000257690 001__ 257690
000257690 005__ 20240112171713.0
000257690 0247_ $$2pmc$$apmc:PMC10647888
000257690 0247_ $$2doi$$a10.1136/svn-2022-001784
000257690 0247_ $$2pmid$$apmid:36858463
000257690 0247_ $$2ISSN$$a2059-8688
000257690 0247_ $$2ISSN$$a2059-8696
000257690 0247_ $$2altmetric$$aaltmetric:143175226
000257690 037__ $$aDZNE-2023-00487
000257690 041__ $$aEnglish
000257690 082__ $$a610
000257690 1001_ $$00000-0003-0058-2365$$aKlyscz, Philipp$$b0
000257690 245__ $$aRetinal microvascular signs and recurrent vascular events in patients with TIA or minor stroke.
000257690 260__ $$aLondon$$bBMJ$$c2023
000257690 3367_ $$2DRIVER$$aarticle
000257690 3367_ $$2DataCite$$aOutput Types/Journal article
000257690 3367_ $$0PUB:(DE-HGF)16$$2PUB:(DE-HGF)$$aJournal Article$$bjournal$$mjournal$$s1698411393_2085
000257690 3367_ $$2BibTeX$$aARTICLE
000257690 3367_ $$2ORCID$$aJOURNAL_ARTICLE
000257690 3367_ $$00$$2EndNote$$aJournal Article
000257690 520__ $$aRetinal pathologies are an independent risk factor for ischaemic stroke, but research on the predictive value of retinal abnormalities for recurrent vascular events in patients with prior stroke is inconclusive. We investigated the association of retinal pathologies with subsequent vascular events.In a substudy of the Intensified secondary prevention intending a reduction of recurrent events in TIA and minor stroke patients (INSPiRE-TMS) trial, we enrolled patients with recent transient ischaemic attack (TIA) or minor stroke with at least one modifiable risk factor. Primary outcome was the composite of subsequent vascular events. Retinal photographs were taken at baseline and categorised into three different fundus groups by a telemedically linked ophthalmologist.722 patients participated in the current study and 109 major vascular events occurred. After multivariable adjustments, we did not find a significant association between fundus categories and risk for subsequent vascular events (HRs for moderate vascular retinopathy and vascular retinopathy with vessel rarefaction in comparison to no vascular retinopathy 1.03 (95% CI 0.64 to 1.67), p=0.905 and 1.17 (95% CI 0.62 to 2.20), p=0.626). In a selective post hoc analysis in patients with diabetes mellitus and hypertension, patients with vascular retinopathy with vessel rarefaction had a higher risk for recurrent stroke (HR 24.14 (95% CI 2.74 to 212.50), p=0.004).Retinal changes did not predict major subsequent vascular events in patients with recent TIA or minor stroke. Further studies are needed to examine the utility of fundus photography in assessing the risk of stroke recurrence in patients with diabetes mellitus and hypertension.
000257690 536__ $$0G:(DE-HGF)POF4-353$$a353 - Clinical and Health Care Research (POF4-353)$$cPOF4-353$$fPOF IV$$x0
000257690 588__ $$aDataset connected to CrossRef, PubMed, , Journals: pub.dzne.de
000257690 650_7 $$2Other$$acerebral infarction
000257690 650_7 $$2Other$$aischemic attack, transient
000257690 650_7 $$2Other$$astroke
000257690 650_2 $$2MeSH$$aHumans
000257690 650_2 $$2MeSH$$aStroke: diagnosis
000257690 650_2 $$2MeSH$$aStroke: epidemiology
000257690 650_2 $$2MeSH$$aStroke: complications
000257690 650_2 $$2MeSH$$aIschemic Attack, Transient: diagnosis
