they face a number of methodological difficulties.We used results from genome-wide association studies (GWASs) to study the genetic correlation between PD and different cancers to identify common genetic risk factors.We used individual data for participants of European ancestry from the Courage-PD (Comprehensive Unbiased Risk Factor Assessment for Genetics and Environment in Parkinson's Disease; PD, N = 16,519) and EPITHYR (differentiated thyroid cancer, N = 3527) consortia and summary statistics of GWASs from iPDGC (International Parkinson Disease Genomics Consortium; PD, N = 482,730), Melanoma Meta-Analysis Consortium (MMAC), Breast Cancer Association Consortium (breast cancer), the Prostate Cancer Association Group to Investigate Cancer Associated Alterations in the Genome (prostate cancer), International Lung Cancer Consortium (lung cancer), and Ovarian Cancer Association Consortium (ovarian cancer) (N comprised between 36,017 and 228,951 for cancer GWASs). We estimated the genetic correlation between PD and cancers using linkage disequilibrium score regression. We studied the association between PD and polymorphisms associated with cancers, and vice versa, using cross-phenotypes polygenic risk score (PRS) analyses.We confirmed a previously reported positive genetic correlation of PD with melanoma (Gcorr = 0.16 [0.04; 0.28]) and reported an additional significant positive correlation of PD with prostate cancer (Gcorr = 0.11 [0.03; 0.19]). There was a significant inverse association between the PRS for ovarian cancer and PD (odds ratio [OR] = 0.89 [0.84; 0.94]). Conversely, the PRS of PD was positively associated with breast cancer (OR = 1.08 [1.06; 1.10]) and inversely associated with ovarian cancer (OR = 0.95 [0.91; 0.99]). The association between PD and ovarian cancer was mostly driven by rs183211 located in an intron of the NSF gene (17q21.31).We show evidence in favor of a contribution of pleiotropic genes to the association between PD and specific cancers. © 2023 The Authors. Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society. This article has been contributed to by U.S. Government employees and their work is in the public domain in the USA.
KW  - Humans
KW  - Male
KW  - Female
KW  - Parkinson Disease: epidemiology
KW  - Parkinson Disease: genetics
KW  - Genome-Wide Association Study
KW  - Genetic Predisposition to Disease: genetics
KW  - Polymorphism, Single Nucleotide: genetics
KW  - Melanoma: epidemiology
KW  - Melanoma: genetics
KW  - Prostatic Neoplasms
KW  - Ovarian Neoplasms
KW  - Risk Factors
KW  - Lung Neoplasms
KW  - Parkinson's disease (Other)
KW  - cancer (Other)
KW  - genetic correlation (Other)
KW  - pleiotropy (Other)
KW  - polygenic risk score (Other)
LB  - PUB:(DE-HGF)16
C2  - pmc:PMC10334300
C6  - pmid:36788297
DO  - DOI:10.1002/mds.29337
UR  - https://pub.dzne.de/record/257587
ER  -