%0 Journal Article
%A Dafsari, Forugh S
%A Bewernick, Bettina
%A Böhringer, Sabine
%A Domschke, Katharina
%A Elsaesser, Moritz
%A Löbner, Margrit
%A Luppa, Melanie
%A Preis, Lukas
%A Püsken, Julia
%A Schmitt, Sandra
%A Szekely, Andreea-Johanna
%A Hellmich, Martin
%A Müller, Wiebke
%A Wagner, Michael
%A Peters, Oliver
%A Frölich, Lutz
%A Riedel-Heller, Steffi
%A Schramm, Elisabeth
%A Hautzinger, Martin
%A Jessen, Frank
%T Cognitive Behavioral Therapy for Late-Life Depression (CBTlate): Results of a Multicenter, Randomized, Observer-Blinded, Controlled Trial.
%J Psychotherapy and psychosomatics
%V 92
%@ 0033-3190
%C Basel
%I Karger
%M DZNE-2023-00472
%P 180-192
%D 2023
%X Different psychotherapeutic interventions for late-life depression (LLD) have been proposed, but their evaluation in large, multicenter trials is rare.The present study evaluated the efficacy of a specific cognitive behavioral therapy (CBT) for LLD (LLD-CBT) in comparison with a supportive unspecific intervention (SUI), both administered in a specialist psychiatric outpatient setting.In this randomized, controlled, parallel group trial, we recruited participants (≥60 years) with moderate to severe depression at 7 trial sites in Germany. Participants were randomly assigned to the LLD-CBT or SUI group. The primary outcome was depression severity at the end of treatment measured by change on the Geriatric Depression Scale (GDS). Secondary outcomes included change in observer-rated depression, anxiety, sleep ratings, and quality of life throughout the treatment phase and at 6-month follow-up.Between October 1, 2018, and November 11, 2020, we randomly assigned 251 patients to either LLD-CBT (n = 126) or SUI (n = 125), of whom 229 provided primary-outcome data. There was no significant between-group difference in the change in GDS scores at the end of treatment (estimated marginal mean difference: -1.01 [95
%K Humans
%K Aged
%K Depression: therapy
%K Depression: psychology
%K Quality of Life
%K Treatment Outcome
%K Cognitive Behavioral Therapy: methods
%K Depressive Disorder: therapy
%K Cognitive behavioral therapy (Other)
%K Geriatric depression (Other)
%K Late-life depression (Other)
%K Randomized controlled trial (Other)
%K Supportive psychotherapy (Other)
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:37004508
%R 10.1159/000529445
%U https://pub.dzne.de/record/257675