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@ARTICLE{Dafsari:257675,
      author       = {Dafsari, Forugh S and Bewernick, Bettina and Böhringer,
                      Sabine and Domschke, Katharina and Elsaesser, Moritz and
                      Löbner, Margrit and Luppa, Melanie and Preis, Lukas and
                      Püsken, Julia and Schmitt, Sandra and Szekely,
                      Andreea-Johanna and Hellmich, Martin and Müller, Wiebke and
                      Wagner, Michael and Peters, Oliver and Frölich, Lutz and
                      Riedel-Heller, Steffi and Schramm, Elisabeth and Hautzinger,
                      Martin and Jessen, Frank},
      title        = {{C}ognitive {B}ehavioral {T}herapy for {L}ate-{L}ife
                      {D}epression ({CBT}late): {R}esults of a {M}ulticenter,
                      {R}andomized, {O}bserver-{B}linded, {C}ontrolled {T}rial.},
      journal      = {Psychotherapy and psychosomatics},
      volume       = {92},
      issn         = {0033-3190},
      address      = {Basel},
      publisher    = {Karger},
      reportid     = {DZNE-2023-00472},
      pages        = {180-192},
      year         = {2023},
      abstract     = {Different psychotherapeutic interventions for late-life
                      depression (LLD) have been proposed, but their evaluation in
                      large, multicenter trials is rare.The present study
                      evaluated the efficacy of a specific cognitive behavioral
                      therapy (CBT) for LLD (LLD-CBT) in comparison with a
                      supportive unspecific intervention (SUI), both administered
                      in a specialist psychiatric outpatient setting.In this
                      randomized, controlled, parallel group trial, we recruited
                      participants (≥60 years) with moderate to severe
                      depression at 7 trial sites in Germany. Participants were
                      randomly assigned to the LLD-CBT or SUI group. The primary
                      outcome was depression severity at the end of treatment
                      measured by change on the Geriatric Depression Scale (GDS).
                      Secondary outcomes included change in observer-rated
                      depression, anxiety, sleep ratings, and quality of life
                      throughout the treatment phase and at 6-month
                      follow-up.Between October 1, 2018, and November 11, 2020, we
                      randomly assigned 251 patients to either LLD-CBT (n = 126)
                      or SUI (n = 125), of whom 229 provided primary-outcome data.
                      There was no significant between-group difference in the
                      change in GDS scores at the end of treatment (estimated
                      marginal mean difference: -1.01 $[95\%$ CI: -2.88 to 0.86];
                      p = 0.287). Secondary analyses showed significant
                      improvements in several outcomes after 8 weeks and at
                      follow-up in both treatment arms.Our data suggest that
                      LLD-specific CBT and a supportive unspecific treatment both
                      provide clinical benefit in patients with moderate to severe
                      LLD without evidence for superiority of LLD-CBT.},
      keywords     = {Humans / Aged / Depression: therapy / Depression:
                      psychology / Quality of Life / Treatment Outcome / Cognitive
                      Behavioral Therapy: methods / Depressive Disorder: therapy /
                      Cognitive behavioral therapy (Other) / Geriatric depression
                      (Other) / Late-life depression (Other) / Randomized
                      controlled trial (Other) / Supportive psychotherapy (Other)},
      cin          = {AG Jessen},
      ddc          = {610},
      cid          = {I:(DE-2719)1011102},
      pnm          = {353 - Clinical and Health Care Research (POF4-353)},
      pid          = {G:(DE-HGF)POF4-353},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:37004508},
      doi          = {10.1159/000529445},
      url          = {https://pub.dzne.de/record/257675},
}