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000257675 1001_ $$aDafsari, Forugh S$$b0
000257675 245__ $$aCognitive Behavioral Therapy for Late-Life Depression (CBTlate): Results of a Multicenter, Randomized, Observer-Blinded, Controlled Trial.
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000257675 520__ $$aDifferent psychotherapeutic interventions for late-life depression (LLD) have been proposed, but their evaluation in large, multicenter trials is rare.The present study evaluated the efficacy of a specific cognitive behavioral therapy (CBT) for LLD (LLD-CBT) in comparison with a supportive unspecific intervention (SUI), both administered in a specialist psychiatric outpatient setting.In this randomized, controlled, parallel group trial, we recruited participants (≥60 years) with moderate to severe depression at 7 trial sites in Germany. Participants were randomly assigned to the LLD-CBT or SUI group. The primary outcome was depression severity at the end of treatment measured by change on the Geriatric Depression Scale (GDS). Secondary outcomes included change in observer-rated depression, anxiety, sleep ratings, and quality of life throughout the treatment phase and at 6-month follow-up.Between October 1, 2018, and November 11, 2020, we randomly assigned 251 patients to either LLD-CBT (n = 126) or SUI (n = 125), of whom 229 provided primary-outcome data. There was no significant between-group difference in the change in GDS scores at the end of treatment (estimated marginal mean difference: -1.01 [95% CI: -2.88 to 0.86]; p = 0.287). Secondary analyses showed significant improvements in several outcomes after 8 weeks and at follow-up in both treatment arms.Our data suggest that LLD-specific CBT and a supportive unspecific treatment both provide clinical benefit in patients with moderate to severe LLD without evidence for superiority of LLD-CBT.
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000257675 650_7 $$2Other$$aCognitive behavioral therapy
000257675 650_7 $$2Other$$aGeriatric depression
000257675 650_7 $$2Other$$aLate-life depression
000257675 650_7 $$2Other$$aRandomized controlled trial
000257675 650_7 $$2Other$$aSupportive psychotherapy
000257675 650_2 $$2MeSH$$aHumans
000257675 650_2 $$2MeSH$$aAged
000257675 650_2 $$2MeSH$$aDepression: therapy
000257675 650_2 $$2MeSH$$aDepression: psychology
000257675 650_2 $$2MeSH$$aQuality of Life
000257675 650_2 $$2MeSH$$aTreatment Outcome
000257675 650_2 $$2MeSH$$aCognitive Behavioral Therapy: methods
000257675 650_2 $$2MeSH$$aDepressive Disorder: therapy
000257675 7001_ $$aBewernick, Bettina$$b1
000257675 7001_ $$aBöhringer, Sabine$$b2
000257675 7001_ $$aDomschke, Katharina$$b3
000257675 7001_ $$aElsaesser, Moritz$$b4
000257675 7001_ $$aLöbner, Margrit$$b5
000257675 7001_ $$aLuppa, Melanie$$b6
000257675 7001_ $$0P:(DE-2719)9000703$$aPreis, Lukas$$b7$$udzne
000257675 7001_ $$aPüsken, Julia$$b8
000257675 7001_ $$aSchmitt, Sandra$$b9
000257675 7001_ $$aSzekely, Andreea-Johanna$$b10
000257675 7001_ $$aHellmich, Martin$$b11
000257675 7001_ $$aMüller, Wiebke$$b12
000257675 7001_ $$0P:(DE-2719)2000057$$aWagner, Michael$$b13$$udzne
000257675 7001_ $$0P:(DE-2719)2811024$$aPeters, Oliver$$b14$$udzne
000257675 7001_ $$0P:(DE-2719)9001189$$aFrölich, Lutz$$b15$$udzne
000257675 7001_ $$aRiedel-Heller, Steffi$$b16
000257675 7001_ $$aSchramm, Elisabeth$$b17
000257675 7001_ $$aHautzinger, Martin$$b18
000257675 7001_ $$0P:(DE-2719)2000032$$aJessen, Frank$$b19$$eLast author$$udzne
000257675 773__ $$0PERI:(DE-600)1472321-9$$a10.1159/000529445$$gp. 1 - 13$$p180-192$$tPsychotherapy and psychosomatics$$v92$$x0033-3190$$y2023
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