TY  - JOUR
AU  - Klyscz, Philipp
AU  - Ihl, Thomas
AU  - Laumeier, Inga
AU  - Steinicke, Maureen
AU  - Endres, Matthias
AU  - Michelson, Georg
AU  - Audebert, Heinrich J
TI  - Retinal microvascular signs and recurrent vascular events in patients with TIA or minor stroke.
JO  - Stroke and vascular neurology
VL  - 8
IS  - 5
SN  - 2059-8688
CY  - London
PB  - BMJ
M1  - DZNE-2023-00487
SP  - 379-386
PY  - 2023
AB  - Retinal pathologies are an independent risk factor for ischaemic stroke, but research on the predictive value of retinal abnormalities for recurrent vascular events in patients with prior stroke is inconclusive. We investigated the association of retinal pathologies with subsequent vascular events.In a substudy of the Intensified secondary prevention intending a reduction of recurrent events in TIA and minor stroke patients (INSPiRE-TMS) trial, we enrolled patients with recent transient ischaemic attack (TIA) or minor stroke with at least one modifiable risk factor. Primary outcome was the composite of subsequent vascular events. Retinal photographs were taken at baseline and categorised into three different fundus groups by a telemedically linked ophthalmologist.722 patients participated in the current study and 109 major vascular events occurred. After multivariable adjustments, we did not find a significant association between fundus categories and risk for subsequent vascular events (HRs for moderate vascular retinopathy and vascular retinopathy with vessel rarefaction in comparison to no vascular retinopathy 1.03 (95
KW  - Humans
KW  - Stroke: diagnosis
KW  - Stroke: epidemiology
KW  - Stroke: complications
KW  - Ischemic Attack, Transient: diagnosis
KW  - Brain Ischemia
KW  - Hypertension: complications
KW  - Retinal Diseases: diagnosis
KW  - Retinal Diseases: epidemiology
KW  - Retinal Diseases: complications
KW  - Diabetes Mellitus
KW  - cerebral infarction (Other)
KW  - ischemic attack, transient (Other)
KW  - stroke (Other)
LB  - PUB:(DE-HGF)16
C2  - pmc:PMC10647888
C6  - pmid:36858463
DO  - DOI:10.1136/svn-2022-001784
UR  - https://pub.dzne.de/record/257690
ER  -