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001     257684
005     20250411153447.0
024 7 _ |a 10.1016/j.cbpa.2023.102304
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024 7 _ |a pmid:37068388
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024 7 _ |a 1367-5931
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024 7 _ |a 1879-0402
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037 _ _ |a DZNE-2023-00481
041 _ _ |a English
082 _ _ |a 570
100 1 _ |a Ramirez, Lisa Marie
|0 P:(DE-2719)9001275
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245 _ _ |a Molecular-level interplay between intrinsically disordered clients and Hsp90.
260 _ _ |a London
|c 2023
|b Current Biology Ltd.
336 7 _ |a article
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336 7 _ |a Journal Article
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520 _ _ |a Proteostasis is maintained by a network of molecular chaperones, a prominent member of which is the 90-kilodalton heat shock protein Hsp90. The chaperone function of Hsp90 has been extensively reviewed previously, emphasizing its ATPase activity and remodeling of folded client proteins. Experimental evidence implicating Hsp90 in neurodegenerative diseases has bolstered interest in the noncanonical chaperoning of intrinsically disordered protein (IDPs), however the interplay between Hsp90 and its disordered clients remains poorly understood. In this review we describe recent advances that have contributed to our understanding of the intricate mechanisms characterizing Hsp90-mediated chaperoning of the IDPs tau and α-synuclein and survey emerging insights into the modulation of the chaperone-client interplay in the context of neurodegeneration.
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650 _ 7 |a α-Synuclein
|2 Other
650 _ 7 |a α-Synuclein
|2 Other
650 _ 7 |a Alzheimer's disease
|2 Other
650 _ 7 |a Heat shock protein
|2 Other
650 _ 7 |a Hsp90
|2 Other
650 _ 7 |a Structure
|2 Other
650 _ 7 |a Tau
|2 Other
650 _ 7 |a α-Synuclein
|2 Other
650 _ 7 |a HSP90 Heat-Shock Proteins
|2 NLM Chemicals
650 _ 7 |a Molecular Chaperones
|2 NLM Chemicals
650 _ 7 |a Intrinsically Disordered Proteins
|2 NLM Chemicals
650 _ 2 |a Humans
|2 MeSH
650 _ 2 |a HSP90 Heat-Shock Proteins: metabolism
|2 MeSH
650 _ 2 |a Molecular Chaperones
|2 MeSH
650 _ 2 |a Proteostasis
|2 MeSH
650 _ 2 |a Intrinsically Disordered Proteins: metabolism
|2 MeSH
650 _ 2 |a Neurodegenerative Diseases
|2 MeSH
700 1 _ |a Zweckstetter, Markus
|0 P:(DE-2719)2810591
|b 1
|e Last author
|u dzne
773 _ _ |a 10.1016/j.cbpa.2023.102304
|g Vol. 74, p. 102304 -
|0 PERI:(DE-600)2019216-2
|p 102304
|t Current opinion in chemical biology
|v 74
|y 2023
|x 1367-5931
856 4 _ |u https://www.sciencedirect.com/science/article/abs/pii/S136759312300042X?via%3Dihub
856 4 _ |u https://pub.dzne.de/record/257684/files/DZNE-2023-00481_Restricted.pdf
856 4 _ |u https://pub.dzne.de/record/257684/files/DZNE-2023-00481_Restricted.pdf?subformat=pdfa
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910 1 _ |a Deutsches Zentrum für Neurodegenerative Erkrankungen
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910 1 _ |a Deutsches Zentrum für Neurodegenerative Erkrankungen
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