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@ARTICLE{Sugier:257587,
author = {Sugier, Pierre-Emmanuel and Lucotte, Elise A and
Domenighetti, Cloé and Law, Matthew H and Iles, Mark M and
Brown, Kevin and Amos, Christopher and McKay, James D and
Hung, Rayjean J and Karimi, Mojgan and Bacq-Daian, Delphine
and Boland-Augé, Anne and Olaso, Robert and Deleuze,
Jean-François and Lesueur, Fabienne and Ostroumova, Evgenia
and Kesminiene, Ausrele and de Vathaire, Florent and
Guénel, Pascal and Sreelatha, Ashwin Ashok Kumar and
Schulte, Claudia and Grover, Sandeep and May, Patrick and
Bobbili, Dheeraj R and Radivojkov-Blagojevic, Milena and
Lichtner, Peter and Singleton, Andrew B and Hernandez, Dena
Michelle Godwin and Edsall, Connor and Mellick, George D and
Zimprich, Alexander and Pirker, Walter and Rogaeva,
Ekaterina and Lang, Anthony E and Koks, Sulev and Taba,
Pille and Lesage, Suzanne and Brice, Alexis and Corvol,
Jean-Christophe and Chartier-Harlin, Marie-Christine and
Mutez, Eugénie and Brockmann, Kathrin and Deutschländer,
Angela B and Hadjigeorgiou, Georges M and Dardiotis,
Efthimios and Stefanis, Leonidas and Simitsi, Athina Maria
and Valente, Enza Maria and Petrucci, Simona and Straniero,
Letizia and Zecchinelli, Anna and Pezzoli, Gianni and
Brighina, Laura and Ferrarese, Carlo and Annesi, Grazia and
Quattrone, Andrea and Gagliardi, Monica and Matsuo, Hirotaka
and Nakayama, Akiyoshi and Hattori, Nobutaka and Nishioka,
Kenya and Chung, Sun Ju and Kim, Yun Joong and Kolber,
Pierre and van de Warrenburg, Bart P C and Bloem, Bastiaan R
and Aasly, Jan and Toft, Mathias and Pihlstrøm, Lasse and
Guedes, Leonor Correia and Ferreira, Joaquim J and Bardien,
Soraya and Carr, Jonathan and Tolosa, Eduardo and Ezquerra,
Mario and Pastor, Pau and Diez-Fairen, Monica and
Wirdefeldt, Karin and Pedersen, Nancy and Ran, Caroline and
Belin, Andrea C and Puschmann, Andreas and Rödström, Emil
Ygland and Clarke, Carl E and Morrison, Karen E and Tan,
Manuela and Krainc, Dimitri and Burbulla, Lena F and Farrer,
Matt J and Kruger, Rejko and Gasser, Thomas and Sharma, Manu
and Genetics, Comprehensive Unbiased Risk Factor Assessment
for and Truong, Thérèse and Elbaz, Alexis},
collaboration = {consortium, EPITHYR and Disease, Environment in
Parkinson's},
title = {{I}nvestigation of {S}hared {G}enetic {R}isk {F}actors
{B}etween {P}arkinson's {D}isease and {C}ancers.},
journal = {Movement disorders},
volume = {38},
number = {4},
issn = {0885-3185},
address = {New York, NY},
publisher = {Wiley},
reportid = {DZNE-2023-00463},
pages = {604 - 615},
year = {2023},
abstract = {Epidemiological studies that examined the association
between Parkinson's disease (PD) and cancers led to
inconsistent results, but they face a number of
methodological difficulties.We used results from genome-wide
association studies (GWASs) to study the genetic correlation
between PD and different cancers to identify common genetic
risk factors.We used individual data for participants of
European ancestry from the Courage-PD (Comprehensive
Unbiased Risk Factor Assessment for Genetics and Environment
in Parkinson's Disease; PD, N = 16,519) and EPITHYR
(differentiated thyroid cancer, N = 3527) consortia and
summary statistics of GWASs from iPDGC (International
Parkinson Disease Genomics Consortium; PD, N = 482,730),
Melanoma Meta-Analysis Consortium (MMAC), Breast Cancer
Association Consortium (breast cancer), the Prostate Cancer
Association Group to Investigate Cancer Associated
Alterations in the Genome (prostate cancer), International
Lung Cancer Consortium (lung cancer), and Ovarian Cancer
Association Consortium (ovarian cancer) (N comprised between
36,017 and 228,951 for cancer GWASs). We estimated the
genetic correlation between PD and cancers using linkage
disequilibrium score regression. We studied the association
between PD and polymorphisms associated with cancers, and
vice versa, using cross-phenotypes polygenic risk score
(PRS) analyses.We confirmed a previously reported positive
genetic correlation of PD with melanoma (Gcorr = 0.16 [0.04;
0.28]) and reported an additional significant positive
correlation of PD with prostate cancer (Gcorr = 0.11 [0.03;
0.19]). There was a significant inverse association between
the PRS for ovarian cancer and PD (odds ratio [OR] = 0.89
[0.84; 0.94]). Conversely, the PRS of PD was positively
associated with breast cancer (OR = 1.08 [1.06; 1.10]) and
inversely associated with ovarian cancer (OR = 0.95 [0.91;
0.99]). The association between PD and ovarian cancer was
mostly driven by rs183211 located in an intron of the NSF
gene (17q21.31).We show evidence in favor of a contribution
of pleiotropic genes to the association between PD and
specific cancers. © 2023 The Authors. Movement Disorders
published by Wiley Periodicals LLC on behalf of
International Parkinson and Movement Disorder Society. This
article has been contributed to by U.S. Government employees
and their work is in the public domain in the USA.},
keywords = {Humans / Male / Female / Parkinson Disease: epidemiology /
Parkinson Disease: genetics / Genome-Wide Association Study
/ Genetic Predisposition to Disease: genetics /
Polymorphism, Single Nucleotide: genetics / Melanoma:
epidemiology / Melanoma: genetics / Prostatic Neoplasms /
Ovarian Neoplasms / Risk Factors / Lung Neoplasms /
Parkinson's disease (Other) / cancer (Other) / genetic
correlation (Other) / pleiotropy (Other) / polygenic risk
score (Other)},
cin = {AG Gasser / AG Burbulla},
ddc = {610},
cid = {I:(DE-2719)1210000 / I:(DE-2719)5000074},
pnm = {353 - Clinical and Health Care Research (POF4-353) / 352 -
Disease Mechanisms (POF4-352)},
pid = {G:(DE-HGF)POF4-353 / G:(DE-HGF)POF4-352},
typ = {PUB:(DE-HGF)16},
pmc = {pmc:PMC10334300},
pubmed = {pmid:36788297},
doi = {10.1002/mds.29337},
url = {https://pub.dzne.de/record/257587},
}
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