000257690 650_2 $$2MeSH$$aBrain Ischemia
000257690 650_2 $$2MeSH$$aHypertension: complications
000257690 650_2 $$2MeSH$$aRetinal Diseases: diagnosis
000257690 650_2 $$2MeSH$$aRetinal Diseases: epidemiology
000257690 650_2 $$2MeSH$$aRetinal Diseases: complications
000257690 650_2 $$2MeSH$$aDiabetes Mellitus
000257690 7001_ $$aIhl, Thomas$$b1
000257690 7001_ $$aLaumeier, Inga$$b2
000257690 7001_ $$aSteinicke, Maureen$$b3
000257690 7001_ $$0P:(DE-2719)2811033$$aEndres, Matthias$$b4$$udzne
000257690 7001_ $$aMichelson, Georg$$b5
000257690 7001_ $$aAudebert, Heinrich J$$b6
000257690 773__ $$0PERI:(DE-600)2847692-X$$a10.1136/svn-2022-001784$$gp. svn-2022-001784 -$$n5$$p379-386$$tStroke and vascular neurology$$v8$$x2059-8688$$y2023
000257690 8564_ $$uhttps://pub.dzne.de/record/257690/files/DZNE-2023-00487.pdf$$yOpenAccess
000257690 8564_ $$uhttps://pub.dzne.de/record/257690/files/DZNE-2023-00487.pdf?subformat=pdfa$$xpdfa$$yOpenAccess
000257690 909CO $$ooai:pub.dzne.de:257690$$pdnbdelivery$$pdriver$$pVDB$$popen_access$$popenaire
000257690 9101_ $$0I:(DE-588)1065079516$$6P:(DE-2719)2811033$$aDeutsches Zentrum für Neurodegenerative Erkrankungen$$b4$$kDZNE
000257690 9131_ $$0G:(DE-HGF)POF4-353$$1G:(DE-HGF)POF4-350$$2G:(DE-HGF)POF4-300$$3G:(DE-HGF)POF4$$4G:(DE-HGF)POF$$aDE-HGF$$bGesundheit$$lNeurodegenerative Diseases$$vClinical and Health Care Research$$x0
000257690 9141_ $$y2023
000257690 915__ $$0StatID:(DE-HGF)0160$$2StatID$$aDBCoverage$$bEssential Science Indicators$$d2022-11-12
000257690 915__ $$0LIC:(DE-HGF)CCBYNC4$$2HGFVOC$$aCreative Commons Attribution-NonCommercial CC BY-NC 4.0
000257690 915__ $$0StatID:(DE-HGF)0113$$2StatID$$aWoS$$bScience Citation Index Expanded$$d2022-11-12
000257690 915__ $$0StatID:(DE-HGF)0700$$2StatID$$aFees$$d2022-11-12
000257690 915__ $$0StatID:(DE-HGF)0510$$2StatID$$aOpenAccess
000257690 915__ $$0StatID:(DE-HGF)0561$$2StatID$$aArticle Processing Charges$$d2022-11-12
000257690 915__ $$0StatID:(DE-HGF)0501$$2StatID$$aDBCoverage$$bDOAJ Seal$$d2023-05-02T08:47:10Z
000257690 915__ $$0StatID:(DE-HGF)0500$$2StatID$$aDBCoverage$$bDOAJ$$d2023-05-02T08:47:10Z
000257690 915__ $$0StatID:(DE-HGF)0030$$2StatID$$aPeer Review$$bDOAJ : Anonymous peer review$$d2023-05-02T08:47:10Z
000257690 915__ $$0StatID:(DE-HGF)0200$$2StatID$$aDBCoverage$$bSCOPUS$$d2023-10-27
000257690 915__ $$0StatID:(DE-HGF)0300$$2StatID$$aDBCoverage$$bMedline$$d2023-10-27
000257690 915__ $$0StatID:(DE-HGF)0320$$2StatID$$aDBCoverage$$bPubMed Central$$d2023-10-27
000257690 915__ $$0StatID:(DE-HGF)0199$$2StatID$$aDBCoverage$$bClarivate Analytics Master Journal List$$d2023-10-27
000257690 915__ $$0StatID:(DE-HGF)0150$$2StatID$$aDBCoverage$$bWeb of Science Core Collection$$d2023-10-27
000257690 915__ $$0StatID:(DE-HGF)1110$$2StatID$$aDBCoverage$$bCurrent Contents - Clinical Medicine$$d2023-10-27
000257690 915__ $$0StatID:(DE-HGF)0100$$2StatID$$aJCR$$bSTROKE VASC NEUROL : 2022$$d2023-10-27
000257690 915__ $$0StatID:(DE-HGF)9905$$2StatID$$aIF >= 5$$bSTROKE VASC NEUROL : 2022$$d2023-10-27
000257690 9201_ $$0I:(DE-2719)1811005$$kAG Endres$$lInterdisciplinary Dementia Research$$x0
000257690 980__ $$ajournal
000257690 980__ $$aVDB
000257690 980__ $$aI:(DE-2719)1811005
000257690 980__ $$aUNRESTRICTED
000257690 9801_ $$aFullTexts