Home > Publications Database > Cognitive Behavioral Therapy for Late-Life Depression (CBTlate): Results of a Multicenter, Randomized, Observer-Blinded, Controlled Trial. > print

001     257675
005     20231120155340.0
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037 _ _ |a DZNE-2023-00472
041 _ _ |a English
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100 1 _ |a Dafsari, Forugh S
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245 _ _ |a Cognitive Behavioral Therapy for Late-Life Depression (CBTlate): Results of a Multicenter, Randomized, Observer-Blinded, Controlled Trial.
260 _ _ |a Basel
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520 _ _ |a Different psychotherapeutic interventions for late-life depression (LLD) have been proposed, but their evaluation in large, multicenter trials is rare.The present study evaluated the efficacy of a specific cognitive behavioral therapy (CBT) for LLD (LLD-CBT) in comparison with a supportive unspecific intervention (SUI), both administered in a specialist psychiatric outpatient setting.In this randomized, controlled, parallel group trial, we recruited participants (≥60 years) with moderate to severe depression at 7 trial sites in Germany. Participants were randomly assigned to the LLD-CBT or SUI group. The primary outcome was depression severity at the end of treatment measured by change on the Geriatric Depression Scale (GDS). Secondary outcomes included change in observer-rated depression, anxiety, sleep ratings, and quality of life throughout the treatment phase and at 6-month follow-up.Between October 1, 2018, and November 11, 2020, we randomly assigned 251 patients to either LLD-CBT (n = 126) or SUI (n = 125), of whom 229 provided primary-outcome data. There was no significant between-group difference in the change in GDS scores at the end of treatment (estimated marginal mean difference: -1.01 [95% CI: -2.88 to 0.86]; p = 0.287). Secondary analyses showed significant improvements in several outcomes after 8 weeks and at follow-up in both treatment arms.Our data suggest that LLD-specific CBT and a supportive unspecific treatment both provide clinical benefit in patients with moderate to severe LLD without evidence for superiority of LLD-CBT.
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650 _ 7 |a Cognitive behavioral therapy
|2 Other
650 _ 7 |a Geriatric depression
|2 Other
650 _ 7 |a Late-life depression
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650 _ 7 |a Randomized controlled trial
|2 Other
650 _ 7 |a Supportive psychotherapy
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650 _ 2 |a Humans
|2 MeSH
650 _ 2 |a Aged
|2 MeSH
650 _ 2 |a Depression: therapy
|2 MeSH
650 _ 2 |a Depression: psychology
|2 MeSH
650 _ 2 |a Quality of Life
|2 MeSH
650 _ 2 |a Treatment Outcome
|2 MeSH
650 _ 2 |a Cognitive Behavioral Therapy: methods
|2 MeSH
650 _ 2 |a Depressive Disorder: therapy
|2 MeSH
700 1 _ |a Bewernick, Bettina
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700 1 _ |a Böhringer, Sabine
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700 1 _ |a Domschke, Katharina
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700 1 _ |a Elsaesser, Moritz
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700 1 _ |a Löbner, Margrit
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700 1 _ |a Luppa, Melanie
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700 1 _ |a Preis, Lukas
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700 1 _ |a Püsken, Julia
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700 1 _ |a Schmitt, Sandra
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700 1 _ |a Szekely, Andreea-Johanna
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700 1 _ |a Hellmich, Martin
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700 1 _ |a Müller, Wiebke
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700 1 _ |a Wagner, Michael
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700 1 _ |a Peters, Oliver
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700 1 _ |a Frölich, Lutz
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700 1 _ |a Riedel-Heller, Steffi
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700 1 _ |a Schramm, Elisabeth
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700 1 _ |a Hautzinger, Martin
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700 1 _ |a Jessen, Frank
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