TY  - JOUR
AU  - Dafsari, Forugh S
AU  - Bewernick, Bettina
AU  - Böhringer, Sabine
AU  - Domschke, Katharina
AU  - Elsaesser, Moritz
AU  - Löbner, Margrit
AU  - Luppa, Melanie
AU  - Preis, Lukas
AU  - Püsken, Julia
AU  - Schmitt, Sandra
AU  - Szekely, Andreea-Johanna
AU  - Hellmich, Martin
AU  - Müller, Wiebke
AU  - Wagner, Michael
AU  - Peters, Oliver
AU  - Frölich, Lutz
AU  - Riedel-Heller, Steffi
AU  - Schramm, Elisabeth
AU  - Hautzinger, Martin
AU  - Jessen, Frank
TI  - Cognitive Behavioral Therapy for Late-Life Depression (CBTlate): Results of a Multicenter, Randomized, Observer-Blinded, Controlled Trial.
JO  - Psychotherapy and psychosomatics
VL  - 92
SN  - 0033-3190
CY  - Basel
PB  - Karger
M1  - DZNE-2023-00472
SP  - 180-192
PY  - 2023
AB  - Different psychotherapeutic interventions for late-life depression (LLD) have been proposed, but their evaluation in large, multicenter trials is rare.The present study evaluated the efficacy of a specific cognitive behavioral therapy (CBT) for LLD (LLD-CBT) in comparison with a supportive unspecific intervention (SUI), both administered in a specialist psychiatric outpatient setting.In this randomized, controlled, parallel group trial, we recruited participants (≥60 years) with moderate to severe depression at 7 trial sites in Germany. Participants were randomly assigned to the LLD-CBT or SUI group. The primary outcome was depression severity at the end of treatment measured by change on the Geriatric Depression Scale (GDS). Secondary outcomes included change in observer-rated depression, anxiety, sleep ratings, and quality of life throughout the treatment phase and at 6-month follow-up.Between October 1, 2018, and November 11, 2020, we randomly assigned 251 patients to either LLD-CBT (n = 126) or SUI (n = 125), of whom 229 provided primary-outcome data. There was no significant between-group difference in the change in GDS scores at the end of treatment (estimated marginal mean difference: -1.01 [95
KW  - Humans
KW  - Aged
KW  - Depression: therapy
KW  - Depression: psychology
KW  - Quality of Life
KW  - Treatment Outcome
KW  - Cognitive Behavioral Therapy: methods
KW  - Depressive Disorder: therapy
KW  - Cognitive behavioral therapy (Other)
KW  - Geriatric depression (Other)
KW  - Late-life depression (Other)
KW  - Randomized controlled trial (Other)
KW  - Supportive psychotherapy (Other)
LB  - PUB:(DE-HGF)16
C6  - pmid:37004508
DO  - DOI:10.1159/000529445
UR  - https://pub.dzne.de/record/257675
ER  -