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000257684 041__ $$aEnglish
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000257684 1001_ $$0P:(DE-2719)9001275$$aRamirez, Lisa Marie$$b0$$eFirst author$$udzne
000257684 245__ $$aMolecular-level interplay between intrinsically disordered clients and Hsp90.
000257684 260__ $$aLondon$$bCurrent Biology Ltd.$$c2023
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000257684 520__ $$aProteostasis is maintained by a network of molecular chaperones, a prominent member of which is the 90-kilodalton heat shock protein Hsp90. The chaperone function of Hsp90 has been extensively reviewed previously, emphasizing its ATPase activity and remodeling of folded client proteins. Experimental evidence implicating Hsp90 in neurodegenerative diseases has bolstered interest in the noncanonical chaperoning of intrinsically disordered protein (IDPs), however the interplay between Hsp90 and its disordered clients remains poorly understood. In this review we describe recent advances that have contributed to our understanding of the intricate mechanisms characterizing Hsp90-mediated chaperoning of the IDPs tau and α-synuclein and survey emerging insights into the modulation of the chaperone-client interplay in the context of neurodegeneration.
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000257684 650_7 $$2Other$$aα-Synuclein
000257684 650_7 $$2Other$$aα-Synuclein
000257684 650_7 $$2Other$$aAlzheimer's disease
000257684 650_7 $$2Other$$aHeat shock protein
000257684 650_7 $$2Other$$aHsp90
000257684 650_7 $$2Other$$aStructure
000257684 650_7 $$2Other$$aTau
000257684 650_7 $$2Other$$aα-Synuclein
000257684 650_7 $$2NLM Chemicals$$aHSP90 Heat-Shock Proteins
000257684 650_7 $$2NLM Chemicals$$aMolecular Chaperones
000257684 650_7 $$2NLM Chemicals$$aIntrinsically Disordered Proteins
000257684 650_2 $$2MeSH$$aHumans
000257684 650_2 $$2MeSH$$aHSP90 Heat-Shock Proteins: metabolism
000257684 650_2 $$2MeSH$$aMolecular Chaperones
000257684 650_2 $$2MeSH$$aProteostasis
000257684 650_2 $$2MeSH$$aIntrinsically Disordered Proteins: metabolism
000257684 650_2 $$2MeSH$$aNeurodegenerative Diseases
000257684 7001_ $$0P:(DE-2719)2810591$$aZweckstetter, Markus$$b1$$eLast author$$udzne
000257684 773__ $$0PERI:(DE-600)2019216-2$$a10.1016/j.cbpa.2023.102304$$gVol. 74, p. 102304 -$$p102304$$tCurrent opinion in chemical biology$$v74$$x1367-5931$$y2023
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